Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study
Objective The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine. Background Individuals with migraine can experience generalized (extracephali...
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| Veröffentlicht in: | Headache 2018-01, Vol.58 (1), p.62-77 |
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| creator | You, Dokyoung S. Haney, Rachel Albu, Sergiu Meagher, Mary W. |
| description | Objective
The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine.
Background
Individuals with migraine can experience generalized (extracephalic) hyperalgesia, which can persist even between headache attacks. Elevated levels of plasma and cerebrospinal fluid oxytocin have been observed during migraine attacks, oxytocin levels being positively associated with the intensity of migraine symptoms. However, whether oxytocin plays a role in the mechanisms of generalized pain sensitization and neurogenic inflammation during the interictal period has not been studied yet. Understanding migraineurs' interictal pain phenotype and endogenous oxytocin might help identify individuals who would benefit from intranasal oxytocin treatment.
Methods
Thirty‐two subjects with migraine and 26 healthy controls underwent pain testing. The current study compared capsaicin‐induced pain, central sensitization (areas of secondary mechanical allodynia and hyperalgesia), and neurogenic inflammation (capsaicin‐induced flare) responses on the nondominant volar forearm between migraineurs and healthy controls. Additionally, we studied plasma oxytocin levels and their relationship to migraine symptoms, experimental pain and affect.
Results
The results indicated a significant group effect (P = .019): Migraineurs reported greater capsaicin‐induced pain unpleasantness (M = 1.2, SD = 1.4) on a 0‐10 scale and showed larger areas of flare (LnM = 2.8, SD = 0.4) than healthy controls (M = 0.5, SD = 0.8; LnM = 2.6, SD = 0.4; ps .200), migraineurs. The oxytocin levels were elevated in migraineurs and accounted for 18% of the group difference in capsaicin‐induced pain unpleasantness. Within migraineurs, interictal oxytocin levels were negatively associated with psychological distress (Ps .074). Lastly, the results found no group difference in areas of secondary mechanical allodynia and hyperalgesia (Ps >.298).
Conclusion
The current study revealed that individuals with migraine exhibit enhanced extracephalic capsaicin‐induced pain unpleas |
| doi_str_mv | 10.1111/head.13213 |
| format | Article |
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The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine.
Background
Individuals with migraine can experience generalized (extracephalic) hyperalgesia, which can persist even between headache attacks. Elevated levels of plasma and cerebrospinal fluid oxytocin have been observed during migraine attacks, oxytocin levels being positively associated with the intensity of migraine symptoms. However, whether oxytocin plays a role in the mechanisms of generalized pain sensitization and neurogenic inflammation during the interictal period has not been studied yet. Understanding migraineurs' interictal pain phenotype and endogenous oxytocin might help identify individuals who would benefit from intranasal oxytocin treatment.
Methods
Thirty‐two subjects with migraine and 26 healthy controls underwent pain testing. The current study compared capsaicin‐induced pain, central sensitization (areas of secondary mechanical allodynia and hyperalgesia), and neurogenic inflammation (capsaicin‐induced flare) responses on the nondominant volar forearm between migraineurs and healthy controls. Additionally, we studied plasma oxytocin levels and their relationship to migraine symptoms, experimental pain and affect.
Results
The results indicated a significant group effect (P = .019): Migraineurs reported greater capsaicin‐induced pain unpleasantness (M = 1.2, SD = 1.4) on a 0‐10 scale and showed larger areas of flare (LnM = 2.8, SD = 0.4) than healthy controls (M = 0.5, SD = 0.8; LnM = 2.6, SD = 0.4; ps < .032). In a subgroup analysis, enhanced capsaicin‐induced pain unpleasantness was found in the chronic (P = .007), but not the episodic (Ps > .200), migraineurs. The oxytocin levels were elevated in migraineurs and accounted for 18% of the group difference in capsaicin‐induced pain unpleasantness. Within migraineurs, interictal oxytocin levels were negatively associated with psychological distress (Ps < .030). However, during the interictal period, pain sensitivity in extracephalic regions and plasma oxytocin levels were unrelated to migraine symptom parameters (Ps > .074). Lastly, the results found no group difference in areas of secondary mechanical allodynia and hyperalgesia (Ps >.298).
