Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

Background Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in...

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Veröffentlicht in:	Journal of gastroenterology 2018-05, Vol.53 (5), p.660-669
Hauptverfasser:	Yokoyama, Akira, Taniki, Nobuhito, Hara, Sachiko, Haysashi, Emiko, Nakamoto, Nobuhiro, Mizukami, Takeshi, Maruyama, Katsuya, Yokoyama, Tetsuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Acetaldehyde Adult Age Factors Aged Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol use Alcoholic beverages Alcoholism - complications Aldehyde dehydrogenase Aldehyde Dehydrogenase, Mitochondrial - genetics Biliary Tract Body fat Body Mass Index Body weight Care and treatment Cirrhosis Colorectal Surgery Dehydrogenases Drinking of alcoholic beverages Drug dependence Ethanol Fat metabolism Fatty liver Fatty Liver, Alcoholic - diagnostic imaging Fatty Liver, Alcoholic - etiology Fatty Liver, Alcoholic - genetics Gastroenterology Genotypes Hepatology Heterozygote Humans Japan Lipid metabolism Liver Liver cirrhosis Male Medicine Medicine & Public Health Metabolism Middle Aged Multivariate analysis Original Article—Liver Pancreas Physiological aspects Substance abuse Surgical Oncology Time Factors Ultrasonography Ultrasound Ultrasound imaging
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