Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study
Purpose Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). Methods Thirty‐two patients with ON due to MS within 3 months of onset of symptoms were enro...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2018-05, Vol.96 (3), p.e309-e314 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Svrčinová, Tereza Mareš, Jan Chrapek, Oldřich Šínová, Irena Rybariková, Martina Otruba, Pavel Kaňovský, Petr Šín, Martin |
| description | Purpose
Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS).
Methods
Thirty‐two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing‐remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint®, Minneapolis, MN, USA).
Results
Arterio‐venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) [34.2 ± 4.7 versus 31.3 ± 4.6, p = 0.044 (mean ± standard deviation)]. No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p |
| doi_str_mv | 10.1111/aos.13571 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1958541826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1958541826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3881-d3f438ed5da2b6b6dbdd580f346499c658bc98d4d761db1bcb63351defdd5bec3</originalsourceid><addsrcrecordid>eNp10U9PHCEYBnDS1FTd9tAv0JD0ood1YRkY5mg2_ktMPKhJbwSGd1zMLEyBqZ2b36HfsJ9EdNVDk3J5Ofx4kpcHoa-UHNFyFjqkI8p4TT-gPVpzPme1kB_f7_zHLtpP6Z4QQYWoPqHdZUMaIiu2h4bVWvs7SNh5HH5Pd-Bx0nmMOrvgsfYW5zXgCNl53WMP8RfgzpkIuNcTxOdnQ7Hgc8IPLq9xGLJrCxyjyy7hv49_sMaD60PGKY92-ox2Ot0n-PI6Z-j29ORmdT6_vDq7WB1fzlsmJZ1b1lVMguVWL40wwhpruSQdq0TVNK3g0rSNtJWtBbWGmtYIxji10BVnoGUzdLDNHWL4OULKauNSC32vPYQxKdpwySsql6LQ7__Q-zDGsm9SS8JIXaCkRR1uVRtDShE6NUS30XFSlKjnGlSpQb3UUOy318TRbMC-y7d_L2CxBQ-uh-n_Ser46nob-QTl3JP7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2030758581</pqid></control><display><type>article</type><title>Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Svrčinová, Tereza ; Mareš, Jan ; Chrapek, Oldřich ; Šínová, Irena ; Rybariková, Martina ; Otruba, Pavel ; Kaňovský, Petr ; Šín, Martin</creator><creatorcontrib>Svrčinová, Tereza ; Mareš, Jan ; Chrapek, Oldřich ; Šínová, Irena ; Rybariková, Martina ; Otruba, Pavel ; Kaňovský, Petr ; Šín, Martin</creatorcontrib><description>Purpose
Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS).
Methods
Thirty‐two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing‐remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint®, Minneapolis, MN, USA).
Results
Arterio‐venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) [34.2 ± 4.7 versus 31.3 ± 4.6, p = 0.044 (mean ± standard deviation)]. No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p < 0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS.
Conclusion
The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.13571</identifier><identifier>PMID: 29090843</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Eye ; Females ; Inflammation ; Males ; Multiple sclerosis ; Nerve conduction ; Neuritis ; Optic nerve ; Optic neuritis ; Optical Coherence Tomography ; Optics ; Oximetry ; Oxygen ; Oxygen content ; Oxygen saturation ; Retina ; Saturation ; Statistical analysis ; Visual evoked potentials</subject><ispartof>Acta ophthalmologica (Oxford, England), 2018-05, Vol.96 (3), p.e309-e314</ispartof><rights>2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-d3f438ed5da2b6b6dbdd580f346499c658bc98d4d761db1bcb63351defdd5bec3</citedby><cites>FETCH-LOGICAL-c3881-d3f438ed5da2b6b6dbdd580f346499c658bc98d4d761db1bcb63351defdd5bec3</cites><orcidid>0000-0002-5073-9482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.13571$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.13571$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29090843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Svrčinová, Tereza</creatorcontrib><creatorcontrib>Mareš, Jan</creatorcontrib><creatorcontrib>Chrapek, Oldřich</creatorcontrib><creatorcontrib>Šínová, Irena</creatorcontrib><creatorcontrib>Rybariková, Martina</creatorcontrib><creatorcontrib>Otruba, Pavel</creatorcontrib><creatorcontrib>Kaňovský, Petr</creatorcontrib><creatorcontrib>Šín, Martin</creatorcontrib><title>Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS).
Methods
Thirty‐two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing‐remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint®, Minneapolis, MN, USA).
Results
Arterio‐venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) [34.2 ± 4.7 versus 31.3 ± 4.6, p = 0.044 (mean ± standard deviation)]. No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p < 0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS.
