Induction of drug metabolism: Species differences and toxicological relevance

Abstract A large number of drugs and other chemicals have been shown to induce hepatic microsomal cytochrome P450 (CYP) forms in experimental animals and humans. Most CYP forms are induced by receptor-mediated mechanisms leading to an increase in gene transcription. Important nuclear receptors invol...

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Veröffentlicht in:	Toxicology (Amsterdam) 2008-12, Vol.254 (3), p.184-191
Hauptverfasser:	Graham, Mark J, Lake, Brian G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Drug Interactions Drug-Related Side Effects and Adverse Reactions Emergency Enzyme Induction - drug effects Humans Induction of hepatic xenobiotic metabolism Liver - enzymology Medical sciences Mode of action Neoplasms - chemically induced Non-genotoxic carcinogenesis Nuclear receptors Pharmaceutical Preparations - metabolism Species differences Species Specificity Toxicology Transcription, Genetic Tumors
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