A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss

Both the antioxidant, n-l-acetyl cysteine (L-NAC) and the Src inhibitor, KX1-004, have been used to protect the cochlea from hazardous noise. To date, KX1-004 has only been used locally on the round window. In the current study, the two drugs were administered systemically. LNAC was delivered intrap...

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Veröffentlicht in:	Noise & health 2005-10, Vol.7 (29), p.24-30
Hauptverfasser:	Bielefeld, Eric C, Hynes, Sarah, Pryznosch, David, Liu, Jianzhong, Coleman, John Km, Henderson, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Acetylcysteine - pharmacology Animals Antioxidants Apoptosis Apoptosis - drug effects Auditory Threshold - drug effects Chinchilla Deafness, Noise induced Disease Models, Animal Dosage and administration Drug dosages Drug therapy Electrodes Environmental Exposure - adverse effects Evoked Potentials, Auditory - drug effects Free radicals Glutathione - administration & dosage Glutathione - pharmacology Hearing loss Hearing Loss, Noise-Induced - drug therapy Hearing Loss, Noise-Induced - prevention & control Hearing protection Inferior Colliculi - physiology Injections, Intraperitoneal Kinases Noise Noise - adverse effects Pharmaceutical research Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Reactive Oxygen Species - adverse effects Side effects src-Family Kinases - administration & dosage src-Family Kinases - antagonists & inhibitors src-Family Kinases - pharmacology Studies Time Factors
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