Pediatric traumatic brain injury at Mbarara Regional Referral Hospital, Uganda
•The majority of TBIs in Uganda affect children aged 2–5 years and 12–18 years.•Children
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| Veröffentlicht in: | Journal of clinical neuroscience 2018-01, Vol.47, p.79-83 |
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| container_title | Journal of clinical neuroscience |
| container_volume | 47 |
| creator | Abdelgadir, Jihad Punchak, Maria Smith, Emily R. Tarnasky, Aaron Muhindo, Alex Nickenig Vissoci, Joao Ricardo Haglund, Michael M. Kitya, David |
| description | •The majority of TBIs in Uganda affect children aged 2–5 years and 12–18 years.•Children |
| doi_str_mv | 10.1016/j.jocn.2017.10.004 |
| format | Article |
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In Uganda, TBI constitute the majority of neurosurgical admissions and deaths specially in the pediatric population. This study aims to determine the factors associated with poor outcome among pediatric TBI cases at a major referral hospital in western Uganda.
This study was conducted at Mbarara Regional Referral Hospital (MRRH) in western Uganda. All pediatric neurosurgical cases between 2012 and 2015 were reviewed. In-hospital mortality and discharge GCS were the main outcomes of interest. Multivariable logistic regression with backward elimination was used to determine the factors significantly associated with outcome.
A total of 381 pediatric TBI patients were admitted to MRRH between 2012 and 2015. The mean age was 8.6 (SD 5.6) with a male predominance (62.0%). The most common mechanism of injury overall was RTI, which was responsible for 71% of all TBI cases. In the multivariable logistic regression model, admission GCS < 13 was a strong predictor of poor outcome and in-hospital mortality compared to admission GCS ≥ 13, with patients demonstrating an odds ratio of 30 (95%CI: 7-132) and OR of 18 (95%CI: 4-79), respectively.
Given the lack of published literature on pediatric TBI in LMICs, this study was the first to describe and evaluate risk factors associated with TBI severity among pediatric patients at a major referral hospital in western Uganda. Injury severity on admission was the only variable found to be significantly associated with discharge outcome. This study ultimately highlights the need for more effective preventative measures to decrease admission severity.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2017.10.004</identifier><identifier>PMID: 29066002</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><ispartof>Journal of clinical neuroscience, 2018-01, Vol.47, p.79-83</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d963df24daaed0905607ad7f28238b8b441fc70599af76a6415b4994ec759c6c3</citedby><cites>FETCH-LOGICAL-c356t-d963df24daaed0905607ad7f28238b8b441fc70599af76a6415b4994ec759c6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2017.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29066002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdelgadir, Jihad</creatorcontrib><creatorcontrib>Punchak, Maria</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Tarnasky, Aaron</creatorcontrib><creatorcontrib>Muhindo, Alex</creatorcontrib><creatorcontrib>Nickenig Vissoci, Joao Ricardo</creatorcontrib><creatorcontrib>Haglund, Michael M.</creatorcontrib><creatorcontrib>Kitya, David</creatorcontrib><title>Pediatric traumatic brain injury at Mbarara Regional Referral Hospital, Uganda</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>•The majority of TBIs in Uganda affect children aged 2–5 years and 12–18 years.•Children <2 are more likely to have a moderate/severe discharge GCS.•Admission GCS was the only variable associated with discharge outcome.•There is a need for more effective measures to prevent pediatric head trauma.
In Uganda, TBI constitute the majority of neurosurgical admissions and deaths specially in the pediatric population. This study aims to determine the factors associated with poor outcome among pediatric TBI cases at a major referral hospital in western Uganda.
This study was conducted at Mbarara Regional Referral Hospital (MRRH) in western Uganda. All pediatric neurosurgical cases between 2012 and 2015 were reviewed. In-hospital mortality and discharge GCS were the main outcomes of interest. Multivariable logistic regression with backward elimination was used to determine the factors significantly associated with outcome.
A total of 381 pediatric TBI patients were admitted to MRRH between 2012 and 2015. The mean age was 8.6 (SD 5.6) with a male predominance (62.0%). The most common mechanism of injury overall was RTI, which was responsible for 71% of all TBI cases. In the multivariable logistic regression model, admission GCS < 13 was a strong predictor of poor outcome and in-hospital mortality compared to admission GCS ≥ 13, with patients demonstrating an odds ratio of 30 (95%CI: 7-132) and OR of 18 (95%CI: 4-79), respectively.
