Does unintentional ingestion of ethylene glycol represent a serious risk?
The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects w...
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| Veröffentlicht in: | Human & experimental toxicology 2007-01, Vol.26 (1), p.59-67 |
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| description | The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum EG levels were included. A variety of clinical and laboratory parameters was collected. The medical records of 86 subjects, who had ingested from one to three swallows of EG, were analysed. The following findings emerged-metabolic acidosis (41%), vomiting (36%), nephrotoxicity (10%), and CNS depression (9%). In 15 children, the time interval between ingestion and hospitalisation was 1 hour or less. Ethanol was given to 12 children (four as first aid), and none developed hypoglycaemia. Of the 71 adults, 93% were treated with ethanol (19 as first aid). No side effects were documented. Seventeen patients received haemodialysis (HD). Two patients recovered without HD; their EG levels were higher than in the HD-treated patients. Unintentional EG ingestion usually involves ingestion of a small amount of EG, and was connected with mild signs of intoxication. Early therapy with ethanol alone appears sufficient in such cases, and represents no risk of adverse effects. |
| doi_str_mv | 10.1177/0960327107073831 |
| format | Article |
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All patients who ingested a known amount of EG and/or subjects with measured serum EG levels were included. A variety of clinical and laboratory parameters was collected. The medical records of 86 subjects, who had ingested from one to three swallows of EG, were analysed. The following findings emerged-metabolic acidosis (41%), vomiting (36%), nephrotoxicity (10%), and CNS depression (9%). In 15 children, the time interval between ingestion and hospitalisation was 1 hour or less. Ethanol was given to 12 children (four as first aid), and none developed hypoglycaemia. Of the 71 adults, 93% were treated with ethanol (19 as first aid). No side effects were documented. Seventeen patients received haemodialysis (HD). Two patients recovered without HD; their EG levels were higher than in the HD-treated patients. Unintentional EG ingestion usually involves ingestion of a small amount of EG, and was connected with mild signs of intoxication. Early therapy with ethanol alone appears sufficient in such cases, and represents no risk of adverse effects.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327107073831</identifier><identifier>PMID: 17334180</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Acidosis ; Adolescent ; Adult ; Adults ; Aged ; Alcoholic beverages ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Child ; Child, Preschool ; Children & youth ; Dose-Response Relationship, Drug ; Ethanol ; Ethylene Glycol - blood ; Ethylene Glycol - poisoning ; Female ; First aid ; Hemodialysis ; Hospitalization ; Hospitals ; Humans ; Hypoglycemia ; Intoxication ; Laboratories ; Male ; Medical records ; Medical sciences ; Metabolism ; Metabolites ; Middle Aged ; Patients ; Poisoning - blood ; Poisoning - epidemiology ; Poisoning - therapy ; Retrospective Studies ; Risk ; Solvents ; Suicides & suicide attempts ; Toxicity ; Toxicology</subject><ispartof>Human & experimental toxicology, 2007-01, Vol.26 (1), p.59-67</ispartof><rights>2007 INIST-CNRS</rights><rights>SAGE Publications © Jan 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-6f19c87409b2be5e6059457e6c21733383b827e11e387e301bf016ae0d454ea93</citedby><cites>FETCH-LOGICAL-c465t-6f19c87409b2be5e6059457e6c21733383b827e11e387e301bf016ae0d454ea93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327107073831$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327107073831$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,778,782,4012,21955,27842,27912,27913,27914,44934,45322</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327107073831?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18509179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17334180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRENOVA, M</creatorcontrib><creatorcontrib>PELCLOVA, D</creatorcontrib><title>Does unintentional ingestion of ethylene glycol represent a serious risk?</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum EG levels were included. A variety of clinical and laboratory parameters was collected. The medical records of 86 subjects, who had ingested from one to three swallows of EG, were analysed. The following findings emerged-metabolic acidosis (41%), vomiting (36%), nephrotoxicity (10%), and CNS depression (9%). In 15 children, the time interval between ingestion and hospitalisation was 1 hour or less. Ethanol was given to 12 children (four as first aid), and none developed hypoglycaemia. Of the 71 adults, 93% were treated with ethanol (19 as first aid). No side effects were documented. Seventeen patients received haemodialysis (HD). Two patients recovered without HD; their EG levels were higher than in the HD-treated patients. Unintentional EG ingestion usually involves ingestion of a small amount of EG, and was connected with mild signs of intoxication. Early therapy with ethanol alone appears sufficient in such cases, and represents no risk of adverse effects.</description><subject>Acidosis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Alcoholic beverages</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. 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Toxic occupational diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol</topic><topic>Ethylene Glycol - blood</topic><topic>Ethylene Glycol - poisoning</topic><topic>Female</topic><topic>First aid</topic><topic>Hemodialysis</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Intoxication</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Poisoning - blood</topic><topic>Poisoning - epidemiology</topic><topic>Poisoning - therapy</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Solvents</topic><topic>Suicides & suicide attempts</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRENOVA, M</creatorcontrib><creatorcontrib>PELCLOVA, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KRENOVA, M</au><au>PELCLOVA, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does unintentional ingestion of ethylene glycol represent a serious risk?</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>26</volume><issue>1</issue><spage>59</spage><epage>67</epage><pages>59-67</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum EG levels were included. A variety of clinical and laboratory parameters was collected. The medical records of 86 subjects, who had ingested from one to three swallows of EG, were analysed. The following findings emerged-metabolic acidosis (41%), vomiting (36%), nephrotoxicity (10%), and CNS depression (9%). In 15 children, the time interval between ingestion and hospitalisation was 1 hour or less. Ethanol was given to 12 children (four as first aid), and none developed hypoglycaemia. Of the 71 adults, 93% were treated with ethanol (19 as first aid). No side effects were documented. Seventeen patients received haemodialysis (HD). Two patients recovered without HD; their EG levels were higher than in the HD-treated patients. Unintentional EG ingestion usually involves ingestion of a small amount of EG, and was connected with mild signs of intoxication. Early therapy with ethanol alone appears sufficient in such cases, and represents no risk of adverse effects.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>17334180</pmid><doi>10.1177/0960327107073831</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Acidosis Adolescent Adult Adults Aged Alcoholic beverages Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Child Child, Preschool Children & youth Dose-Response Relationship, Drug Ethanol Ethylene Glycol - blood Ethylene Glycol - poisoning Female First aid Hemodialysis Hospitalization Hospitals Humans Hypoglycemia Intoxication Laboratories Male Medical records Medical sciences Metabolism Metabolites Middle Aged Patients Poisoning - blood Poisoning - epidemiology Poisoning - therapy Retrospective Studies Risk Solvents Suicides & suicide attempts Toxicity Toxicology |
| title | Does unintentional ingestion of ethylene glycol represent a serious risk? |
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