Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment
Background and purpose Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients. Methods Seventy‐...
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| Veröffentlicht in: | European journal of neurology 2018-02, Vol.25 (2), p.326-333 |
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| creator | Lee, J. Seo, S. W. Yang, J.‐J. Jang, Y. K. Lee, J. S. Kim, Y. J. Chin, J. Lee, J. M. Kim, S. T. Lee, K.‐H. Lee, J. H. Kim, J. S. Kim, S. Yoo, H. Lee, A. Y. Na, D. L. Kim, H. J. |
| description | Background and purpose
Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.
Methods
Seventy‐two svMCI patients were divided into early stage (ES‐svMCI, n = 39) and late stage (LS‐svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.
Results
There was no difference in the rate of increase in PiB uptake or lacune number between the ES‐svMCI and LS‐svMCI. However, LS‐svMCI showed more rapid cortical thinning and cognitive decline than did the ES‐svMCI.
Conclusions
We suggest that, whilst the rate of change in pathological burden did not differ between ES‐svMCI and LS‐svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS‐svMCI. |
| doi_str_mv | 10.1111/ene.13500 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1957768070</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1989563614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3530-a1cb2506f400a8f79de78d3c5ec0453cc30505c4a71816f9ad3ae338058b1b8e3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhy0EoqVw4AWQJS5wSDuO48Q5omopSKtygXPkOJPtVI6z2M5We-MR4BV5krpsqSok5jJ_9Ok7zI-x1wJORa4z9HgqpAJ4wo5FVetCSCme5lkqUSgB4oi9iPEaAMqmhOfsqGxBl6qpj9mv9ew3lJaBvHHcziGRzUO6Iu_Jb7jxQ75uPCXaIR_QOvLIyfOtSYQ-RX5D6YqjCW7_-8dPvsMQl8idSZjXmMwGeVz6B_HORLs4E_hE7rGZpq2hMGXjS_ZsNC7iq_t-wr59XH09_1Ssv1x8Pv-wLqxUEgojbF8qqMcKwOixaQds9CCtQguVktZKUKBsZRqhRT22ZpAGpdSgdC96jfKEvTt4t2H-vmBM3UTRonPG47zETrSqaWoNDWT07T_o9byE_LA7SreqlrWoMvX-QNkwxxhw7LaBJhP2nYDuLqcu59T9ySmzb-6NSz_h8ED-DSYDZwfghhzu_2_qVperg_IWsC6g5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1989563614</pqid></control><display><type>article</type><title>Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, J. ; Seo, S. W. ; Yang, J.‐J. ; Jang, Y. K. ; Lee, J. S. ; Kim, Y. J. ; Chin, J. ; Lee, J. M. ; Kim, S. T. ; Lee, K.‐H. ; Lee, J. H. ; Kim, J. S. ; Kim, S. ; Yoo, H. ; Lee, A. Y. ; Na, D. L. ; Kim, H. J.</creator><creatorcontrib>Lee, J. ; Seo, S. W. ; Yang, J.‐J. ; Jang, Y. K. ; Lee, J. S. ; Kim, Y. J. ; Chin, J. ; Lee, J. M. ; Kim, S. T. ; Lee, K.‐H. ; Lee, J. H. ; Kim, J. S. ; Kim, S. ; Yoo, H. ; Lee, A. Y. ; Na, D. L. ; Kim, H. J.</creatorcontrib><description>Background and purpose
Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.
Methods
Seventy‐two svMCI patients were divided into early stage (ES‐svMCI, n = 39) and late stage (LS‐svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.
Results
There was no difference in the rate of increase in PiB uptake or lacune number between the ES‐svMCI and LS‐svMCI. However, LS‐svMCI showed more rapid cortical thinning and cognitive decline than did the ES‐svMCI.