Given the lack of published literature on pediatric TBI in LMICs, this study was the first to describe and evaluate risk factors associated with TBI severity among pediatric patients at a major referral hospital in western Uganda. Injury severity on admission was the only variable found to be significantly associated with discharge outcome. This study ultimately highlights the need for more effective preventative measures to decrease admission severity.</description><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMoOj7-gAvp0oUdb9IkbcCNDL7AF6LrcJukktJpx6QV_PdmGHUpd3EPh3MP3I-QYwpzClSet_N2MP2cAS2TMQfgW2RGRcFyJkWxTWagZJmLSlZ7ZD_GFgAUL2CX7DEFUgKwGXl8dtbjGLzJxoDTEsek6oC-z3zfTuErwzF7qDGkyV7cux967JJoXAhJ3A5x5UfszrK3d-wtHpKdBrvojn72AXm7vnpd3Ob3Tzd3i8v73BRCjrlVsrAN4xbRWVAgJJRoy4ZVrKjqquacNqYEoRQ2pUTJqai5UtyZUigjTXFATje9qzB8TC6OeumjcV2HvRumqKkSQqiKM5GibBM1YYgxuEavgl9i-NIU9JqjbvWao15zXHuJYzo6-emf6qWzfye_4FLgYhNw6ctP74KOxrveJJrBmVHbwf_X_w3T8YNu</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Abdelgadir, Jihad</creator><creator>Punchak, Maria</creator><creator>Smith, Emily R.</creator><creator>Tarnasky, Aaron</creator><creator>Muhindo, Alex</creator><creator>Nickenig Vissoci, Joao Ricardo</creator><creator>Haglund, Michael M.</creator><creator>Kitya, David</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Pediatric traumatic brain injury at Mbarara Regional Referral Hospital, Uganda</title><author>Abdelgadir, Jihad ; Punchak, Maria ; Smith, Emily R. ; Tarnasky, Aaron ; Muhindo, Alex ; Nickenig Vissoci, Joao Ricardo ; Haglund, Michael M. ; Kitya, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d963df24daaed0905607ad7f28238b8b441fc70599af76a6415b4994ec759c6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelgadir, Jihad</creatorcontrib><creatorcontrib>Punchak, Maria</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Tarnasky, Aaron</creatorcontrib><creatorcontrib>Muhindo, Alex</creatorcontrib><creatorcontrib>Nickenig Vissoci, Joao Ricardo</creatorcontrib><creatorcontrib>Haglund, Michael M.</creatorcontrib><creatorcontrib>Kitya, David</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelgadir, Jihad</au><au>Punchak, Maria</au><au>Smith, Emily R.</au><au>Tarnasky, Aaron</au><au>Muhindo, Alex</au><au>Nickenig Vissoci, Joao Ricardo</au><au>Haglund, Michael M.</au><au>Kitya, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric traumatic brain injury at Mbarara Regional Referral Hospital, Uganda</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2018-01</date><risdate>2018</risdate><volume>47</volume><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>•The majority of TBIs in Uganda affect children aged 2–5 years and 12–18 years.•Children <2 are more likely to have a moderate/severe discharge GCS.•Admission GCS was the only variable associated with discharge outcome.•There is a need for more effective measures to prevent pediatric head trauma.
In Uganda, TBI constitute the majority of neurosurgical admissions and deaths specially in the pediatric population. This study aims to determine the factors associated with poor outcome among pediatric TBI cases at a major referral hospital in western Uganda.
This study was conducted at Mbarara Regional Referral Hospital (MRRH) in western Uganda. All pediatric neurosurgical cases between 2012 and 2015 were reviewed. In-hospital mortality and discharge GCS were the main outcomes of interest. Multivariable logistic regression with backward elimination was used to determine the factors significantly associated with outcome.
A total of 381 pediatric TBI patients were admitted to MRRH between 2012 and 2015. The mean age was 8.6 (SD 5.6) with a male predominance (62.0%). The most common mechanism of injury overall was RTI, which was responsible for 71% of all TBI cases. In the multivariable logistic regression model, admission GCS < 13 was a strong predictor of poor outcome and in-hospital mortality compared to admission GCS ≥ 13, with patients demonstrating an odds ratio of 30 (95%CI: 7-132) and OR of 18 (95%CI: 4-79), respectively.
Given the lack of published literature on pediatric TBI in LMICs, this study was the first to describe and evaluate risk factors associated with TBI severity among pediatric patients at a major referral hospital in western Uganda. Injury severity on admission was the only variable found to be significantly associated with discharge outcome. This study ultimately highlights the need for more effective preventative measures to decrease admission severity.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>29066002</pmid><doi>10.1016/j.jocn.2017.10.004</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| title | Pediatric traumatic brain injury at Mbarara Regional Referral Hospital, Uganda |
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