Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect
We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and opti...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-10, Vol.163 (6), p.753-756 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kulikovskii, V. F. Zhilyakova, E. T. Novikov, O. O. Pisarev, D. I. Prokushchenko, N. V. Ivanova, L. L. |
| description | We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant fragmentation are determined. Chemical composition of the sedative tea is evaluated by reverse phase HPLC. The marker components of the species are detected: xanthohumol and isoxanthohumol —
Humulus lupulus
cone components,
Mentha piperita
rosmarinic acid, and scutellareine,
Menyanthes trifolia
element — quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested. |
| doi_str_mv | 10.1007/s10517-017-3896-6 |
| format | Article |
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Humulus lupulus
cone components,
Mentha piperita
rosmarinic acid, and scutellareine,
Menyanthes trifolia
element — quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3896-6</identifier><identifier>PMID: 29063320</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject><![CDATA[Apigenin - chemistry ; Apigenin - isolation & purification ; Biomedical and Life Sciences ; Biomedicine ; Caffeic Acids - chemistry ; Caffeic Acids - isolation & purification ; Cell Biology ; Chromatography, High Pressure Liquid ; Cinnamates - chemistry ; Cinnamates - isolation & purification ; Depsides - chemistry ; Depsides - isolation & purification ; Ethanol - chemistry ; Flavonoids - chemistry ; Flavonoids - isolation & purification ; Health aspects ; Herbal medicine ; High performance liquid chromatography ; Histamine H1 Antagonists - chemistry ; Histamine H1 Antagonists - isolation & purification ; Histamine H1 Antagonists - standards ; Humans ; Humulus - chemistry ; Internal Medicine ; Laboratory Medicine ; Loratadine ; Medicinal plants ; Mentha piperita - chemistry ; Pathology ; Phytochemicals - chemistry ; Phytochemicals - isolation & purification ; Phytochemicals - standards ; Plant Extracts - chemistry ; Propiophenones - chemistry ; Propiophenones - isolation & purification ; Rosmarinic Acid ; Rutin ; Rutin - chemistry ; Rutin - isolation & purification ; Solvents - chemistry ; Suppositories - chemical synthesis ; Xanthones - chemistry ; Xanthones - isolation & purification]]></subject><ispartof>Bulletin of experimental biology and medicine, 2017-10, Vol.163 (6), p.753-756</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>COPYRIGHT 2017 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-85e6b818388575dda14abc9a0d7e20b110e9cddf4a77a2ed52272a4fac66624a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3896-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3896-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29063320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulikovskii, V. F.</creatorcontrib><creatorcontrib>Zhilyakova, E. T.</creatorcontrib><creatorcontrib>Novikov, O. O.</creatorcontrib><creatorcontrib>Pisarev, D. I.</creatorcontrib><creatorcontrib>Prokushchenko, N. V.</creatorcontrib><creatorcontrib>Ivanova, L. L.</creatorcontrib><title>Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant fragmentation are determined. Chemical composition of the sedative tea is evaluated by reverse phase HPLC. The marker components of the species are detected: xanthohumol and isoxanthohumol —
Humulus lupulus
cone components,
Mentha piperita
rosmarinic acid, and scutellareine,
Menyanthes trifolia
element — quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested.</description><subject>Apigenin - chemistry</subject><subject>Apigenin - isolation & purification</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Caffeic Acids - chemistry</subject><subject>Caffeic Acids - isolation & purification</subject><subject>Cell Biology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cinnamates - chemistry</subject><subject>Cinnamates - isolation & purification</subject><subject>Depsides - chemistry</subject><subject>Depsides - isolation & purification</subject><subject>Ethanol - chemistry</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - isolation & purification</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>High performance liquid chromatography</subject><subject>Histamine H1 Antagonists - chemistry</subject><subject>Histamine H1 Antagonists - isolation & purification</subject><subject>Histamine H1 Antagonists - standards</subject><subject>Humans</subject><subject>Humulus - chemistry</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Loratadine</subject><subject>Medicinal plants</subject><subject>Mentha piperita - chemistry</subject><subject>Pathology</subject><subject>Phytochemicals - chemistry</subject><subject>Phytochemicals - isolation & purification</subject><subject>Phytochemicals - standards</subject><subject>Plant Extracts - chemistry</subject><subject>Propiophenones - chemistry</subject><subject>Propiophenones - isolation & purification</subject><subject>Rosmarinic Acid</subject><subject>Rutin</subject><subject>Rutin - chemistry</subject><subject>Rutin - isolation & purification</subject><subject>Solvents - chemistry</subject><subject>Suppositories - chemical synthesis</subject><subject>Xanthones - chemistry</subject><subject>Xanthones - isolation & purification</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFr1TAUx4so7m76AXyRgCB76UzSpkkfL9dNhYHi5nM4Nz29zWyba5I67yfwa5uuUxyIhBCS8_sdyPln2QtGzxil8k1gVDCZ07QLVVd59ShbMSGLXHHOHmcrmqC8VEodZcch3MxXWrGn2RGvaVUUnK6yn1dxag7EteQKG4j2O5JrBPKpO0Rn3LDv8Qe5tbGzI4kdkgsPA946__XOSKrFQNZ2wIZAJBuPqYUb5yKQz2gi9OStC7BLpvPDXSeyHqPtbIgw2NEact62CXyWPWmhD_j8_jzJvlycX2_e55cf333YrC9zUxYy5kpgtVVMFUoJKZoGWAlbUwNtJHK6ZYxibZqmLUFK4NgIziWHsgVTVRUvoTjJTpe-e---TRiiHmww2PcwopuCZrUQVPKai4S-WtAd9Kjt2Lrowcy4XgsmhKK8kok6-weVVoODNW7E1qb3B8Lrv4QOoY9dcP00Dy48BNkCGu9C8NjqvbcD-INmVM_56yV_nfLXc_66Ss7L--9N2xTKH-N34AngCxBSadyh1zdu8mMa-X-6_gIEF7mt</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Kulikovskii, V. F.