Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats

Berberine, a well‐known plant alkaloid derived from Rhizoma coptidis, has potential applications as a therapeutic drug for diabetic nephropathy. However, the transporter‐mediated renal transport of berberine remains largely unclear. This study aimed to investigate the renal transport mechanism of be...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2018-01, Vol.39 (1), p.47-58
Hauptverfasser:	Shi, Rong, Yang, Yuanyuan, Xu, Zhangyao, Dai, Yan, Zheng, Min, Wang, Tianming, Li, Yuanyuan, Ma, Yueming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal research Animals Antiporters - metabolism Berberine Berberine - pharmacokinetics Berberine - urine Biological Transport - drug effects Cells, Cultured Corticosterone Corticosterone - pharmacology Diabetes mellitus Diabetic nephropathy Dogs Drug Interactions Excretion Kidney - drug effects Kidney - metabolism Male MATE1 MDR1 protein Nephropathy Oct-2 protein OCT2 Organic Cation Transport Proteins - metabolism Organic cation transporter Organic Cation Transporter 2 - metabolism P-Glycoprotein pharmacokinetics Proteins Pyrimethamine Pyrimethamine - pharmacology Rats renal transport Rodents
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