Conclusions
We suggest that, whilst the rate of change in pathological burden did not differ between ES‐svMCI and LS‐svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS‐svMCI.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.13500</identifier><identifier>PMID: 29082576</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Amyloid ; Biomarkers ; Brain ; Cerebral Cortex - diagnostic imaging ; Cerebral Small Vessel Diseases - complications ; Cerebral Small Vessel Diseases - diagnostic imaging ; cognition ; Cognitive ability ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Cortex ; cortical thickness ; Dementia disorders ; Disease Progression ; early stage ; Female ; Humans ; Impairment ; late stage ; Longitudinal Studies ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Mental competency ; Neuroimaging ; Neuropsychological Tests ; Patients ; Positron emission ; Positron emission tomography ; Positron-Emission Tomography - methods ; subcortical vascular mild cognitive impairment ; Thinning</subject><ispartof>European journal of neurology, 2018-02, Vol.25 (2), p.326-333</ispartof><rights>2017 EAN</rights><rights>2017 EAN.</rights><rights>Copyright © 2018 European Academy of Neurology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-a1cb2506f400a8f79de78d3c5ec0453cc30505c4a71816f9ad3ae338058b1b8e3</citedby><cites>FETCH-LOGICAL-c3530-a1cb2506f400a8f79de78d3c5ec0453cc30505c4a71816f9ad3ae338058b1b8e3</cites><orcidid>0000-0002-5017-854X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.13500$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.13500$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29082576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, J.</creatorcontrib><creatorcontrib>Seo, S. W.</creatorcontrib><creatorcontrib>Yang, J.‐J.</creatorcontrib><creatorcontrib>Jang, Y. K.</creatorcontrib><creatorcontrib>Lee, J. S.</creatorcontrib><creatorcontrib>Kim, Y. J.</creatorcontrib><creatorcontrib>Chin, J.</creatorcontrib><creatorcontrib>Lee, J. M.</creatorcontrib><creatorcontrib>Kim, S. T.</creatorcontrib><creatorcontrib>Lee, K.‐H.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><creatorcontrib>Kim, J. S.</creatorcontrib><creatorcontrib>Kim, S.</creatorcontrib><creatorcontrib>Yoo, H.</creatorcontrib><creatorcontrib>Lee, A. Y.</creatorcontrib><creatorcontrib>Na, D. L.</creatorcontrib><creatorcontrib>Kim, H. J.</creatorcontrib><title>Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.
Methods
Seventy‐two svMCI patients were divided into early stage (ES‐svMCI, n = 39) and late stage (LS‐svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.
Results
There was no difference in the rate of increase in PiB uptake or lacune number between the ES‐svMCI and LS‐svMCI. However, LS‐svMCI showed more rapid cortical thinning and cognitive decline than did the ES‐svMCI.
Conclusions
We suggest that, whilst the rate of change in pathological burden did not differ between ES‐svMCI and LS‐svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS‐svMCI.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyloid</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - complications</subject><subject>Cerebral Small Vessel Diseases - diagnostic imaging</subject><subject>cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cortex</subject><subject>cortical thickness</subject><subject>Dementia disorders</subject><subject>Disease Progression</subject><subject>early stage</subject><subject>Female</subject><subject>Humans</subject><subject>Impairment</subject><subject>late stage</subject><subject>Longitudinal Studies</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Mental competency</subject><subject>Neuroimaging</subject><subject>Neuropsychological Tests</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>subcortical vascular mild cognitive impairment</subject><subject>Thinning</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhy0EoqVw4AWQJS5wSDuO48Q5omopSKtygXPkOJPtVI6z2M5We-MR4BV5krpsqSok5jJ_9Ok7zI-x1wJORa4z9HgqpAJ4wo5FVetCSCme5lkqUSgB4oi9iPEaAMqmhOfsqGxBl6qpj9mv9ew3lJaBvHHcziGRzUO6Iu_Jb7jxQ75uPCXaIR_QOvLIyfOtSYQ-RX5D6YqjCW7_-8dPvsMQl8idSZjXmMwGeVz6B_HORLs4E_hE7rGZpq2hMGXjS_ZsNC7iq_t-wr59XH09_1Ssv1x8Pv-wLqxUEgojbF8qqMcKwOixaQds9CCtQguVktZKUKBsZRqhRT22ZpAGpdSgdC96jfKEvTt4t2H-vmBM3UTRonPG47zETrSqaWoNDWT07T_o9byE_LA7SreqlrWoMvX-QNkwxxhw7LaBJhP2nYDuLqcu59T9ySmzb-6NSz_h8ED-DSYDZwfghhzu_2_qVperg_IWsC6g5A</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Lee, J.</creator><creator>Seo, S. W.</creator><creator>Yang, J.‐J.</creator><creator>Jang, Y. K.</creator><creator>Lee, J. S.</creator><creator>Kim, Y. J.</creator><creator>Chin, J.</creator><creator>Lee, J. M.</creator><creator>Kim, S. T.