G‐Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy

A curated library of circular dichroism spectra of 23 G‐quadruplexes of known structure was built and analyzed. The goal of this study was to use this reference library to develop an algorithm to derive quantitative estimates of the secondary structure content of quadruplexes from their experimental...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-06, Vol.57 (24), p.7171-7175
Hauptverfasser:	del Villar‐Guerra, Rafael, Trent, John O., Chaires, Jonathan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Cattle Circular dichroism Circular Dichroism - methods Dichroism DNA DNA - chemistry G-Quadruplexes Libraries Models, Molecular Nucleic Acid Conformation Nucleic acids Principal components analysis Protein CD Protein structure Proteins Secondary structure Singular value decomposition Spectra Spectroscopy Spectrum analysis
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