Conclusion
The current study revealed that individuals with migraine exhibit enhanced extracephalic capsaicin‐induced pain unpleasantness and flare responses during interictal periods. In addition, migraineurs, especially those with chronic migraine, had slightly elevated interictal oxytocin levels compared to controls, which was associated with their affective component of experimental pain. Therefore, treatment targeting affective pain during the interictal period may help to reduce generalized pain in migraine. Furthermore, endogenous increases in oxytocin may be a compensatory mechanism that may help decrease affective distress in migraineurs. The therapeutic effects of intranasal oxytocin may benefit migraineurs by reducing their affective distress.</description><identifier>ISSN: 0017-8748</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1111/head.13213</identifier><identifier>PMID: 29094347</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Capsaicin ; Capsaicin - adverse effects ; capsaicin‐induced pain ; central sensitization ; Cerebrospinal fluid ; Cross-Sectional Studies ; extracephalic pain sensitivity ; Female ; Forearm ; Headache ; Humans ; Hyperalgesia ; Hyperalgesia - physiopathology ; Identification methods ; Inflammation ; interictal pain sensitivity ; Male ; Migraine ; Migraine Disorders - blood ; Migraine Disorders - physiopathology ; Oxytocin ; Oxytocin - blood ; Pain ; Pain - chemically induced ; Pain - metabolism ; Pain - psychology ; Pain Measurement ; Pain perception ; Pain sensitivity ; Pain Threshold - physiology ; Physical Stimulation - adverse effects ; Plasma ; Sensory System Agents - adverse effects ; Statistics, Nonparametric ; Surveys and Questionnaires ; Time Factors ; Young Adult</subject><ispartof>Headache, 2018-01, Vol.58 (1), p.62-77</ispartof><rights>2017 American Headache Society</rights><rights>2017 American Headache Society.</rights><rights>2018 American Headache Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3833-7561a7ce2077744637b639d8d297615e0298c925123f07dd7e069c600222488a3</citedby><cites>FETCH-LOGICAL-c3833-7561a7ce2077744637b639d8d297615e0298c925123f07dd7e069c600222488a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhead.13213$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhead.13213$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29094347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>You, Dokyoung S.</creatorcontrib><creatorcontrib>Haney, Rachel</creatorcontrib><creatorcontrib>Albu, Sergiu</creatorcontrib><creatorcontrib>Meagher, Mary W.</creatorcontrib><title>Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study</title><title>Headache</title><addtitle>Headache</addtitle><description>Objective
The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine.
Background
Individuals with migraine can experience generalized (extracephalic) hyperalgesia, which can persist even between headache attacks. Elevated levels of plasma and cerebrospinal fluid oxytocin have been observed during migraine attacks, oxytocin levels being positively associated with the intensity of migraine symptoms. However, whether oxytocin plays a role in the mechanisms of generalized pain sensitization and neurogenic inflammation during the interictal period has not been studied yet. Understanding migraineurs' interictal pain phenotype and endogenous oxytocin might help identify individuals who would benefit from intranasal oxytocin treatment.
Methods
Thirty‐two subjects with migraine and 26 healthy controls underwent pain testing. The current study compared capsaicin‐induced pain, central sensitization (areas of secondary mechanical allodynia and hyperalgesia), and neurogenic inflammation (capsaicin‐induced flare) responses on the nondominant volar forearm between migraineurs and healthy controls. Additionally, we studied plasma oxytocin levels and their relationship to migraine symptoms, experimental pain and affect.
Results
The results indicated a significant group effect (P = .019): Migraineurs reported greater capsaicin‐induced pain unpleasantness (M = 1.2, SD = 1.4) on a 0‐10 scale and showed larger areas of flare (LnM = 2.8, SD = 0.4) than healthy controls (M = 0.5, SD = 0.8; LnM = 2.6, SD = 0.4; ps < .032). In a subgroup analysis, enhanced capsaicin‐induced pain unpleasantness was found in the chronic (P = .007), but not the episodic (Ps > .200), migraineurs. The oxytocin levels were elevated in migraineurs and accounted for 18% of the group difference in capsaicin‐induced pain unpleasantness. Within migraineurs, interictal oxytocin levels were negatively associated with psychological distress (Ps < .030). However, during the interictal period, pain sensitivity in extracephalic regions and plasma oxytocin levels were unrelated to migraine symptom parameters (Ps > .074). Lastly, the results found no group difference in areas of secondary mechanical allodynia and hyperalgesia (Ps >.298).