</creator><creator>Lee, K.‐H.</creator><creator>Lee, J. H.</creator><creator>Kim, J. S.</creator><creator>Kim, S.</creator><creator>Yoo, H.</creator><creator>Lee, A. Y.</creator><creator>Na, D. L.</creator><creator>Kim, H. J.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5017-854X</orcidid></search><sort><creationdate>201802</creationdate><title>Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment</title><author>Lee, J. ; Seo, S. W. ; Yang, J.‐J. ; Jang, Y. K. ; Lee, J. S. ; Kim, Y. J. ; Chin, J. ; Lee, J. M. ; Kim, S. T. ; Lee, K.‐H. ; Lee, J. H. ; Kim, J. S. ; Kim, S. ; Yoo, H. ; Lee, A. Y. ; Na, D. L. ; Kim, H. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-a1cb2506f400a8f79de78d3c5ec0453cc30505c4a71816f9ad3ae338058b1b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyloid</topic><topic>Biomarkers</topic><topic>Brain</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - complications</topic><topic>Cerebral Small Vessel Diseases - diagnostic imaging</topic><topic>cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cortex</topic><topic>cortical thickness</topic><topic>Dementia disorders</topic><topic>Disease Progression</topic><topic>early stage</topic><topic>Female</topic><topic>Humans</topic><topic>Impairment</topic><topic>late stage</topic><topic>Longitudinal Studies</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Mental competency</topic><topic>Neuroimaging</topic><topic>Neuropsychological Tests</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>subcortical vascular mild cognitive impairment</topic><topic>Thinning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, J.</creatorcontrib><creatorcontrib>Seo, S. W.</creatorcontrib><creatorcontrib>Yang, J.‐J.</creatorcontrib><creatorcontrib>Jang, Y. K.</creatorcontrib><creatorcontrib>Lee, J. S.</creatorcontrib><creatorcontrib>Kim, Y. J.</creatorcontrib><creatorcontrib>Chin, J.</creatorcontrib><creatorcontrib>Lee, J. M.</creatorcontrib><creatorcontrib>Kim, S. T.</creatorcontrib><creatorcontrib>Lee, K.‐H.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><creatorcontrib>Kim, J. S.</creatorcontrib><creatorcontrib>Kim, S.</creatorcontrib><creatorcontrib>Yoo, H.</creatorcontrib><creatorcontrib>Lee, A. Y.</creatorcontrib><creatorcontrib>Na, D. L.</creatorcontrib><creatorcontrib>Kim, H. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, J.</au><au>Seo, S. W.</au><au>Yang, J.‐J.</au><au>Jang, Y. K.</au><au>Lee, J. S.</au><au>Kim, Y. J.</au><au>Chin, J.</au><au>Lee, J. M.</au><au>Kim, S. T.</au><au>Lee, K.‐H.</au><au>Lee, J. H.</au><au>Kim, J. S.</au><au>Kim, S.</au><au>Yoo, H.</au><au>Lee, A. Y.</au><au>Na, D. L.</au><au>Kim, H. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2018-02</date><risdate>2018</risdate><volume>25</volume><issue>2</issue><spage>326</spage><epage>333</epage><pages>326-333</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><abstract>Background and purpose
Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.
Methods
Seventy‐two svMCI patients were divided into early stage (ES‐svMCI, n = 39) and late stage (LS‐svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [11C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.
Results
There was no difference in the rate of increase in PiB uptake or lacune number between the ES‐svMCI and LS‐svMCI. However, LS‐svMCI showed more rapid cortical thinning and cognitive decline than did the ES‐svMCI.
Conclusions
We suggest that, whilst the rate of change in pathological burden did not differ between ES‐svMCI and LS‐svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS‐svMCI.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>29082576</pmid><doi>10.1111/ene.13500</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5017-854X</orcidid></addata></record> |
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| subjects | Aged Aged, 80 and over Amyloid Biomarkers Brain Cerebral Cortex - diagnostic imaging Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - diagnostic imaging cognition Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Cortex cortical thickness Dementia disorders Disease Progression early stage Female Humans Impairment late stage Longitudinal Studies Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Mental competency Neuroimaging Neuropsychological Tests Patients Positron emission Positron emission tomography Positron-Emission Tomography - methods subcortical vascular mild cognitive impairment Thinning |
| title | Longitudinal cortical thinning and cognitive decline in patients with early‐ versus late‐stage subcortical vascular mild cognitive impairment |
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