Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses

To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising m...

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Veröffentlicht in:Urology (Ridgewood, N.J.) N.J.), 2018-02, Vol.112, p.103-111
Hauptverfasser: Woldu, Solomon L., Aydin, Ahmet M., Rao, Ashwin V., Hutchinson, Ryan C., Singla, Nirmish, Clinton, Timothy N., Krabbe, Laura-Maria, Passoni, Niccolo M., Raj, Ganesh V., Miller, David S., Amatruda, James F., Sagalowsky, Arthur I., Lotan, Yair, Arriaga, Yull, Margulis, Vitaly, Bagrodia, Aditya
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container_start_page 103
container_title Urology (Ridgewood, N.J.)
container_volume 112
creator Woldu, Solomon L.
Aydin, Ahmet M.
Rao, Ashwin V.
Hutchinson, Ryan C.
Singla, Nirmish
Clinton, Timothy N.
Krabbe, Laura-Maria
Passoni, Niccolo M.
Raj, Ganesh V.
Miller, David S.
Amatruda, James F.
Sagalowsky, Arthur I.
Lotan, Yair
Arriaga, Yull
Margulis, Vitaly
Bagrodia, Aditya
description To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidly in this demographic, yet little is known about TGCTs in Hispanic patients. We compared patient factors, tumor characteristics, treatment patterns, and outcomes of non-Hispanic white (NHW) vs Hispanic patients at our own institution in North Texas from 2010 to 2016. The findings were corroborated by analyzing the National Cancer Database testicular cancer registry from 2004 to 2014. We identified 154 patients with TGCT at our institution, of which 89 were NHW (56.0%) and 65 were Hispanic (40.9%). A review of the National Cancer Database identified 49,607 NHW patients (81.5%) and 6724 Hispanic patients (11.0%) diagnosed with TGCT. At presentation, Hispanic patients were approximately 5 years younger than NHW patients, delay seeking care for testicular cancer, were more likely to have nonseminomatous histology, had a larger tumor size, and had a higher disease burden at presentation. Additionally, we identified differences in treatment patterns at the national level. Differences in outcomes and treatment patterns of Hispanic and NHW patients with TGCT may represent underlying socioeconomic issues and access to care; however, discrepancies in age of onset and histology of TGCT between Hispanic and NHW patients may signify differences in tumor biology or risk factors. We suggest that this possibility be explored further as we embark upon the genomic classification of TGCT.
doi_str_mv 10.1016/j.urology.2017.08.059
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Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidly in this demographic, yet little is known about TGCTs in Hispanic patients. We compared patient factors, tumor characteristics, treatment patterns, and outcomes of non-Hispanic white (NHW) vs Hispanic patients at our own institution in North Texas from 2010 to 2016. The findings were corroborated by analyzing the National Cancer Database testicular cancer registry from 2004 to 2014. We identified 154 patients with TGCT at our institution, of which 89 were NHW (56.0%) and 65 were Hispanic (40.9%). A review of the National Cancer Database identified 49,607 NHW patients (81.5%) and 6724 Hispanic patients (11.0%) diagnosed with TGCT. At presentation, Hispanic patients were approximately 5 years younger than NHW patients, delay seeking care for testicular cancer, were more likely to have nonseminomatous histology, had a larger tumor size, and had a higher disease burden at presentation. Additionally, we identified differences in treatment patterns at the national level. Differences in outcomes and treatment patterns of Hispanic and NHW patients with TGCT may represent underlying socioeconomic issues and access to care; however, discrepancies in age of onset and histology of TGCT between Hispanic and NHW patients may signify differences in tumor biology or risk factors. 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subjects Adult
Health Facilities
Hispanic Americans
Humans
Male
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal - epidemiology
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - therapy
Registries
Testicular Neoplasms - epidemiology
Testicular Neoplasms - pathology
Testicular Neoplasms - therapy
United States - epidemiology
title Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses
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