Amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol), enhancement of gene expression and inhibition of lung metastasis by aerosol delivery

We describe the development of an aerosol system for topical gene delivery to the lungs of C57BL/6 mice. This system is based on the combination of the commercial cationic lipid Lipofectin with a novel amphiphilic triblock copolymer, poly( p -dioxanone- co - L -lactide)-block-poly(ethylene glycol) (...

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Veröffentlicht in:	Gene therapy 2007-03, Vol.14 (6), p.476-483
Hauptverfasser:	Bhattarai, S R, Kim, S Y, Jang, K Y, Yi, H K, Lee, Y H, Bhattarai, N, Nam, S-Y, Lee, D Y, Kim, H Y, Hwang, P H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cell Biology Deoxyribonucleic acid DNA Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Therapy - methods Health aspects Health. Pharmaceutical industry Human Genetics Immunohistochemistry Industrial applications and implications. Economical aspects Lipids Lipofectin Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - secondary Lung Neoplasms - therapy Lungs Medical sciences Melanoma Melanoma, Experimental - metabolism Melanoma, Experimental - secondary Melanoma, Experimental - therapy Metastases Metastasis Methods Mice Mice, Inbred C57BL Micelles Nanotechnology original-article Phosphatidylethanolamines Pneumology Polyesters Polyethylene glycol Polyethylene Glycols Polylactic acid Polymers PTEN Phosphohydrolase - analysis PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Rodents Toxicity Transfection - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Tumor suppressor genes Tumors Tumors of the respiratory system and mediastinum
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