Conclusion
The current study revealed that individuals with migraine exhibit enhanced extracephalic capsaicin‐induced pain unpleasantness and flare responses during interictal periods. In addition, migraineurs, especially those with chronic migraine, had slightly elevated interictal oxytocin levels compared to controls, which was associated with their affective component of experimental pain. Therefore, treatment targeting affective pain during the interictal period may help to reduce generalized pain in migraine. Furthermore, endogenous increases in oxytocin may be a compensatory mechanism that may help decrease affective distress in migraineurs. The therapeutic effects of intranasal oxytocin may benefit migraineurs by reducing their affective distress.</description><subject>Adolescent</subject><subject>Capsaicin</subject><subject>Capsaicin - adverse effects</subject><subject>capsaicin‐induced pain</subject><subject>central sensitization</subject><subject>Cerebrospinal fluid</subject><subject>Cross-Sectional Studies</subject><subject>extracephalic pain sensitivity</subject><subject>Female</subject><subject>Forearm</subject><subject>Headache</subject><subject>Humans</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - physiopathology</subject><subject>Identification methods</subject><subject>Inflammation</subject><subject>interictal pain sensitivity</subject><subject>Male</subject><subject>Migraine</subject><subject>Migraine Disorders - blood</subject><subject>Migraine Disorders - physiopathology</subject><subject>Oxytocin</subject><subject>Oxytocin - blood</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - metabolism</subject><subject>Pain - psychology</subject><subject>Pain Measurement</subject><subject>Pain perception</subject><subject>Pain sensitivity</subject><subject>Pain Threshold - physiology</subject><subject>Physical Stimulation - adverse effects</subject><subject>Plasma</subject><subject>Sensory System Agents - adverse effects</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0017-8748</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EokvhwgMgS1wQUsr4T-yY22pZ2kpFRVoQx8iNZ1tXib3ECZA98Qg8I0-CwxYOHBiNNJdvPs3oR8hTBics16sbtO6ECc7EPbJgJVeFVAzukwUA00WlZXVEHqV0CwBSGfWQHHEDRgqpF2R_igF72_o9Ovre-kA3GJIf_N4OPgZqg6Pr4OI1hjgmevltGmKTqdznwfkv3o22TfSTH27oZup2Q-wSjVv6zl_32Yav6ZKu-pjSz-8_NtjMTtvSzTC66TF5sM27-ORuHpOPb9cfVmfFxeXp-Wp5UTSiEqLQpWJWN8hBay2lEvpKCeMqx41WrETgpmoMLxkXW9DOaQRlGgXAOZdVZcUxeXHw7vr4ecQ01J1PDbatDZh_qpkpjeAl8DKjz_9Bb-PY54tnqhLMMJAyUy8PVDM_1uO23vW-s_1UM6jnROo5kfp3Ihl-dqccrzp0f9E_EWSAHYCvvsXpP6r6bL18c5D-AsZflWM</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>You, Dokyoung S.</creator><creator>Haney, Rachel</creator><creator>Albu, Sergiu</creator><creator>Meagher, Mary W.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study</title><author>You, Dokyoung S. ; Haney, Rachel ; Albu, Sergiu ; Meagher, Mary W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3833-7561a7ce2077744637b639d8d297615e0298c925123f07dd7e069c600222488a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Capsaicin</topic><topic>Capsaicin - adverse effects</topic><topic>capsaicin‐induced pain</topic><topic>central sensitization</topic><topic>Cerebrospinal fluid</topic><topic>Cross-Sectional Studies</topic><topic>extracephalic pain sensitivity</topic><topic>Female</topic><topic>Forearm</topic><topic>Headache</topic><topic>Humans</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - physiopathology</topic><topic>Identification methods</topic><topic>Inflammation</topic><topic>interictal pain sensitivity</topic><topic>Male</topic><topic>Migraine</topic><topic>Migraine Disorders - blood</topic><topic>Migraine Disorders - physiopathology</topic><topic>Oxytocin</topic><topic>Oxytocin - blood</topic><topic>Pain</topic><topic>Pain - chemically induced</topic><topic>Pain - metabolism</topic><topic>Pain - psychology</topic><topic>Pain Measurement</topic><topic>Pain perception</topic><topic>Pain sensitivity</topic><topic>Pain Threshold - physiology</topic><topic>Physical Stimulation - adverse effects</topic><topic>Plasma</topic><topic>Sensory System Agents - adverse effects</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>You, Dokyoung S.</creatorcontrib><creatorcontrib>Haney, Rachel</creatorcontrib><creatorcontrib>Albu, Sergiu</creatorcontrib><creatorcontrib>Meagher, Mary W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>You, Dokyoung S.</au><au>Haney, Rachel</au><au>Albu, Sergiu</au><au>Meagher, Mary W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study</atitle><jtitle>Headache</jtitle><addtitle>Headache</addtitle><date>2018-01</date><risdate>2018</risdate><volume>58</volume><issue>1</issue><spage>62</spage><epage>77</epage><pages>62-77</pages><issn>0017-8748</issn><eissn>1526-4610</eissn><abstract>Objective
The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine.
