HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Targeted therapy against VEGF and mTOR pathways has been established as the standard-of-care for metastatic clear cell renal cell carcinoma (ccRCC); however, these treatments frequently fail and most patients become refractory requiring subsequent alternative therapeutic options. Therefore, developm...

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Veröffentlicht in:	Molecular cancer therapeutics 2018-01, Vol.17 (1), p.140-149
Hauptverfasser:	Wong, So C, Cheng, Weijun, Hamilton, Holly, Nicholas, Anthony L, Wakefield, Darren H, Almeida, Aaron, Blokhin, Andrei V, Carlson, Jeffrey, Neal, Zane C, Subbotin, Vladimir, Zhang, Guofeng, Hegge, Julia, Bertin, Stephanie, Trubetskoy, Vladimir S, Rozema, David B, Lewis, David L, Kanner, Steven B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - therapy Cell Line, Tumor Clear cell-type renal cell carcinoma Degeneration Female Gene Silencing Growth inhibition Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Integrin alphaVbeta3 - metabolism Integrins Metastases Mice Mice, Nude Neoplasia Receptors, Vitronectin - metabolism RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA-mediated interference TOR protein Tumors Ubiquitin Ubiquitin-protein ligase Vascular endothelial growth factor VHL protein Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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