Proteomic approach for the analysis of acrylamide-hemoglobin adducts : Perspectives for biological monitoring

The formation of adducts between acrylamide and hemoglobin in vitro was investigated by using mass spectrometric methodologies to identify the amino acid residues sensitive to alkylation. Liquid chromatography-electrospray ionisation mass spectrometry analysis of either intact or trypsin-digested α-...

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Veröffentlicht in:	Journal of Chromatography A 2008-12, Vol.1215 (1-2), p.74-81
Hauptverfasser:	Basile, Adriana, Ferranti, Pasquale, Moccaldi, Roberto, Spagnoli, Giuseppe, Sannolo, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide - chemistry Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, High Pressure Liquid Environmental Monitoring - methods Hemoglobins - chemistry Medical sciences Peptide Mapping Proteomics Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Toxicology Trypsin Various organic compounds
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