Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains
•When several new vaccines are available, the sequence of vaccine introduction affects health gains.•A new model is presented that can help decision-makers to optimize vaccine introduction.•For Japan, the model estimates that 500 billion Yen achieve a QALY gain of 72,288.•Without optimization, the s...
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| Veröffentlicht in: | Health policy (Amsterdam) 2017-12, Vol.121 (12), p.1303-1312 |
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| creator | Standaert, Baudouin Schecroun, Nadia Ethgen, Olivier Topachevskyi, Oleksandr Morioka, Yoriko Van Vlaenderen, Ilse |
| description | •When several new vaccines are available, the sequence of vaccine introduction affects health gains.•A new model is presented that can help decision-makers to optimize vaccine introduction.•For Japan, the model estimates that 500 billion Yen achieve a QALY gain of 72,288.•Without optimization, the same budget would achieve a 20% lower QALY gain.
Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints.
Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages. Operating under budget constraints, the Portfolio-model for the Management of Vaccines (PMV) identifies the optimal vaccine ranking and combination for achieving the maximum QALY gain over a period of 10 calendar years in children |
| doi_str_mv | 10.1016/j.healthpol.2017.08.010 |
| format | Article |
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Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints.
Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages. Operating under budget constraints, the Portfolio-model for the Management of Vaccines (PMV) identifies the optimal vaccine ranking and combination for achieving the maximum QALY gain over a period of 10 calendar years in children <5 years old. This vaccine strategy, of interest and helpful for a healthcare decision maker, is compared with an unranked vaccine selection process.
Results indicate that the maximum QALY gain with a fixed annual vaccination budget of 500 billion Japanese Yen over a 10-year period is 72,288 QALYs using the optimal sequence of vaccine introduction (mumps [1st], followed by influenza [2nd], rotavirus [3rd], and pneumococcal [4th]). With exactly the same budget but without vaccine ranking, the total QALY gain can be 20% lower.
The PMV model could be a helpful tool for decision makers in those environments with limited budget where vaccines have to be selected for trying to optimise specific health goals.</description><identifier>ISSN: 0168-8510</identifier><identifier>EISSN: 1872-6054</identifier><identifier>DOI: 10.1016/j.healthpol.2017.08.010</identifier><identifier>PMID: 29079394</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Budget ; Budget constraint ; Child, Preschool ; Childhood ; Children & youth ; Cost-Benefit Analysis - methods ; Decision makers ; Health administration ; Health care ; Health services ; Humans ; Immunization ; Immunization Programs - economics ; Immunization Programs - organization & administration ; Infant ; Infectious diseases ; Influenza ; Japan ; Models, Statistical ; Mumps ; Objective function ; Objectives ; Optimisation model ; Optimization ; Pediatrics ; Pneumococcal disease ; Portfolio ; Prioritizing ; Public health ; Quality adjusted life years ; Ratings & rankings ; Rotavirus ; Vaccination - economics ; Vaccine ; Vaccines ; Vaccines - economics</subject><ispartof>Health policy (Amsterdam), 2017-12, Vol.121 (12), p.1303-1312</ispartof><rights>2017 GlaxoSmithKline Biologicals SA</rights><rights>Copyright © 2017 GlaxoSmithKline Biologicals SA. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Dec 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-2bce13ef42cc80a0834db3f824704cbdc2ec803897d3f65a19cd2be096428c933</citedby><cites>FETCH-LOGICAL-c448t-2bce13ef42cc80a0834db3f824704cbdc2ec803897d3f65a19cd2be096428c933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.healthpol.2017.08.010$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27866,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29079394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Standaert, Baudouin</creatorcontrib><creatorcontrib>Schecroun, Nadia</creatorcontrib><creatorcontrib>Ethgen, Olivier</creatorcontrib><creatorcontrib>Topachevskyi, Oleksandr</creatorcontrib><creatorcontrib>Morioka, Yoriko</creatorcontrib><creatorcontrib>Van Vlaenderen, Ilse</creatorcontrib><title>Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains</title><title>Health policy (Amsterdam)</title><addtitle>Health Policy</addtitle><description>•When several new vaccines are available, the sequence of vaccine introduction affects health gains.•A new model is presented that can help decision-makers to optimize vaccine introduction.•For Japan, the model estimates that 500 billion Yen achieve a QALY gain of 72,288.•Without optimization, the same budget would achieve a 20% lower QALY gain.
Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints.
Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages. Operating under budget constraints, the Portfolio-model for the Management of Vaccines (PMV) identifies the optimal vaccine ranking and combination for achieving the maximum QALY gain over a period of 10 calendar years in children <5 years old. This vaccine strategy, of interest and helpful for a healthcare decision maker, is compared with an unranked vaccine selection process.
Results indicate that the maximum QALY gain with a fixed annual vaccination budget of 500 billion Japanese Yen over a 10-year period is 72,288 QALYs using the optimal sequence of vaccine introduction (mumps [1st], followed by influenza [2nd], rotavirus [3rd], and pneumococcal [4th]). With exactly the same budget but without vaccine ranking, the total QALY gain can be 20% lower.
The PMV model could be a helpful tool for decision makers in those environments with limited budget where vaccines have to be selected for trying to optimise specific health goals.</description><subject>Budget</subject><subject>Budget constraint</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children & youth</subject><subject>Cost-Benefit Analysis - methods</subject><subject>Decision makers</subject><subject>Health administration</subject><subject>Health care</subject><subject>Health services</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Programs - economics</subject><subject>Immunization Programs - organization & administration</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Japan</subject><subject>Models, Statistical</subject><subject>Mumps</subject><subject>Objective function</subject><subject>Objectives</subject><subject>Optimisation model</subject><subject>Optimization</subject><subject>Pediatrics</subject><subject>Pneumococcal disease</subject><subject>Portfolio</subject><subject>Prioritizing</subject><subject>Public health</subject><subject>Quality adjusted life years</subject><subject>Ratings & rankings</subject><subject>Rotavirus</subject><subject>Vaccination - economics</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines - economics</subject><issn>0168-8510</issn><issn>1872-6054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>7TQ</sourceid><recordid>eNqFkc2O0zAUhS0EYsrAK4AlNmwSrn8aO-yqEb8aaTawthz7pnGVxiF2KvEcvDCuOjMLhMTKkvWd4-NzCHnDoGbAmveHekA75mGOY82BqRp0DQyekA3TilcNbOVTsimkrvSWwRV5kdIBAJQQzXNyxVtQrWjlhvy-m3M4hhSmPc0D0jDlJfrV5RAnGnt6XMcc5hGpG8Lohxg9PVnnwoSpsPSbne30ge7oMXoc6bzEOf7bK-HPFSeH1BYnPD0wQ9gPmDK9fIfubZjSS_Kst2PCV_fnNfnx6eP3my_V7d3nrze728pJqXPFO4dMYC-5cxosaCF9J3rNpQLpOu84lnuhW-VF32wta53nHULbSK5dK8Q1eXfxLbFLuJRNKcLhONoJ45oMa7dKthKkLujbv9BDXJeppDOlfikE8EYVSl0ot8SUFuzNvISjXX4ZBua8mzmYx93OQmVAm7JbUb6-91-7I_pH3cNQBdhdACyFnAIuJrlw7tOHBV02Pob_PvIH6NOwog</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Standaert, Baudouin</creator><creator>Schecroun, Nadia</creator><creator>Ethgen, Olivier</creator><creator>Topachevskyi, Oleksandr</creator><creator>Morioka, Yoriko</creator><creator>Van Vlaenderen, Ilse</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TQ</scope><scope>8BJ</scope><scope>DHY</scope><scope>DON</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains</title><author>Standaert, Baudouin ; Schecroun, Nadia ; Ethgen, Olivier ; Topachevskyi, Oleksandr ; Morioka, Yoriko ; Van Vlaenderen, Ilse</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-2bce13ef42cc80a0834db3f824704cbdc2ec803897d3f65a19cd2be096428c933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Budget</topic><topic>Budget constraint</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children & youth</topic><topic>Cost-Benefit Analysis - methods</topic><topic>Decision makers</topic><topic>Health administration</topic><topic>Health care</topic><topic>Health services</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Programs - economics</topic><topic>Immunization Programs - organization & administration</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Japan</topic><topic>Models, Statistical</topic><topic>Mumps</topic><topic>Objective function</topic><topic>Objectives</topic><topic>Optimisation model</topic><topic>Optimization</topic><topic>Pediatrics</topic><topic>Pneumococcal disease</topic><topic>Portfolio</topic><topic>Prioritizing</topic><topic>Public health</topic><topic>Quality adjusted life years</topic><topic>Ratings & rankings</topic><topic>Rotavirus</topic><topic>Vaccination - economics</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Vaccines - economics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Standaert, Baudouin</creatorcontrib><creatorcontrib>Schecroun, Nadia</creatorcontrib><creatorcontrib>Ethgen, Olivier</creatorcontrib><creatorcontrib>Topachevskyi, Oleksandr</creatorcontrib><creatorcontrib>Morioka, Yoriko</creatorcontrib><creatorcontrib>Van Vlaenderen, Ilse</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>PAIS Index</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><jtitle>Health policy (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Standaert, Baudouin</au><au>Schecroun, Nadia</au><au>Ethgen, Olivier</au><au>Topachevskyi, Oleksandr</au><au>Morioka, Yoriko</au><au>Van Vlaenderen, Ilse</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains</atitle><jtitle>Health policy (Amsterdam)</jtitle><addtitle>Health Policy</addtitle><date>2017-12</date><risdate>2017</risdate><volume>121</volume><issue>12</issue><spage>1303</spage><epage>1312</epage><pages>1303-1312</pages><issn>0168-8510</issn><eissn>1872-6054</eissn><abstract>•When several new vaccines are available, the sequence of vaccine introduction affects health gains.•A new model is presented that can help decision-makers to optimize vaccine introduction.•For Japan, the model estimates that 500 billion Yen achieve a QALY gain of 72,288.•Without optimization, the same budget would achieve a 20% lower QALY gain.
Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints.
Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages. Operating under budget constraints, the Portfolio-model for the Management of Vaccines (PMV) identifies the optimal vaccine ranking and combination for achieving the maximum QALY gain over a period of 10 calendar years in children <5 years old. This vaccine strategy, of interest and helpful for a healthcare decision maker, is compared with an unranked vaccine selection process.
Results indicate that the maximum QALY gain with a fixed annual vaccination budget of 500 billion Japanese Yen over a 10-year period is 72,288 QALYs using the optimal sequence of vaccine introduction (mumps [1st], followed by influenza [2nd], rotavirus [3rd], and pneumococcal [4th]). With exactly the same budget but without vaccine ranking, the total QALY gain can be 20% lower.
The PMV model could be a helpful tool for decision makers in those environments with limited budget where vaccines have to be selected for trying to optimise specific health goals.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29079394</pmid><doi>10.1016/j.healthpol.2017.08.010</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Budget Budget constraint Child, Preschool Childhood Children & youth Cost-Benefit Analysis - methods Decision makers Health administration Health care Health services Humans Immunization Immunization Programs - economics Immunization Programs - organization & administration Infant Infectious diseases Influenza Japan Models, Statistical Mumps Objective function Objectives Optimisation model Optimization Pediatrics Pneumococcal disease Portfolio Prioritizing Public health Quality adjusted life years Ratings & rankings Rotavirus Vaccination - economics Vaccine Vaccines Vaccines - economics |
| title | Optimising the introduction of multiple childhood vaccines in Japan: A model proposing the introduction sequence achieving the highest health gains |
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