Occult metabolic bone disease in chronic pancreatitis
Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP. We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP. In this cross-sectional, observational...
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| Veröffentlicht in: | Nigerian journal of clinical practice 2017-09, Vol.20 (9), p.1122-1126 |
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| creator | Kumar, Kvs Hari Sood, A K Manrai, M |
| description | Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP.
We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP.
In this cross-sectional, observational study, we included serial patients of CP in different stages and are grouped as ACP (Group 1; n = 67) and TCP (Group 2; n = 35). We determined serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D (25OHD), and intact parathyroid hormone (PTH) levels. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry in the neck of the left femur. MBD was defined by the presence of either low bone mass (Z-score Results: The study participants (85 males; 17 females) had a mean age of 40.8 ± 12.6 years, CP duration of 3.7 ± 4.7 years, and Body Mass Index of 22.5 ± 3.2 kg/m2. A total of 37 (36%) patients had MBD (osteomalacia in 31 and low bone mass in 6). The frequency of MBD was same in the TCP (16/35) and ACP (21/65) groups (P = 0.1940). Elevated PTH (>70 pg/mL) was seen in 14 patients with 25OHD deficiency and low calcium ( |
| doi_str_mv | 10.4103/njcp.njcp_42_17 |
| format | Article |
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We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP.
In this cross-sectional, observational study, we included serial patients of CP in different stages and are grouped as ACP (Group 1; n = 67) and TCP (Group 2; n = 35). We determined serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D (25OHD), and intact parathyroid hormone (PTH) levels. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry in the neck of the left femur. MBD was defined by the presence of either low bone mass (Z-score Results: The study participants (85 males; 17 females) had a mean age of 40.8 ± 12.6 years, CP duration of 3.7 ± 4.7 years, and Body Mass Index of 22.5 ± 3.2 kg/m2. A total of 37 (36%) patients had MBD (osteomalacia in 31 and low bone mass in 6). The frequency of MBD was same in the TCP (16/35) and ACP (21/65) groups (P = 0.1940). Elevated PTH (>70 pg/mL) was seen in 14 patients with 25OHD deficiency and low calcium (<8.5 mg/dL) in 29 patients. BMD did not show a significant correlation with the duration of CP.
Occult MBD is seen in a third of patients with CP and is similar irrespective of the etiology. The disease is silent and mandates active screening in all susceptible individuals.</description><identifier>ISSN: 1119-3077</identifier><identifier>DOI: 10.4103/njcp.njcp_42_17</identifier><identifier>PMID: 29072234</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Absorptiometry, Photon ; Adult ; Alkaline Phosphatase - blood ; Body Mass Index ; Bone Density ; Bone diseases ; Bone Diseases, Metabolic - blood ; Bone Diseases, Metabolic - diagnosis ; Bone Diseases, Metabolic - epidemiology ; Calcium - blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Osteomalacia - epidemiology ; Pancreatitis ; Pancreatitis, Chronic - blood ; Pancreatitis, Chronic - diagnosis ; Pancreatitis, Chronic - epidemiology ; Parathyroid Hormone - blood ; Risk factors ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Nigerian journal of clinical practice, 2017-09, Vol.20 (9), p.1122-1126</ispartof><rights>COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-dc287d11eeec21b535b51cb726075d67314989e7aff6504b54059c916f327f8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29072234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Kvs Hari</creatorcontrib><creatorcontrib>Sood, A K</creatorcontrib><creatorcontrib>Manrai, M</creatorcontrib><title>Occult metabolic bone disease in chronic pancreatitis</title><title>Nigerian journal of clinical practice</title><addtitle>Niger J Clin Pract</addtitle><description>Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP.
We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP.
In this cross-sectional, observational study, we included serial patients of CP in different stages and are grouped as ACP (Group 1; n = 67) and TCP (Group 2; n = 35). We determined serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D (25OHD), and intact parathyroid hormone (PTH) levels. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry in the neck of the left femur. MBD was defined by the presence of either low bone mass (Z-score Results: The study participants (85 males; 17 females) had a mean age of 40.8 ± 12.6 years, CP duration of 3.7 ± 4.7 years, and Body Mass Index of 22.5 ± 3.2 kg/m2. A total of 37 (36%) patients had MBD (osteomalacia in 31 and low bone mass in 6). The frequency of MBD was same in the TCP (16/35) and ACP (21/65) groups (P = 0.1940). Elevated PTH (>70 pg/mL) was seen in 14 patients with 25OHD deficiency and low calcium (<8.5 mg/dL) in 29 patients. BMD did not show a significant correlation with the duration of CP.
