Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo
Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-...
Gespeichert in:
| Veröffentlicht in: | Journal of bone and joint surgery. British volume 2008-08, Vol.90 (8), p.1106-1113 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1113 |
|---|---|
| container_issue | 8 |
| container_start_page | 1106 |
| container_title | Journal of bone and joint surgery. British volume |
| container_volume | 90 |
| creator | RICHARDS, L BROWN, C STONE, M. H FISHER, J INGHAM, E TIPPER, J. L |
| description | Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debris were generated in vivo. A randomised method of analysis was used to quantify and characterise all the polyethylene particles isolated. We isolated nanometre-sized particles from the retrieved tissue samples. The smallest identified was 30 nm and the majority were in the 0.1 microm to 0.99 microm size range. Particles in the 1.0 microm to 9.99 microm size range represented the highest proportion of the wear volume of the tissue samples, with 35% to 98% of the total wear volume comprised of particles of this size. The number of nanometre-sized particles isolated from the tissues accounted for only a small proportion of the total wear volume. Further work is required to assess the biological response to nanometre-sized polyethylene particles. |
| doi_str_mv | 10.1302/0301-620x.90b8.20737 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19569791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1542325491</sourcerecordid><originalsourceid>FETCH-LOGICAL-c556t-a4144b16fb3853fa70895c589374970759ef116aef4a9233f25f22b5ffd9ef943</originalsourceid><addsrcrecordid>eNpdkduKFDEQhoMo7rj6BiKNoHc95tjpXOriYWHBGwXvQjpTcbKkkzZJj45Pb8YdFbyq01c_Rf0IPSV4SximrzDDpB8o_rFVeBq3FEsm76ENxZz3gkl5H23-IF8u0KNSbjHGXAj2EF2QcRiUknSDDtc7iNU7b031KXbJddHENEPN0Bf_E3bdGmo2_d5_3XdzCmDXYHL3HVpduyWFI9T9MUCE1muDxeTqbYDS-dgVMy-nNDc5D4cm1poHf0iP0QNnQoEn53iJPr97--nqQ3_z8f311eub3gox1N5wwvlEBjexUTBnJB6VsGJUTHIlsRQKHCGDAceNoow5Khylk3Bu1yaKs0v08k53yenbCqXq2RcLIZgIaS2aKDEoqUgDn_8H3qY1x3abplQNimBGG8TvIJtTKRmcXrKfTT5qgvXJFH36uD59XCv8ZtS_TWlrz87a6zTD7t_S2YUGvDgDplgTXDbR-vKXo1gIQsnAfgGqx5aB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229691032</pqid></control><display><type>article</type><title>Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>RICHARDS, L ; BROWN, C ; STONE, M. H ; FISHER, J ; INGHAM, E ; TIPPER, J. L</creator><creatorcontrib>RICHARDS, L ; BROWN, C ; STONE, M. H ; FISHER, J ; INGHAM, E ; TIPPER, J. L</creatorcontrib><description>Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debris were generated in vivo. A randomised method of analysis was used to quantify and characterise all the polyethylene particles isolated. We isolated nanometre-sized particles from the retrieved tissue samples. The smallest identified was 30 nm and the majority were in the 0.1 microm to 0.99 microm size range. Particles in the 1.0 microm to 9.99 microm size range represented the highest proportion of the wear volume of the tissue samples, with 35% to 98% of the total wear volume comprised of particles of this size. The number of nanometre-sized particles isolated from the tissues accounted for only a small proportion of the total wear volume. Further work is required to assess the biological response to nanometre-sized polyethylene particles.</description><edition>British volume</edition><identifier>ISSN: 0301-620X</identifier><identifier>ISSN: 2049-4394</identifier><identifier>EISSN: 2044-5377</identifier><identifier>EISSN: 2049-4408</identifier><identifier>DOI: 10.1302/0301-620x.90b8.20737</identifier><identifier>PMID: 18669972</identifier><identifier>CODEN: JBSUAK</identifier><language>eng</language><publisher>London: British Editorial Society of Bone and Joint Surgery</publisher><subject>Arthroplasty, Replacement, Hip - methods ; Arthroplasty, Replacement, Hip - standards ; Biocompatible Materials - isolation & purification ; Biological and medical sciences ; Diseases of the osteoarticular system ; Hip Prosthesis ; Humans ; Lubricants ; Lubrication ; Medical sciences ; Nanoparticles - analysis ; Orthopedic surgery ; Polyethylenes - analysis ; Polyethylenes - isolation & purification ; Prosthesis Design ; Prosthesis Failure ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors</subject><ispartof>Journal of bone and joint surgery. British volume, 2008-08, Vol.90 (8), p.1106-1113</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright British Editorial Society of Bone & Joint Surgery Aug 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-a4144b16fb3853fa70895c589374970759ef116aef4a9233f25f22b5ffd9ef943</citedby><cites>FETCH-LOGICAL-c556t-a4144b16fb3853fa70895c589374970759ef116aef4a9233f25f22b5ffd9ef943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20551216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18669972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RICHARDS, L</creatorcontrib><creatorcontrib>BROWN, C</creatorcontrib><creatorcontrib>STONE, M. H</creatorcontrib><creatorcontrib>FISHER, J</creatorcontrib><creatorcontrib>INGHAM, E</creatorcontrib><creatorcontrib>TIPPER, J. L</creatorcontrib><title>Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo</title><title>Journal of bone and joint surgery. British volume</title><addtitle>J Bone Joint Surg Br</addtitle><description>Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debris were generated in vivo. A randomised method of analysis was used to quantify and characterise all the polyethylene particles isolated. We isolated nanometre-sized particles from the retrieved tissue samples. The smallest identified was 30 nm and the majority were in the 0.1 microm to 0.99 microm size range. Particles in the 1.0 microm to 9.99 microm size range represented the highest proportion of the wear volume of the tissue samples, with 35% to 98% of the total wear volume comprised of particles of this size. The number of nanometre-sized particles isolated from the tissues accounted for only a small proportion of the total wear volume. Further work is required to assess the biological response to nanometre-sized polyethylene particles.</description><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Arthroplasty, Replacement, Hip - standards</subject><subject>Biocompatible Materials - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Hip Prosthesis</subject><subject>Humans</subject><subject>Lubricants</subject><subject>Lubrication</subject><subject>Medical sciences</subject><subject>Nanoparticles - analysis</subject><subject>Orthopedic surgery</subject><subject>Polyethylenes - analysis</subject><subject>Polyethylenes - isolation & purification</subject><subject>Prosthesis Design</subject><subject>Prosthesis Failure</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><issn>0301-620X</issn><issn>2049-4394</issn><issn>2044-5377</issn><issn>2049-4408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkduKFDEQhoMo7rj6BiKNoHc95tjpXOriYWHBGwXvQjpTcbKkkzZJj45Pb8YdFbyq01c_Rf0IPSV4SximrzDDpB8o_rFVeBq3FEsm76ENxZz3gkl5H23-IF8u0KNSbjHGXAj2EF2QcRiUknSDDtc7iNU7b031KXbJddHENEPN0Bf_E3bdGmo2_d5_3XdzCmDXYHL3HVpduyWFI9T9MUCE1muDxeTqbYDS-dgVMy-nNDc5D4cm1poHf0iP0QNnQoEn53iJPr97--nqQ3_z8f311eub3gox1N5wwvlEBjexUTBnJB6VsGJUTHIlsRQKHCGDAceNoow5Khylk3Bu1yaKs0v08k53yenbCqXq2RcLIZgIaS2aKDEoqUgDn_8H3qY1x3abplQNimBGG8TvIJtTKRmcXrKfTT5qgvXJFH36uD59XCv8ZtS_TWlrz87a6zTD7t_S2YUGvDgDplgTXDbR-vKXo1gIQsnAfgGqx5aB</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>RICHARDS, L</creator><creator>BROWN, C</creator><creator>STONE, M. H</creator><creator>FISHER, J</creator><creator>INGHAM, E</creator><creator>TIPPER, J. L</creator><general>British Editorial Society of Bone and Joint Surgery</general><general>British Editorial Society of Bone & Joint Surgery</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QP</scope></search><sort><creationdate>20080801</creationdate><title>Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo</title><author>RICHARDS, L ; BROWN, C ; STONE, M. H ; FISHER, J ; INGHAM, E ; TIPPER, J. