Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct
The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis-[PtCl 2(NH 3) 2], [PtCl 2(SMC)] and [PtCl 2(DMSO) 2] (where SMC is S-methyl- l-cysteine and...
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| Veröffentlicht in: | Toxicology in vitro 2008-12, Vol.22 (8), p.1878-1882 |
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| creator | Bugarcic, Z D Petrovic, B Bugarcic, Z M Jankovic, S M Jankovic, S V Lukic, G Novakovic, M Kostovic, V Popovic, S Djurdjevic, P Baskic, D Arsenijevic, N |
| description | The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin,
cis-[PtCl
2(NH
3)
2], [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] (where SMC is S-methyl-
l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC). However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl
2(SMC)] and [PtCl
2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined.
Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC
50
=
1.14
±
0.03
×
10
−6
M/l,
r
=
0.714,
p
<
0.05) while [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] did not affect spontaneous contractions of isolated fallopian tube ampulla. |
| doi_str_mv | 10.1016/j.tiv.2008.09.011 |
| format | Article |
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cis-[PtCl
2(NH
3)
2], [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] (where SMC is S-methyl-
l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC). However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl
2(SMC)] and [PtCl
2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined.
Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC
50
=
1.14
±
0.03
×
10
−6
M/l,
r
=
0.714,
p
<
0.05) while [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] did not affect spontaneous contractions of isolated fallopian tube ampulla.</description><identifier>ISSN: 0887-2333</identifier><identifier>EISSN: 1879-3177</identifier><identifier>DOI: 10.1016/j.tiv.2008.09.011</identifier><identifier>PMID: 18848615</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - toxicity ; Apoptosis - drug effects ; Cisplatin - administration & dosage ; Cisplatin - chemistry ; Cisplatin - toxicity ; Cysteine - analogs & derivatives ; Cysteine - chemistry ; Cytotoxicity ; Dimethyl Sulfoxide - chemistry ; Dose-Response Relationship, Drug ; Fallopian Tubes - drug effects ; Fallopian Tubes - metabolism ; Female ; Human fallopian tubes ; Humans ; In Vitro Techniques ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Middle Aged ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - metabolism ; Platinum(II)</subject><ispartof>Toxicology in vitro, 2008-12, Vol.22 (8), p.1878-1882</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-a5dac752c60f56c8db844eba717f271bb681e35ed65ad64b3728601283c4f45e3</citedby><cites>FETCH-LOGICAL-c382t-a5dac752c60f56c8db844eba717f271bb681e35ed65ad64b3728601283c4f45e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0887233308002300$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18848615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bugarcic, Z D</creatorcontrib><creatorcontrib>Petrovic, B</creatorcontrib><creatorcontrib>Bugarcic, Z M</creatorcontrib><creatorcontrib>Jankovic, S M</creatorcontrib><creatorcontrib>Jankovic, S V</creatorcontrib><creatorcontrib>Lukic, G</creatorcontrib><creatorcontrib>Novakovic, M</creatorcontrib><creatorcontrib>Kostovic, V</creatorcontrib><creatorcontrib>Popovic, S</creatorcontrib><creatorcontrib>Djurdjevic, P</creatorcontrib><creatorcontrib>Baskic, D</creatorcontrib><creatorcontrib>Arsenijevic, N</creatorcontrib><title>Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct</title><title>Toxicology in vitro</title><addtitle>Toxicol In Vitro</addtitle><description>The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin,
cis-[PtCl
2(NH
3)
2], [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] (where SMC is S-methyl-
l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC). However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl
2(SMC)] and [PtCl
2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined.
Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC
50
=
1.14
±
0.03
×
10
−6
M/l,
r
=
0.714,
p
<
0.05) while [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] did not affect spontaneous contractions of isolated fallopian tube ampulla.</description><subject>Adult</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Apoptosis - drug effects</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - chemistry</subject><subject>Cisplatin - toxicity</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - chemistry</subject><subject>Cytotoxicity</subject><subject>Dimethyl Sulfoxide - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fallopian Tubes - drug effects</subject><subject>Fallopian Tubes - metabolism</subject><subject>Female</subject><subject>Human fallopian tubes</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Middle Aged</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - metabolism</subject><subject>Platinum(II)</subject><issn>0887-2333</issn><issn>1879-3177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1r2zAYh8VYadKPP2CXodPoDvYky_oIPZWSbYFCe1jPQpZeEwXb8iw5NP99FRLorSddnufHqwehb5SUlFDxa1cmvy8rQlRJViWh9AtaUiVXBaNSfkVLopQsKsbYAl3FuCOEcFWRS7SgStVKUL5EZt22YFPEocXWx7EzyQ_YDA6HtIUJv6S7zeYntqEfO3iDzA04jmFIZoAwR9yH5DufDkffx5B1cHg792bAYe_dbNMNumhNF-H2_F6j19_rf49_i6fnP5vHh6fCMlWlwnBnrOSVFaTlwirXqLqGxkgq20rSphGKAuPgBDdO1A2TlRKEVorZuq05sGv047Q7TuH_DDHp3kcLXXe6VNMVz2mIyCA9gXYKMU7Q6nHyvZkOmhJ97Kp3OnfVx66arHTump3v5_G56cF9GOeQGbg_AZC_uPcw6Wg9DBacn3Jf7YL_ZP4dT5KJnA</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Bugarcic, Z D</creator><creator>Petrovic, B</creator><creator>Bugarcic, Z M</creator><creator>Jankovic, S M</creator><creator>Jankovic, S V</creator><creator>Lukic, G</creator><creator>Novakovic, M</creator><creator>Kostovic, V</creator><creator>Popovic, S</creator><creator>Djurdjevic, P</creator><creator>Baskic, D</creator><creator>Arsenijevic, N</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20081201</creationdate><title>Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct</title><author>Bugarcic, Z D ; Petrovic, B ; Bugarcic, Z M ; Jankovic, S M ; Jankovic, S V ; Lukic, G ; Novakovic, M ; Kostovic, V ; Popovic, S ; Djurdjevic, P ; Baskic, D ; Arsenijevic, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-a5dac752c60f56c8db844eba717f271bb681e35ed65ad64b3728601283c4f45e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Apoptosis - drug effects</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - chemistry</topic><topic>Cisplatin - toxicity</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - chemistry</topic><topic>Cytotoxicity</topic><topic>Dimethyl Sulfoxide - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fallopian Tubes - drug effects</topic><topic>Fallopian Tubes - metabolism</topic><topic>Female</topic><topic>Human fallopian tubes</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Middle Aged</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - metabolism</topic><topic>Platinum(II)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bugarcic, Z D</creatorcontrib><creatorcontrib>Petrovic, B</creatorcontrib><creatorcontrib>Bugarcic, Z M</creatorcontrib><creatorcontrib>Jankovic, S M</creatorcontrib><creatorcontrib>Jankovic, S V</creatorcontrib><creatorcontrib>Lukic, G</creatorcontrib><creatorcontrib>Novakovic, M</creatorcontrib><creatorcontrib>Kostovic, V</creatorcontrib><creatorcontrib>Popovic, S</creatorcontrib><creatorcontrib>Djurdjevic, P</creatorcontrib><creatorcontrib>Baskic, D</creatorcontrib><creatorcontrib>Arsenijevic, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology in vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bugarcic, Z D</au><au>Petrovic, B</au><au>Bugarcic, Z M</au><au>Jankovic, S M</au><au>Jankovic, S V</au><au>Lukic, G</au><au>Novakovic, M</au><au>Kostovic, V</au><au>Popovic, S</au><au>Djurdjevic, P</au><au>Baskic, D</au><au>Arsenijevic, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct</atitle><jtitle>Toxicology in vitro</jtitle><addtitle>Toxicol In Vitro</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>22</volume><issue>8</issue><spage>1878</spage><epage>1882</epage><pages>1878-1882</pages><issn>0887-2333</issn><eissn>1879-3177</eissn><abstract>The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin,
cis-[PtCl
2(NH
3)
2], [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] (where SMC is S-methyl-
l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC). However, peripheral blood mononuclear cells were substantially less sensitive to [PtCl
2(SMC)] and [PtCl
2(DMSO)], and these compounds showed no toxic effect on PBMC in all concentrations examined.
Cisplatin showed concentration-dependent inhibition of spontaneous contractions of the isolated ampulla. (EC
50
=
1.14
±
0.03
×
10
−6
M/l,
r
=
0.714,
p
<
0.05) while [PtCl
2(SMC)] and [PtCl
2(DMSO)
2] did not affect spontaneous contractions of isolated fallopian tube ampulla.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18848615</pmid><doi>10.1016/j.tiv.2008.09.011</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-2333 |
| ispartof | Toxicology in vitro, 2008-12, Vol.22 (8), p.1878-1882 |
| issn | 0887-2333 1879-3177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19587906 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Apoptosis - drug effects Cisplatin - administration & dosage Cisplatin - chemistry Cisplatin - toxicity Cysteine - analogs & derivatives Cysteine - chemistry Cytotoxicity Dimethyl Sulfoxide - chemistry Dose-Response Relationship, Drug Fallopian Tubes - drug effects Fallopian Tubes - metabolism Female Human fallopian tubes Humans In Vitro Techniques Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Middle Aged Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Platinum(II) |
| title | Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct |
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