Background
Individuals with migraine can experience generalized (extracephalic) hyperalgesia, which can persist even between headache attacks. Elevated levels of plasma and cerebrospinal fluid oxytocin have been observed during migraine attacks, oxytocin levels being positively associated with the intensity of migraine symptoms. However, whether oxytocin plays a role in the mechanisms of generalized pain sensitization and neurogenic inflammation during the interictal period has not been studied yet. Understanding migraineurs' interictal pain phenotype and endogenous oxytocin might help identify individuals who would benefit from intranasal oxytocin treatment.
Methods
Thirty‐two subjects with migraine and 26 healthy controls underwent pain testing. The current study compared capsaicin‐induced pain, central sensitization (areas of secondary mechanical allodynia and hyperalgesia), and neurogenic inflammation (capsaicin‐induced flare) responses on the nondominant volar forearm between migraineurs and healthy controls. Additionally, we studied plasma oxytocin levels and their relationship to migraine symptoms, experimental pain and affect.
Results
The results indicated a significant group effect (P = .019): Migraineurs reported greater capsaicin‐induced pain unpleasantness (M = 1.2, SD = 1.4) on a 0‐10 scale and showed larger areas of flare (LnM = 2.8, SD = 0.4) than healthy controls (M = 0.5, SD = 0.8; LnM = 2.6, SD = 0.4; ps < .032). In a subgroup analysis, enhanced capsaicin‐induced pain unpleasantness was found in the chronic (P = .007), but not the episodic (Ps > .200), migraineurs. The oxytocin levels were elevated in migraineurs and accounted for 18% of the group difference in capsaicin‐induced pain unpleasantness. Within migraineurs, interictal oxytocin levels were negatively associated with psychological distress (Ps < .030). However, during the interictal period, pain sensitivity in extracephalic regions and plasma oxytocin levels were unrelated to migraine symptom parameters (Ps > .074). Lastly, the results found no group difference in areas of secondary mechanical allodynia and hyperalgesia (Ps >.298).
Conclusion
The current study revealed that individuals with migraine exhibit enhanced extracephalic capsaicin‐induced pain unpleasantness and flare responses during interictal periods. In addition, migraineurs, especially those with chronic migraine, had slightly elevated interictal oxytocin levels compared to controls, which was associated with their affective component of experimental pain. Therefore, treatment targeting affective pain during the interictal period may help to reduce generalized pain in migraine. Furthermore, endogenous increases in oxytocin may be a compensatory mechanism that may help decrease affective distress in migraineurs. The therapeutic effects of intranasal oxytocin may benefit migraineurs by reducing their affective distress.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29094347</pmid><doi>10.1111/head.13213</doi><tpages>16</tpages></addata></record> |
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| subjects | Adolescent Capsaicin Capsaicin - adverse effects capsaicin‐induced pain central sensitization Cerebrospinal fluid Cross-Sectional Studies extracephalic pain sensitivity Female Forearm Headache Humans Hyperalgesia Hyperalgesia - physiopathology Identification methods Inflammation interictal pain sensitivity Male Migraine Migraine Disorders - blood Migraine Disorders - physiopathology Oxytocin Oxytocin - blood Pain Pain - chemically induced Pain - metabolism Pain - psychology Pain Measurement Pain perception Pain sensitivity Pain Threshold - physiology Physical Stimulation - adverse effects Plasma Sensory System Agents - adverse effects Statistics, Nonparametric Surveys and Questionnaires Time Factors Young Adult |
| title | Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study |
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