IL-17 Activates the IL-6/STAT3 Signal Pathway in the Proliferation of Hepatitis B Virus-Related Hepatocellular Carcinoma

Background/Aims: We performed this study to determine the role of IL-17 in the immune microenvironment of hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). Methods: HepG2 cells were treated with IL-17, STAT3 inhibitor S31-201 or IL-6 neutralizing monoclonal antibody (IL-6 mAb). Cell...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.43 (6), p.2379-2390
Hauptverfasser:	Hu, Zongqiang, Luo, Ding, Wang, Dongdong, Ma, Linjie, Zhao, Yingpeng, Li, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - pharmacology Breast cancer Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell growth Cell Movement - drug effects Cell Proliferation - drug effects Chemokine CCL2 - analysis Chemokine CCL5 - analysis Cytokines Disease Models, Animal Female HBV HCC Hep G2 Cells Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - pathology Hepatitis B - virology Hepatitis B virus - physiology Humans IL-17 IL-6 Infections Inflammation Interleukin-17 - genetics Interleukin-17 - metabolism Interleukin-17 - pharmacology Interleukin-6 - analysis Interleukin-6 - immunology Liver cancer Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Mice, Inbred BALB C Mice, Knockout Microscopy, Fluorescence Original Paper Phosphorylation Phosphorylation - drug effects Proteins pSTAT3 Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - pharmacology Signal Transduction - drug effects STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Transplantation, Heterologous Vascular Endothelial Growth Factor A - analysis
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