Occult MBD is seen in a third of patients with CP and is similar irrespective of the etiology. The disease is silent and mandates active screening in all susceptible individuals.</description><subject>Absorptiometry, Photon</subject><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Body Mass Index</subject><subject>Bone Density</subject><subject>Bone diseases</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Bone Diseases, Metabolic - diagnosis</subject><subject>Bone Diseases, Metabolic - epidemiology</subject><subject>Calcium - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteomalacia - epidemiology</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Chronic - blood</subject><subject>Pancreatitis, Chronic - diagnosis</subject><subject>Pancreatitis, Chronic - epidemiology</subject><subject>Parathyroid Hormone - blood</subject><subject>Risk factors</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>1119-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtrwzAQhHVoadK0596KoVB6caK1LMs6htAXBHJpz0KW142CbaWWfOi_r9Okj0BZ2IXhm4VhCLkCOk2Bslm7Mdvpbqk0USBOyBgAZMyoECNy7v2G0kyyHM7IKJFUJAlLx4SvjOnrEDUYdOFqa6LCtRiV1qP2GNk2MuvOtYO-1a3pUAcbrL8gp5WuPV4e7oS8Pty_LJ7i5erxeTFfxoZJHuLSJLkoARDRJFBwxgsOphBJRgUvM8EglblEoasq4zQteEq5NBKyiiWiypFNyN3-77Zz7z36oBrrDda1btH1XoHkw6ucUzmgN3v0TdeobFu50Gmzw9WcA2SQ8zwfqOk_1DAlNtYMySs76EeG2z-GNeo6rL2r-2Bd64_B2R40nfO-w0ptO9vo7kMBVbt-1Fc1v_0MjutDuL5osPzhv8thn84_jJA</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Kumar, Kvs Hari</creator><creator>Sood, A K</creator><creator>Manrai, M</creator><general>Medknow Publications and Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Occult metabolic bone disease in chronic pancreatitis</title><author>Kumar, Kvs Hari ; Sood, A K ; Manrai, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-dc287d11eeec21b535b51cb726075d67314989e7aff6504b54059c916f327f8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorptiometry, Photon</topic><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Body Mass Index</topic><topic>Bone Density</topic><topic>Bone diseases</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Bone Diseases, Metabolic - diagnosis</topic><topic>Bone Diseases, Metabolic - epidemiology</topic><topic>Calcium - blood</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteomalacia - epidemiology</topic><topic>Pancreatitis</topic><topic>Pancreatitis, Chronic - blood</topic><topic>Pancreatitis, Chronic - diagnosis</topic><topic>Pancreatitis, Chronic - epidemiology</topic><topic>Parathyroid Hormone - blood</topic><topic>Risk factors</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Kvs Hari</creatorcontrib><creatorcontrib>Sood, A K</creatorcontrib><creatorcontrib>Manrai, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nigerian journal of clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Kvs Hari</au><au>Sood, A K</au><au>Manrai, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occult metabolic bone disease in chronic pancreatitis</atitle><jtitle>Nigerian journal of clinical practice</jtitle><addtitle>Niger J Clin Pract</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>20</volume><issue>9</issue><spage>1122</spage><epage>1126</epage><pages>1122-1126</pages><issn>1119-3077</issn><abstract>Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP.
We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP.
In this cross-sectional, observational study, we included serial patients of CP in different stages and are grouped as ACP (Group 1; n = 67) and TCP (Group 2; n = 35). We determined serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D (25OHD), and intact parathyroid hormone (PTH) levels. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry in the neck of the left femur. MBD was defined by the presence of either low bone mass (Z-score Results: The study participants (85 males; 17 females) had a mean age of 40.8 ± 12.6 years, CP duration of 3.7 ± 4.7 years, and Body Mass Index of 22.5 ± 3.2 kg/m2. A total of 37 (36%) patients had MBD (osteomalacia in 31 and low bone mass in 6). The frequency of MBD was same in the TCP (16/35) and ACP (21/65) groups (P = 0.1940). Elevated PTH (>70 pg/mL) was seen in 14 patients with 25OHD deficiency and low calcium (<8.5 mg/dL) in 29 patients. BMD did not show a significant correlation with the duration of CP.
Occult MBD is seen in a third of patients with CP and is similar irrespective of the etiology. The disease is silent and mandates active screening in all susceptible individuals.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>29072234</pmid><doi>10.4103/njcp.njcp_42_17</doi><tpages>5</tpages></addata></record> |
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| source | African Journals Online (Open Access); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Absorptiometry, Photon Adult Alkaline Phosphatase - blood Body Mass Index Bone Density Bone diseases Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - diagnosis Bone Diseases, Metabolic - epidemiology Calcium - blood Cross-Sectional Studies Female Humans Male Middle Aged Osteomalacia - epidemiology Pancreatitis Pancreatitis, Chronic - blood Pancreatitis, Chronic - diagnosis Pancreatitis, Chronic - epidemiology Parathyroid Hormone - blood Risk factors Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Occult metabolic bone disease in chronic pancreatitis |
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