Endogenous pleiotrophin and midkine regulate LPS-induced glial responses

•LPS-induced glial responses were tested in PTN-/- and MK-/- mice.•Endogenous expression of PTN and MK in vivo is required for LPS-induced astrogliosis.•The data suggest that PTN and MK may modulate LPS-induced microglial activation.•Regulation of glial responses to LPS depends on the expression lev...

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Veröffentlicht in:	Neuroscience letters 2018-01, Vol.662, p.213-218
Hauptverfasser:	Fernández-Calle, Rosalía, Vicente-Rodríguez, Marta, Gramage, Esther, de la Torre-Ortiz, Carlos, Pérez-García, Carmen, Ramos, María P., Herradón, Gonzalo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Astrogliosis Carrier Proteins - metabolism Cell Line Corpus Striatum - drug effects Corpus Striatum - metabolism Cytokines - metabolism Encephalitis - chemically induced Encephalitis - metabolism FYN kinase Intercellular Signaling Peptides and Proteins - metabolism Lipopolysaccharides - administration & dosage Male Mice, Inbred C57BL Mice, Knockout Microglia Microglia - drug effects Microglia - metabolism Midkine Neuroinflammation Pleiotrophin Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proto-Oncogene Proteins c-fyn - metabolism Signal Transduction - drug effects
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