Prospects of Contrast‐Enhanced Ultrasonography for the Diagnosis of Peripheral Arterial Disease: A Meta‐analysis
Objectives Contrast‐enhanced ultrasonography (CEUS) is a modern diagnostic method that can also be used to study microperfusion. This study compared the time to peak intensity measured by CEUS in patients with peripheral arterial disease (PAD) and healthy control participants. Methods After a compre...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2018-05, Vol.37 (5), p.1081-1090 |
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| creator | Hou, Xiao‐xia Chu, Guang‐hua Yu, Yuan |
| description | Objectives
Contrast‐enhanced ultrasonography (CEUS) is a modern diagnostic method that can also be used to study microperfusion. This study compared the time to peak intensity measured by CEUS in patients with peripheral arterial disease (PAD) and healthy control participants.
Methods
After a comprehensive literature search in multiple electronic databases and study selection, a random‐effect meta‐analysis was performed to compare the time to peak intensity measured by CEUS in patients with PAD and healthy controls, which followed meta‐regression analyses for identification of factors affecting the outcomes.
Results
Fourteen studies (data for 322 patients with PAD and 314 healthy individuals) were used for the meta‐analysis. The age of this sample of patients with PAD was 64.92 (95% confidence interval, 62.53, 67.31) years, and that of the healthy controls was 55.32 (51.67, 58.98) years. The times to peak intensity were 18.55 (15.62, 21.48) seconds in healthy controls, 33.40 (27.65, 39.15) seconds in patients with PAD, and 76.22 (36.23, 116.22) seconds in patients with PAD and diabetes mellitus. The difference between patients with PAD and healthy controls in the time to peak intensity was statistically significant (mean difference, 24.80 [10.16, 39.44] seconds; P |
| doi_str_mv | 10.1002/jum.14451 |
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Contrast‐enhanced ultrasonography (CEUS) is a modern diagnostic method that can also be used to study microperfusion. This study compared the time to peak intensity measured by CEUS in patients with peripheral arterial disease (PAD) and healthy control participants.
Methods
After a comprehensive literature search in multiple electronic databases and study selection, a random‐effect meta‐analysis was performed to compare the time to peak intensity measured by CEUS in patients with PAD and healthy controls, which followed meta‐regression analyses for identification of factors affecting the outcomes.
Results
Fourteen studies (data for 322 patients with PAD and 314 healthy individuals) were used for the meta‐analysis. The age of this sample of patients with PAD was 64.92 (95% confidence interval, 62.53, 67.31) years, and that of the healthy controls was 55.32 (51.67, 58.98) years. The times to peak intensity were 18.55 (15.62, 21.48) seconds in healthy controls, 33.40 (27.65, 39.15) seconds in patients with PAD, and 76.22 (36.23, 116.22) seconds in patients with PAD and diabetes mellitus. The difference between patients with PAD and healthy controls in the time to peak intensity was statistically significant (mean difference, 24.80 [10.16, 39.44] seconds; P < .00009). The ABI was not significantly associated with the time to peak intensity in patients with PAD. Age and sex were also not significantly associated with the time to peak intensity.
Conclusions
Contrast‐enhanced ultrasonography is a valuable tool for the diagnosis of PAD based on its ability to differentiate the time to peak intensity between patients with PAD and healthy individuals, but little data are yet available to assess its diagnostic ability in clinical practice.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.1002/jum.14451</identifier><identifier>PMID: 29064120</identifier><language>eng</language><publisher>England</publisher><subject>angiopathy ; atherosclerosis ; Contrast Media ; contrast‐enhanced ultrasonography ; diagnosis ; Humans ; Image Enhancement - methods ; peripheral arterial disease ; Peripheral Arterial Disease - diagnostic imaging ; peripheral vascular ; statistics ; therapeutic ; Ultrasonography - methods</subject><ispartof>Journal of ultrasound in medicine, 2018-05, Vol.37 (5), p.1081-1090</ispartof><rights>2017 by the American Institute of Ultrasound in Medicine</rights><rights>2017 by the American Institute of Ultrasound in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3911-ef2259d4ca7106b39d36b4dedeef347f0b03fb761435c19a47ca5dd493e71feb3</citedby><cites>FETCH-LOGICAL-c3911-ef2259d4ca7106b39d36b4dedeef347f0b03fb761435c19a47ca5dd493e71feb3</cites><orcidid>0000-0001-8082-5982</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjum.14451$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjum.14451$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29064120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Xiao‐xia</creatorcontrib><creatorcontrib>Chu, Guang‐hua</creatorcontrib><creatorcontrib>Yu, Yuan</creatorcontrib><title>Prospects of Contrast‐Enhanced Ultrasonography for the Diagnosis of Peripheral Arterial Disease: A Meta‐analysis</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>Objectives
Contrast‐enhanced ultrasonography (CEUS) is a modern diagnostic method that can also be used to study microperfusion. This study compared the time to peak intensity measured by CEUS in patients with peripheral arterial disease (PAD) and healthy control participants.
Methods
After a comprehensive literature search in multiple electronic databases and study selection, a random‐effect meta‐analysis was performed to compare the time to peak intensity measured by CEUS in patients with PAD and healthy controls, which followed meta‐regression analyses for identification of factors affecting the outcomes.
Results
Fourteen studies (data for 322 patients with PAD and 314 healthy individuals) were used for the meta‐analysis. The age of this sample of patients with PAD was 64.92 (95% confidence interval, 62.53, 67.31) years, and that of the healthy controls was 55.32 (51.67, 58.98) years. The times to peak intensity were 18.55 (15.62, 21.48) seconds in healthy controls, 33.40 (27.65, 39.15) seconds in patients with PAD, and 76.22 (36.23, 116.22) seconds in patients with PAD and diabetes mellitus. The difference between patients with PAD and healthy controls in the time to peak intensity was statistically significant (mean difference, 24.80 [10.16, 39.44] seconds; P < .00009). The ABI was not significantly associated with the time to peak intensity in patients with PAD. Age and sex were also not significantly associated with the time to peak intensity.