Conclusion
The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.</description><subject>Eye</subject><subject>Females</subject><subject>Inflammation</subject><subject>Males</subject><subject>Multiple sclerosis</subject><subject>Nerve conduction</subject><subject>Neuritis</subject><subject>Optic nerve</subject><subject>Optic neuritis</subject><subject>Optical Coherence Tomography</subject><subject>Optics</subject><subject>Oximetry</subject><subject>Oxygen</subject><subject>Oxygen content</subject><subject>Oxygen saturation</subject><subject>Retina</subject><subject>Saturation</subject><subject>Statistical analysis</subject><subject>Visual evoked potentials</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10U9PHCEYBnDS1FTd9tAv0JD0ood1YRkY5mg2_ktMPKhJbwSGd1zMLEyBqZ2b36HfsJ9EdNVDk3J5Ofx4kpcHoa-UHNFyFjqkI8p4TT-gPVpzPme1kB_f7_zHLtpP6Z4QQYWoPqHdZUMaIiu2h4bVWvs7SNh5HH5Pd-Bx0nmMOrvgsfYW5zXgCNl53WMP8RfgzpkIuNcTxOdnQ7Hgc8IPLq9xGLJrCxyjyy7hv49_sMaD60PGKY92-ox2Ot0n-PI6Z-j29ORmdT6_vDq7WB1fzlsmJZ1b1lVMguVWL40wwhpruSQdq0TVNK3g0rSNtJWtBbWGmtYIxji10BVnoGUzdLDNHWL4OULKauNSC32vPYQxKdpwySsql6LQ7__Q-zDGsm9SS8JIXaCkRR1uVRtDShE6NUS30XFSlKjnGlSpQb3UUOy318TRbMC-y7d_L2CxBQ-uh-n_Ser46nob-QTl3JP7</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Svrčinová, Tereza</creator><creator>Mareš, Jan</creator><creator>Chrapek, Oldřich</creator><creator>Šínová, Irena</creator><creator>Rybariková, Martina</creator><creator>Otruba, Pavel</creator><creator>Kaňovský, Petr</creator><creator>Šín, Martin</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5073-9482</orcidid></search><sort><creationdate>201805</creationdate><title>Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study</title><author>Svrčinová, Tereza ; Mareš, Jan ; Chrapek, Oldřich ; Šínová, Irena ; Rybariková, Martina ; Otruba, Pavel ; Kaňovský, Petr ; Šín, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-d3f438ed5da2b6b6dbdd580f346499c658bc98d4d761db1bcb63351defdd5bec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Eye</topic><topic>Females</topic><topic>Inflammation</topic><topic>Males</topic><topic>Multiple sclerosis</topic><topic>Nerve conduction</topic><topic>Neuritis</topic><topic>Optic nerve</topic><topic>Optic neuritis</topic><topic>Optical Coherence Tomography</topic><topic>Optics</topic><topic>Oximetry</topic><topic>Oxygen</topic><topic>Oxygen content</topic><topic>Oxygen saturation</topic><topic>Retina</topic><topic>Saturation</topic><topic>Statistical analysis</topic><topic>Visual evoked potentials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svrčinová, Tereza</creatorcontrib><creatorcontrib>Mareš, Jan</creatorcontrib><creatorcontrib>Chrapek, Oldřich</creatorcontrib><creatorcontrib>Šínová, Irena</creatorcontrib><creatorcontrib>Rybariková, Martina</creatorcontrib><creatorcontrib>Otruba, Pavel</creatorcontrib><creatorcontrib>Kaňovský, Petr</creatorcontrib><creatorcontrib>Šín, Martin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svrčinová, Tereza</au><au>Mareš, Jan</au><au>Chrapek, Oldřich</au><au>Šínová, Irena</au><au>Rybariková, Martina</au><au>Otruba, Pavel</au><au>Kaňovský, Petr</au><au>Šín, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2018-05</date><risdate>2018</risdate><volume>96</volume><issue>3</issue><spage>e309</spage><epage>e314</epage><pages>e309-e314</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS).
Methods
Thirty‐two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing‐remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint®, Minneapolis, MN, USA).
Results
Arterio‐venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) [34.2 ± 4.7 versus 31.3 ± 4.6, p = 0.044 (mean ± standard deviation)]. No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p < 0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS.
Conclusion
The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29090843</pmid><doi>10.1111/aos.13571</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5073-9482</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2018-05, Vol.96 (3), p.e309-e314 |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete |
| subjects | Eye Females Inflammation Males Multiple sclerosis Nerve conduction Neuritis Optic nerve Optic neuritis Optical Coherence Tomography Optics Oximetry Oxygen Oxygen content Oxygen saturation Retina Saturation Statistical analysis Visual evoked potentials |
| title | Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis – a pilot study |
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