Adenovirus‐mediated human aquaporin‐1 expression in hepatocytes improves lipopolysaccharide‐induced cholestasis

Lipopolysaccharides (LPS) are known to cause cholestasis in sepsis. There is evidence that a defective expression of canalicular aquaporin water channels contributes to bile secretory failure in LPS‐induced cholestasis. Thus, we studied whether the hepatic adenovirus‐mediated transfer of human aquap...

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