Transgender Man Being Evaluated for a Kidney Transplant
Urine protein excretion was 3 g/day. Because transplant candidates require a GFR
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2017-11, Vol.63 (11), p.1680-1683 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Whitley, Cameron T Greene, Dina N |
| description | Urine protein excretion was 3 g/day. Because transplant candidates require a GFR |
| doi_str_mv | 10.1373/clinchem.2016.268839 |
| format | Article |
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Because transplant candidates require a GFR <20 mL/ min/1.73m2 (1) and because the patient's malecalculated eGFR was above the cutoff, he was not listed. [...]because creatinine-based eGFR equations are dependent on sex/gender congruence and racial demographics, gender nonconformity and mixed ancestry challenge their applicability. There is no literature indicating that maintaining a testosterone concentration within male-specific normal ranges affects kidney function. [...]studies on cisgender men show that decreasing testosterone concentration portends worse CKD outcomes (6, 7). What other laboratory results may be difficult to interpret in transgender patients? POINTS TO REMEMBER * A transgender individual is a person whose biological sex does not match their gender identity. * Kidney health is evaluated using laboratory measurements to estimate function (GFR) and damage (proteinuria). * Interpreting sex-specific reference limits in transgender individuals is complicated, particularly for eGFR where muscle mass is an integral component. * When assessing renal function in transgender patients, consideration should be given to sex-independent methods such as iothalamate clearance. * Address correspondence to this author at:</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2016.268839</identifier><identifier>PMID: 29089320</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Creatinine ; Damage assessment ; Demographics ; Diet ; Endocrine therapy ; Evaluation ; Female ; Gender ; Gender aspects ; Gender identity ; Glomerular Filtration Rate ; Humans ; Kidney diseases ; Kidney Transplantation ; Kidney transplants ; Kidneys ; Laboratories ; Male ; Men ; Mens health ; Muscles ; Patients ; Proteins ; Proteinuria ; Renal function ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - surgery ; Sex ; Testosterone ; Transgender Persons ; Transplants & implants ; Urine ; Womens health</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2017-11, Vol.63 (11), p.1680-1683</ispartof><rights>Copyright American Association for Clinical Chemistry Nov 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-f7a19636fb1761b38a1d56322ab328bc40fe02afa93bde60b9ed109ca7ef3eaf3</citedby><cites>FETCH-LOGICAL-c335t-f7a19636fb1761b38a1d56322ab328bc40fe02afa93bde60b9ed109ca7ef3eaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29089320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitley, Cameron T</creatorcontrib><creatorcontrib>Greene, Dina N</creatorcontrib><title>Transgender Man Being Evaluated for a Kidney Transplant</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>Urine protein excretion was 3 g/day. Because transplant candidates require a GFR <20 mL/ min/1.73m2 (1) and because the patient's malecalculated eGFR was above the cutoff, he was not listed. [...]because creatinine-based eGFR equations are dependent on sex/gender congruence and racial demographics, gender nonconformity and mixed ancestry challenge their applicability. There is no literature indicating that maintaining a testosterone concentration within male-specific normal ranges affects kidney function. [...]studies on cisgender men show that decreasing testosterone concentration portends worse CKD outcomes (6, 7). What other laboratory results may be difficult to interpret in transgender patients? POINTS TO REMEMBER * A transgender individual is a person whose biological sex does not match their gender identity. * Kidney health is evaluated using laboratory measurements to estimate function (GFR) and damage (proteinuria). * Interpreting sex-specific reference limits in transgender individuals is complicated, particularly for eGFR where muscle mass is an integral component. * When assessing renal function in transgender patients, consideration should be given to sex-independent methods such as iothalamate clearance. * Address correspondence to this author at:</description><subject>Adult</subject><subject>Creatinine</subject><subject>Damage assessment</subject><subject>Demographics</subject><subject>Diet</subject><subject>Endocrine therapy</subject><subject>Evaluation</subject><subject>Female</subject><subject>Gender</subject><subject>Gender aspects</subject><subject>Gender identity</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Male</subject><subject>Men</subject><subject>Mens health</subject><subject>Muscles</subject><subject>Patients</subject><subject>Proteins</subject><subject>Proteinuria</subject><subject>Renal function</subject><subject>Renal Insufficiency, Chronic - 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diagnosis</topic><topic>Renal Insufficiency, Chronic - surgery</topic><topic>Sex</topic><topic>Testosterone</topic><topic>Transgender Persons</topic><topic>Transplants & implants</topic><topic>Urine</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitley, Cameron T</creatorcontrib><creatorcontrib>Greene, Dina N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitley, Cameron T</au><au>Greene, Dina N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transgender Man Being Evaluated for a Kidney Transplant</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2017-11</date><risdate>2017</risdate><volume>63</volume><issue>11</issue><spage>1680</spage><epage>1683</epage><pages>1680-1683</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><abstract>Urine protein excretion was 3 g/day. Because transplant candidates require a GFR <20 mL/ min/1.73m2 (1) and because the patient's malecalculated eGFR was above the cutoff, he was not listed. [...]because creatinine-based eGFR equations are dependent on sex/gender congruence and racial demographics, gender nonconformity and mixed ancestry challenge their applicability. There is no literature indicating that maintaining a testosterone concentration within male-specific normal ranges affects kidney function. [...]studies on cisgender men show that decreasing testosterone concentration portends worse CKD outcomes (6, 7). What other laboratory results may be difficult to interpret in transgender patients? POINTS TO REMEMBER * A transgender individual is a person whose biological sex does not match their gender identity. * Kidney health is evaluated using laboratory measurements to estimate function (GFR) and damage (proteinuria). * Interpreting sex-specific reference limits in transgender individuals is complicated, particularly for eGFR where muscle mass is an integral component. * When assessing renal function in transgender patients, consideration should be given to sex-independent methods such as iothalamate clearance. * Address correspondence to this author at:</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29089320</pmid><doi>10.1373/clinchem.2016.268839</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9147 |
| ispartof | Clinical chemistry (Baltimore, Md.), 2017-11, Vol.63 (11), p.1680-1683 |
| issn | 0009-9147 1530-8561 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adult Creatinine Damage assessment Demographics Diet Endocrine therapy Evaluation Female Gender Gender aspects Gender identity Glomerular Filtration Rate Humans Kidney diseases Kidney Transplantation Kidney transplants Kidneys Laboratories Male Men Mens health Muscles Patients Proteins Proteinuria Renal function Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - surgery Sex Testosterone Transgender Persons Transplants & implants Urine Womens health |
| title | Transgender Man Being Evaluated for a Kidney Transplant |
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