Dihydropteridine reductase deficiency : Levodopa's long-term effectiveness without dyskinesia

We report an adult patient lacking endogenous synthesis of monoamines (dopamine, serotonin, and catecholamines) due to a severe dihydropteridine reductase (DHPR) deficiency. With levodopa and 5-hydroxytryptophan (5HTP) supplementation, the patient exhibited moderate mental retardation, acute episode...

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Veröffentlicht in:	Neurology 2006-12, Vol.67 (12), p.2243-2245
Hauptverfasser:	SEDEL, F, RIBEIRO, M. J, REMY, P, BLAU, N, SAUDUBRAY, J.-M, AGID, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - therapeutic use Adult Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Agents - therapeutic use Drug Combinations Drug toxicity and drugs side effects treatment Dyskinesia, Drug-Induced - etiology Dyskinesias Humans Levodopa - therapeutic use Longitudinal Studies Male Medical sciences Neurology Pharmacology. Drug treatments Phenylketonurias - diagnosis Phenylketonurias - drug therapy Toxicity: nervous system and muscle Treatment Outcome
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