beta -PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrP super(Sc)
Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrP super(Sc)) of host-encoded prion protein (PrP super(C)). PrP super(Sc) is characterised by increased beta -sheet content, detergent insolubility and protease resistance. Recombin...
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Veröffentlicht in: | Biochimica et biophysica acta. Proteins and proteomics 2007-11, Vol.1774 (11), p.1438-1450 |
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Sprache: | eng |
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