p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca super(2+) homeostasis

p66Shc, a redox enzyme that enhances reactive oxygen species (ROS) production by mitochondria, promotes T cell apoptosis. We have addressed the mechanisms regulating p66Shc-dependent apoptosis in T cells exposed to supraphysiological increases in [Ca super(2+)] sub(c). p66Shc expression resulted in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell death and differentiation 2007-02, Vol.14 (2), p.338-347
Hauptverfasser:	Pellegrini, M, Finetti, F, Petronilli, V, Ulivieri, C, Giusti, F, Lupetti, P, Giorgio, M, Pelicci, P G, Bernardi, P, Baldari, C T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!