Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain

Although functional studies demonstrate that noradrenaline controls the permeability of the blood–brain barrier, it has never been determined whether this neurotransmitter regulates the tight junction (TJ) assembly that confers the barrier property to brain microvessels. We thus tested in rats the e...

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Veröffentlicht in:	The European journal of neuroscience 2006-12, Vol.24 (12), p.3393-3400
Hauptverfasser:	Kalinin, Sergey, Feinstein, Douglas L., Xu, Hao-Liang, Huesa, Gema, Pelligrino, Dale A., Galea, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Autoantigens - metabolism Benzylamines - toxicity blood-brain barrier Blotting, Western - methods Brain - drug effects Brain - metabolism Brain - pathology Cell Count - methods Chromatography, High Pressure Liquid - methods Dose-Response Relationship, Drug Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry - methods Male Membrane Proteins - metabolism Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Nerve Degeneration - physiopathology noradrenaline Norepinephrine - metabolism occludin Phosphoproteins - metabolism Plant Lectins Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Tight Junctions - drug effects Tight Junctions - pathology Tyrosine 3-Monooxygenase - metabolism zonula occludens Zonula Occludens-1 Protein
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