Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy
Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were perfo...
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| Veröffentlicht in: | Journal of integrative neuroscience 2018, Vol.17 (3-4), p.331-346 |
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| container_issue | 3-4 |
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| container_title | Journal of integrative neuroscience |
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| creator | Teslenko, Elena L Damyanovich, Elena V Damjanović, Ilija Gačić, Zoran Baziyan, Boris K |
| description | Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were performed in two independent experimental procedures - for saccades separately and when they were in coordination with the motion of head and hand. In both cases statistically significant differences in latent periods and durations of saccadic eye movements were noticed in HIE patients in comparison with healthy subjects of the same age group (p |
| doi_str_mv | 10.3233/JIN-170055 |
| format | Article |
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We found HIE induced changes in the parameters of autosaccades as well, expressed through the instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another and disturbance of gaze stabilization (as jerking of the eyeballs during the saccadic period).</description><identifier>ISSN: 0219-6352</identifier><identifier>EISSN: 1757-448X</identifier><identifier>DOI: 10.3233/JIN-170055</identifier><identifier>PMID: 29081419</identifier><language>eng</language><publisher>England: IOS Press BV</publisher><subject>Aged ; Encephalopathy ; Eye movements ; Hand - physiopathology ; Head - physiopathology ; Head Movements - physiology ; Humans ; Hypoxia ; Hypoxia-Ischemia, Brain - physiopathology ; Ischemia ; Middle Aged ; Motor Skills - physiology ; Patients ; Physical activity ; Saccades - physiology ; Saccadic eye movements ; Stability ; Statistical analysis</subject><ispartof>Journal of integrative neuroscience, 2018, Vol.17 (3-4), p.331-346</ispartof><rights>Copyright IOS Press BV 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2255-16cb3f391ade49370d7772ad6e89c1b61906cfeb7adb83acb194de909db119d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29081419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teslenko, Elena L</creatorcontrib><creatorcontrib>Damyanovich, Elena V</creatorcontrib><creatorcontrib>Damjanović, Ilija</creatorcontrib><creatorcontrib>Gačić, Zoran</creatorcontrib><creatorcontrib>Baziyan, Boris K</creatorcontrib><title>Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy</title><title>Journal of integrative neuroscience</title><addtitle>J Integr Neurosci</addtitle><description>Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were performed in two independent experimental procedures - for saccades separately and when they were in coordination with the motion of head and hand. In both cases statistically significant differences in latent periods and durations of saccadic eye movements were noticed in HIE patients in comparison with healthy subjects of the same age group (p<0.05). Jerking and deviation of eyes after fixing the gaze on a target were often present in HIE participants. In some cases saccades of patients were asymmetrical among themselves. We found HIE induced changes in the parameters of autosaccades as well, expressed through the instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another and disturbance of gaze stabilization (as jerking of the eyeballs during the saccadic period).</description><subject>Aged</subject><subject>Encephalopathy</subject><subject>Eye movements</subject><subject>Hand - physiopathology</subject><subject>Head - physiopathology</subject><subject>Head Movements - physiology</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Ischemia, Brain - physiopathology</subject><subject>Ischemia</subject><subject>Middle Aged</subject><subject>Motor Skills - physiology</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Saccades - physiology</subject><subject>Saccadic eye movements</subject><subject>Stability</subject><subject>Statistical analysis</subject><issn>0219-6352</issn><issn>1757-448X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLxDAUBeAgijM-Nv4AKbgRoZqbNE2zlGHUkUEXKrgLaZLSDH3ZtGj_vZEZXbi6XPg4HA5CZ4CvKaH05nH1FAPHmLE9NAfOeJwk2fs-mmMCIk4pIzN05P0Gh58KfIhmROAMEhBztHxRWivjdGQmX4yNHlzbRK6JOjU42ww--nRDGZVT1345HTuvS1sHbRttu1JVbXDldIIOClV5e7q7x-jtbvm6eIjXz_erxe061oQwFkOqc1pQAcrYRFCODeecKJPaTGjIUxA41YXNuTJ5RpXOQSTGCixMDiAMp8focpvb9e3HaP0g69DIVpVqbDt6CYKFRMiICPTiH920Y9-EdpIAJgRTwkhQV1ul-9b73hay612t-kkClj_jyjCu3I4b8Pkucsxra_7o75r0G4szdAE</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Teslenko, Elena L</creator><creator>Damyanovich, Elena V</creator><creator>Damjanović, Ilija</creator><creator>Gačić, Zoran</creator><creator>Baziyan, Boris K</creator><general>IOS Press BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy</title><author>Teslenko, Elena L ; Damyanovich, Elena V ; Damjanović, Ilija ; Gačić, Zoran ; Baziyan, Boris K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2255-16cb3f391ade49370d7772ad6e89c1b61906cfeb7adb83acb194de909db119d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Encephalopathy</topic><topic>Eye movements</topic><topic>Hand - physiopathology</topic><topic>Head - physiopathology</topic><topic>Head Movements - physiology</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia-Ischemia, Brain - physiopathology</topic><topic>Ischemia</topic><topic>Middle Aged</topic><topic>Motor Skills - physiology</topic><topic>Patients</topic><topic>Physical activity</topic><topic>Saccades - physiology</topic><topic>Saccadic eye movements</topic><topic>Stability</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teslenko, Elena L</creatorcontrib><creatorcontrib>Damyanovich, Elena V</creatorcontrib><creatorcontrib>Damjanović, Ilija</creatorcontrib><creatorcontrib>Gačić, Zoran</creatorcontrib><creatorcontrib>Baziyan, Boris K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of integrative neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teslenko, Elena L</au><au>Damyanovich, Elena V</au><au>Damjanović, Ilija</au><au>Gačić, Zoran</au><au>Baziyan, Boris K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy</atitle><jtitle>Journal of integrative neuroscience</jtitle><addtitle>J Integr Neurosci</addtitle><date>2018</date><risdate>2018</risdate><volume>17</volume><issue>3-4</issue><spage>331</spage><epage>346</epage><pages>331-346</pages><issn>0219-6352</issn><eissn>1757-448X</eissn><abstract>Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy (HIE) was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying the subject's physical activity. Recordings were performed in two independent experimental procedures - for saccades separately and when they were in coordination with the motion of head and hand. In both cases statistically significant differences in latent periods and durations of saccadic eye movements were noticed in HIE patients in comparison with healthy subjects of the same age group (p<0.05). Jerking and deviation of eyes after fixing the gaze on a target were often present in HIE participants. In some cases saccades of patients were asymmetrical among themselves. We found HIE induced changes in the parameters of autosaccades as well, expressed through the instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another and disturbance of gaze stabilization (as jerking of the eyeballs during the saccadic period).</abstract><cop>England</cop><pub>IOS Press BV</pub><pmid>29081419</pmid><doi>10.3233/JIN-170055</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Aged Encephalopathy Eye movements Hand - physiopathology Head - physiopathology Head Movements - physiology Humans Hypoxia Hypoxia-Ischemia, Brain - physiopathology Ischemia Middle Aged Motor Skills - physiology Patients Physical activity Saccades - physiology Saccadic eye movements Stability Statistical analysis |
| title | Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy |
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