Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo

Single-stranded RNA stimulates immune cells and induces the secretion of pro-inflammatory cytokines and type I IFN. As adjuvant RNA can induce a Th2 type of humoral response, however, its potency in the induction of cytotoxic T cells in vivo has not been analyzed. Here we show that immunization with...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunology 2007-03, Vol.19 (3), p.297-304
Hauptverfasser:	Hamm, Svetlana, Heit, Antje, Koffler, Martina, Huster, Katharina M., Akira, Shizuo, Busch, Dirk H., Wagner, Herrmann, Bauer, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - toxicity Animals Antibody Formation Antigens - immunology Bacterial Vaccines - immunology Bacterial Vaccines - toxicity Cells, Cultured Disease Models, Animal Fatty Acids, Monounsaturated - immunology Female IgG isotype Immunization Immunoglobulin G - blood innate immunity Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis - immunology Listeriosis - prevention & control Lymphocyte Activation Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Oligodeoxyribonucleotides - immunology Oligonucleotides - immunology Oligonucleotides - toxicity ovalbumin Ovalbumin - immunology Quaternary Ammonium Compounds - immunology RNA - immunology RNA - toxicity T-Lymphocytes, Cytotoxic - immunology Th2 Cells - immunology Toll-Like Receptor 7 - deficiency Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology Toll-like receptors vaccination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!