XdhR negatively regulates actinorhodin biosynthesis in Streptomyces coelicolor M145

Abstract The xdhR gene encodes a TetR-family regulator in Streptomyces coelicolor. However, little is known about the function of XdhR in regulating actinorhodin production. Here, we report that XdhR negatively regulates actinorhodin biosynthesis in S. coelicolor. Deletion of xdhR resulted in overpr...

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Veröffentlicht in:	FEMS microbiology letters 2017-12, Vol.364 (22)
Hauptverfasser:	Fu, Jiafang, Zong, Gongli, Zhang, Peipei, Zhao, Zhilong, Ma, Junxia, Pang, Xiuhua, Cao, Guangxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinorhodin Anthraquinones - analysis Anthraquinones - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Biosynthesis Complementation Escherichia coli - genetics Gene Deletion Gene expression Gene Expression Regulation, Bacterial - genetics Genome, Bacterial Microbiology Promoter Regions, Genetic Protein Binding Recombinant Proteins - genetics Recombinant Proteins - metabolism Regulators Streptomyces coelicolor Streptomyces coelicolor - genetics Streptomyces coelicolor - metabolism Xanthine Dehydrogenase - genetics Xanthine Dehydrogenase - metabolism
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