Scopoletin‐standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study

The effect of scopoletin‐standardized Morinda elliptica leaf extract against osteoarthritis was investigated in ex vivo explant culture and preclinical rodent model. Thirty male rats were grouped (n = 6) into untreated osteoarthritis (OA), OA + Diclofenac (5 mg/kg), and OA + extract (200 and 400 mg/...

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Veröffentlicht in:	Phytotherapy research 2017-12, Vol.31 (12), p.1954-1961
Hauptverfasser:	Wan Osman, Wan Nurfarahin, Lau, Seng Fong, Mohamed, Suhaila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis articular cartilage Biocompatibility Biomarkers Bone growth Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Chondrocytes Collagen Collagenase Computed tomography Degradation Diclofenac Disease Models, Animal Enzyme-linked immunosorbent assay Female Gene expression Homeostasis Humans Inflammation Inflammation - metabolism Interleukin 1 Joint diseases Knee Leaves Male MIA (monosodium iodoacetate) Middle Aged Morinda Morinda - chemistry Morinda Elliptica Nitric oxide Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - pathology Osteogenesis rat Rats Rodents Scopoletin - chemistry Subchondral bone
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