Trypsin-Treated β-Lactoglobulin Improves Glucose Tolerance in C57BL/6 Mice by Enhancing AMPK Activation and Glucose Uptake in Hepatocytes

It was reported that trypsin-treated β-lactoglobulin (β-LG) had a glucose-lowering effect in the oral glucose tolerance test (OGTT) in mice and a dipeptidyl peptidase-4 (DPP-4) inhibition activity in vitro. However, whether trypsin-treated β-LG improves glucose tolerance by inhibiting DPP-4 in vivo...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/11/01, Vol.40(11), pp.1917-1922
Hauptverfasser:	Tsuda, Yuichi, Iwasawa, Kaori, Yokoyama, Minehiko, Yamaguchi, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Administration, Oral AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Blood Glucose Dipeptidyl Peptidase 4 - metabolism Dipeptidyl-peptidase IV Glucose Glucose - metabolism Glucose tolerance Glucose Tolerance Test glucose uptake Hep G2 Cells Hepatocellular carcinoma Hepatocytes Humans Hyperglycemia Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Insulin Insulin - blood Insulin - metabolism Insulin Secretion Kinases Lactoglobulin Lactoglobulins - chemistry Lactoglobulins - pharmacology Liver Liver cancer Male Mice Mice, Inbred C57BL mouse Oral administration Peptidase Proteolysis Secretion Trypsin Trypsin - metabolism β-Lactoglobulin
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