Z-505 hydrochloride ameliorates chemotherapy-induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a

Despite its therapeutic advantages, chemotherapy with anti-cancer drugs can cause adverse effects, including anorexia and weight loss. Although most patients with cancer suffer from anorexia during chemotherapy, resulting in the need to suspend or cease treatment and thereby worsening prognosis, tre...

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Veröffentlicht in:	European journal of pharmacology 2018-01, Vol.818, p.148-157
Hauptverfasser:	Shiomi, Yoshihiro, Ohira, Yuta, Yoshimura, Makoto, Ozaki, Tomoko, Takei, Mineo, Tanaka, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Amides - therapeutic use Animals Anorexia Anorexia - chemically induced Anorexia - drug therapy Anorexia - metabolism Anorexia - physiopathology Antineoplastic Agents - adverse effects Body Weight - drug effects Chemotherapy CHO Cells Cisplatin - adverse effects Cricetinae Cricetulus Eating - drug effects Fluorouracil - adverse effects Ghrelin GHSR1a Mice Pyrrolidines - pharmacology Pyrrolidines - therapeutic use Rats Receptors, Ghrelin - metabolism Z-505
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