</creator><creator>Zhilyakova, E. T.</creator><creator>Novikov, O. O.</creator><creator>Pisarev, D. I.</creator><creator>Prokushchenko, N. V.</creator><creator>Ivanova, L. L.</creator><general>Springer US</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect</title><author>Kulikovskii, V. F. ; Zhilyakova, E. T. ; Novikov, O. O. ; Pisarev, D. I. ; Prokushchenko, N. V. ; Ivanova, L. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-85e6b818388575dda14abc9a0d7e20b110e9cddf4a77a2ed52272a4fac66624a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apigenin - chemistry</topic><topic>Apigenin - isolation & purification</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Caffeic Acids - chemistry</topic><topic>Caffeic Acids - isolation & purification</topic><topic>Cell Biology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cinnamates - chemistry</topic><topic>Cinnamates - isolation & purification</topic><topic>Depsides - chemistry</topic><topic>Depsides - isolation & purification</topic><topic>Ethanol - chemistry</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - isolation & purification</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>High performance liquid chromatography</topic><topic>Histamine H1 Antagonists - chemistry</topic><topic>Histamine H1 Antagonists - isolation & purification</topic><topic>Histamine H1 Antagonists - standards</topic><topic>Humans</topic><topic>Humulus - chemistry</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Loratadine</topic><topic>Medicinal plants</topic><topic>Mentha piperita - chemistry</topic><topic>Pathology</topic><topic>Phytochemicals - chemistry</topic><topic>Phytochemicals - isolation & purification</topic><topic>Phytochemicals - standards</topic><topic>Plant Extracts - chemistry</topic><topic>Propiophenones - chemistry</topic><topic>Propiophenones - isolation & purification</topic><topic>Rosmarinic Acid</topic><topic>Rutin</topic><topic>Rutin - chemistry</topic><topic>Rutin - isolation & purification</topic><topic>Solvents - chemistry</topic><topic>Suppositories - chemical synthesis</topic><topic>Xanthones - chemistry</topic><topic>Xanthones - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulikovskii, V. F.</creatorcontrib><creatorcontrib>Zhilyakova, E. T.</creatorcontrib><creatorcontrib>Novikov, O. O.</creatorcontrib><creatorcontrib>Pisarev, D. I.</creatorcontrib><creatorcontrib>Prokushchenko, N. V.</creatorcontrib><creatorcontrib>Ivanova, L. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulikovskii, V. F.</au><au>Zhilyakova, E. T.</au><au>Novikov, O. O.</au><au>Pisarev, D. I.</au><au>Prokushchenko, N. V.</au><au>Ivanova, L. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>163</volume><issue>6</issue><spage>753</spage><epage>756</epage><pages>753-756</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant fragmentation are determined. Chemical composition of the sedative tea is evaluated by reverse phase HPLC. The marker components of the species are detected: xanthohumol and isoxanthohumol —
Humulus lupulus
cone components,
Mentha piperita
rosmarinic acid, and scutellareine,
Menyanthes trifolia
element — quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29063320</pmid><doi>10.1007/s10517-017-3896-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2017-10, Vol.163 (6), p.753-756 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Apigenin - chemistry Apigenin - isolation & purification Biomedical and Life Sciences Biomedicine Caffeic Acids - chemistry Caffeic Acids - isolation & purification Cell Biology Chromatography, High Pressure Liquid Cinnamates - chemistry Cinnamates - isolation & purification Depsides - chemistry Depsides - isolation & purification Ethanol - chemistry Flavonoids - chemistry Flavonoids - isolation & purification Health aspects Herbal medicine High performance liquid chromatography Histamine H1 Antagonists - chemistry Histamine H1 Antagonists - isolation & purification Histamine H1 Antagonists - standards Humans Humulus - chemistry Internal Medicine Laboratory Medicine Loratadine Medicinal plants Mentha piperita - chemistry Pathology Phytochemicals - chemistry Phytochemicals - isolation & purification Phytochemicals - standards Plant Extracts - chemistry Propiophenones - chemistry Propiophenones - isolation & purification Rosmarinic Acid Rutin Rutin - chemistry Rutin - isolation & purification Solvents - chemistry Suppositories - chemical synthesis Xanthones - chemistry Xanthones - isolation & purification |
| title | Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect |
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