Ca2+‐dependent down‐regulation of human histamine H1 receptors in Chinese hamster ovary cells

Gq/11 protein‐coupled human histamine H1 receptors in Chinese hamster ovary cells stimulated with histamine undergo clathrin‐dependent endocytosis followed by proteasome/lysosome‐mediated down‐regulation. In this study, we evaluated the effects of a sustained increase in intracellular Ca2+ concentra...

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Veröffentlicht in:	Journal of neurochemistry 2018-01, Vol.144 (1), p.68-80
Hauptverfasser:	Hishinuma, Shigeru, Komazaki, Hiroshi, Tsukamoto, Hayato, Hatahara, Hirokazu, Fukui, Hiroyuki, Shoji, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Ca2 Calcium (extracellular) Calcium (intracellular) Calcium-binding protein Calmodulin Calpain Caveolae Cell surface Chelerythrine Chloroquine Clathrin Cysteine proteinase Deprivation Down-regulation Endocytosis Histamine histamine H1 receptor Histamine H1 receptors Hydrophobicity Immunofluorescence Inhibitors internalization Intracellular Ionomycin Kinases Lactacystin Leupeptin Lipid rafts Lysosomes Microscopy Nystatin Proteasomes Pyrilamine Rafts Receptors Sucrose Sugar
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