CpG methylation patterns in the IFNγ promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non-atopics

Interferon‐γ (IFNγ) gene expression is tightly regulated in early life, and exaggerated negative control of IFNγ production in CD4+ T cells has been associated with risk for subsequent development of atopy. Recent studies have demonstrated hypermethylation of CpG sites in the IFNγ promoter in neonat...

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Veröffentlicht in:	Pediatric allergy and immunology 2006-12, Vol.17 (8), p.557-564
Hauptverfasser:	White, Gregory P., Hollams, Elysia M., Yerkovich, Stephanie T., Bosco, Anthony, Holt, Barbara J., Bassami, Mohammad R., Kusel, Merci, Sly, Peter D., Holt, Patrick G.
Format:	Artikel
Sprache:	eng
Schlagworte:	atopy CpG helper T cell IFNγ methylation
Online-Zugang:	Volltext
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