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-a4144b16fb3853fa70895c589374970759ef116aef4a9233f25f22b5ffd9ef943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Arthroplasty, Replacement, Hip - standards</topic><topic>Biocompatible Materials - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Hip Prosthesis</topic><topic>Humans</topic><topic>Lubricants</topic><topic>Lubrication</topic><topic>Medical sciences</topic><topic>Nanoparticles - analysis</topic><topic>Orthopedic surgery</topic><topic>Polyethylenes - analysis</topic><topic>Polyethylenes - isolation & purification</topic><topic>Prosthesis Design</topic><topic>Prosthesis Failure</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RICHARDS, L</creatorcontrib><creatorcontrib>BROWN, C</creatorcontrib><creatorcontrib>STONE, M. H</creatorcontrib><creatorcontrib>FISHER, J</creatorcontrib><creatorcontrib>INGHAM, E</creatorcontrib><creatorcontrib>TIPPER, J. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of bone and joint surgery. British volume</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RICHARDS, L</au><au>BROWN, C</au><au>STONE, M. H</au><au>FISHER, J</au><au>INGHAM, E</au><au>TIPPER, J. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo</atitle><jtitle>Journal of bone and joint surgery. British volume</jtitle><addtitle>J Bone Joint Surg Br</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>90</volume><issue>8</issue><spage>1106</spage><epage>1113</epage><pages>1106-1113</pages><issn>0301-620X</issn><issn>2049-4394</issn><eissn>2044-5377</eissn><eissn>2049-4408</eissn><coden>JBSUAK</coden><abstract>Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debris were generated in vivo. A randomised method of analysis was used to quantify and characterise all the polyethylene particles isolated. We isolated nanometre-sized particles from the retrieved tissue samples. The smallest identified was 30 nm and the majority were in the 0.1 microm to 0.99 microm size range. Particles in the 1.0 microm to 9.99 microm size range represented the highest proportion of the wear volume of the tissue samples, with 35% to 98% of the total wear volume comprised of particles of this size. The number of nanometre-sized particles isolated from the tissues accounted for only a small proportion of the total wear volume. Further work is required to assess the biological response to nanometre-sized polyethylene particles.</abstract><cop>London</cop><pub>British Editorial Society of Bone and Joint Surgery</pub><pmid>18669972</pmid><doi>10.1302/0301-620x.90b8.20737</doi><tpages>8</tpages><edition>British volume</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-620X |
| ispartof | Journal of bone and joint surgery. British volume, 2008-08, Vol.90 (8), p.1106-1113 |
| issn | 0301-620X 2049-4394 2044-5377 2049-4408 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19569791 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Arthroplasty, Replacement, Hip - methods Arthroplasty, Replacement, Hip - standards Biocompatible Materials - isolation & purification Biological and medical sciences Diseases of the osteoarticular system Hip Prosthesis Humans Lubricants Lubrication Medical sciences Nanoparticles - analysis Orthopedic surgery Polyethylenes - analysis Polyethylenes - isolation & purification Prosthesis Design Prosthesis Failure Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors |
| title | Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T02%3A50%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20nanometre-sized%20ultra-high%20molecular%20weight%20polyethylene%20wear%20particles%20in%20samples%20retrieved%20in%20vivo&rft.jtitle=Journal%20of%20bone%20and%20joint%20surgery.%20British%20volume&rft.au=RICHARDS,%20L&rft.date=2008-08-01&rft.volume=90&rft.issue=8&rft.spage=1106&rft.epage=1113&rft.pages=1106-1113&rft.issn=0301-620X&rft.eissn=2044-5377&rft.coden=JBSUAK&rft_id=info:doi/10.1302/0301-620x.90b8.20737&rft_dat=%3Cproquest_cross%3E1542325491%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229691032&rft_id=info:pmid/18669972&rfr_iscdi=true |