Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots
We studied the influence of lipid surface composition on the kinetics of fibrin clot formation and its structure. It was shown that lipid surface affects all phases of fibrin polymerization and chances clot morphology. The magnitude and character of the effect depend on the charge and phase state of...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-10, Vol.163 (6), p.722-725 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Bakirova, D. R. Faizullin, D. A. Valiullina, Yu. A. Salnikov, V. V. Zuev, Yu. F. |
| description | We studied the influence of lipid surface composition on the kinetics of fibrin clot formation and its structure. It was shown that lipid surface affects all phases of fibrin polymerization and chances clot morphology. The magnitude and character of the effect depend on the charge and phase state of lipids that determine the interaction of fibrinogen with the lipid surface and its conformational changes, which modulated the process of fibrinogen conversion into fibrin and, as a result, the formation and morphology of the fibrin clot. |
| doi_str_mv | 10.1007/s10517-017-3889-5 |
| format | Article |
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F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>163</volume><issue>6</issue><spage>722</spage><epage>725</epage><pages>722-725</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied the influence of lipid surface composition on the kinetics of fibrin clot formation and its structure. It was shown that lipid surface affects all phases of fibrin polymerization and chances clot morphology. The magnitude and character of the effect depend on the charge and phase state of lipids that determine the interaction of fibrinogen with the lipid surface and its conformational changes, which modulated the process of fibrinogen conversion into fibrin and, as a result, the formation and morphology of the fibrin clot.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29063338</pmid><doi>10.1007/s10517-017-3889-5</doi><tpages>4</tpages></addata></record> |
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| subjects | 1,2-Dipalmitoylphosphatidylcholine - chemistry Adsorption Animals Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Cattle Cell Biology Fibrin Fibrin - chemistry Fibrin - ultrastructure Fibrinogen - chemistry Internal Medicine Kinetics Laboratory Medicine Lipids Liposomes - chemistry Nephelometry and Turbidimetry Pathology Phosphatidylcholines - chemistry Phosphatidylglycerols - chemistry Polymerization Solutions Thrombin - chemistry Thrombosis |
| title | Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots |
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