Conclusions
Contrast‐enhanced ultrasonography is a valuable tool for the diagnosis of PAD based on its ability to differentiate the time to peak intensity between patients with PAD and healthy individuals, but little data are yet available to assess its diagnostic ability in clinical practice.</description><subject>angiopathy</subject><subject>atherosclerosis</subject><subject>Contrast Media</subject><subject>contrast‐enhanced ultrasonography</subject><subject>diagnosis</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>peripheral arterial disease</subject><subject>Peripheral Arterial Disease - diagnostic imaging</subject><subject>peripheral vascular</subject><subject>statistics</subject><subject>therapeutic</subject><subject>Ultrasonography - methods</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUQC0EgvIY-AHkEYYU39iJMVvVlpeKYKBz5CTXNCiNg50KdeMT-Ea-BPcBG9P1tc49wyHkFFgfGIsv3xbzPgiRwA7pQZKwSKXAd0mPxfIqErGSB-TQ-7eAMpBinxzEiqUCYtYj3bOzvsWi89QaOrRN57Tvvj-_xs1MNwWWdFqvvmxjX51uZ0tqrKPdDOmo0q-N9dX68Bld1c7Q6ZoOXBeW8BhVHrXHazqgj9jp4NSNrpfh4pjsGV17PNnOIzK9Gb8M76LJ0-39cDCJCq4AIjRxnKhSFFoCS3OuSp7mosQS0XAhDcsZN7lMQfCkAKWFLHRSlkJxlGAw50fkfONtnX1foO-yeeULrGvdoF34DFSIlcorgIBebNAi9PAOTda6aq7dMgOWrSJnIXK2jhzYs612kc-x_CN_qwbgcgN8VDUu_zdlD9PHjfIHt0mJ6A</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Hou, Xiao‐xia</creator><creator>Chu, Guang‐hua</creator><creator>Yu, Yuan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8082-5982</orcidid></search><sort><creationdate>201805</creationdate><title>Prospects of Contrast‐Enhanced Ultrasonography for the Diagnosis of Peripheral Arterial Disease: A Meta‐analysis</title><author>Hou, Xiao‐xia ; Chu, Guang‐hua ; Yu, Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3911-ef2259d4ca7106b39d36b4dedeef347f0b03fb761435c19a47ca5dd493e71feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>angiopathy</topic><topic>atherosclerosis</topic><topic>Contrast Media</topic><topic>contrast‐enhanced ultrasonography</topic><topic>diagnosis</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>peripheral arterial disease</topic><topic>Peripheral Arterial Disease - diagnostic imaging</topic><topic>peripheral vascular</topic><topic>statistics</topic><topic>therapeutic</topic><topic>Ultrasonography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Xiao‐xia</creatorcontrib><creatorcontrib>Chu, Guang‐hua</creatorcontrib><creatorcontrib>Yu, Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Xiao‐xia</au><au>Chu, Guang‐hua</au><au>Yu, Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospects of Contrast‐Enhanced Ultrasonography for the Diagnosis of Peripheral Arterial Disease: A Meta‐analysis</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2018-05</date><risdate>2018</risdate><volume>37</volume><issue>5</issue><spage>1081</spage><epage>1090</epage><pages>1081-1090</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><abstract>Objectives
Contrast‐enhanced ultrasonography (CEUS) is a modern diagnostic method that can also be used to study microperfusion. This study compared the time to peak intensity measured by CEUS in patients with peripheral arterial disease (PAD) and healthy control participants.
Methods
After a comprehensive literature search in multiple electronic databases and study selection, a random‐effect meta‐analysis was performed to compare the time to peak intensity measured by CEUS in patients with PAD and healthy controls, which followed meta‐regression analyses for identification of factors affecting the outcomes.
Results
Fourteen studies (data for 322 patients with PAD and 314 healthy individuals) were used for the meta‐analysis. The age of this sample of patients with PAD was 64.92 (95% confidence interval, 62.53, 67.31) years, and that of the healthy controls was 55.32 (51.67, 58.98) years. The times to peak intensity were 18.55 (15.62, 21.48) seconds in healthy controls, 33.40 (27.65, 39.15) seconds in patients with PAD, and 76.22 (36.23, 116.22) seconds in patients with PAD and diabetes mellitus. The difference between patients with PAD and healthy controls in the time to peak intensity was statistically significant (mean difference, 24.80 [10.16, 39.44] seconds; P < .00009). The ABI was not significantly associated with the time to peak intensity in patients with PAD. Age and sex were also not significantly associated with the time to peak intensity.
Conclusions
Contrast‐enhanced ultrasonography is a valuable tool for the diagnosis of PAD based on its ability to differentiate the time to peak intensity between patients with PAD and healthy individuals, but little data are yet available to assess its diagnostic ability in clinical practice.</abstract><cop>England</cop><pmid>29064120</pmid><doi>10.1002/jum.14451</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8082-5982</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | angiopathy atherosclerosis Contrast Media contrast‐enhanced ultrasonography diagnosis Humans Image Enhancement - methods peripheral arterial disease Peripheral Arterial Disease - diagnostic imaging peripheral vascular statistics therapeutic Ultrasonography - methods |
| title | Prospects of Contrast‐Enhanced Ultrasonography for the Diagnosis of Peripheral Arterial Disease: A Meta‐analysis |
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