Pharmacogenetics of trazodone in healthy volunteers: association with pharmacokinetics, pharmacodynamics and safety

The aim was to evaluate the effect of polymorphisms in metabolizing enzymes and transporters on the pharmacokinetics, pharmacodynamics and adverse effects of trazodone in healthy volunteers. 36 healthy volunteers receiving a single 100-mg oral dose of trazodone were genotyped for 11 variants in , ,...

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Veröffentlicht in:	Pharmacogenomics 2017-11, Vol.18 (16), p.1491-1502
Hauptverfasser:	Saiz-Rodríguez, Miriam, Belmonte, Carmen, Derqui-Fernández, Nieves, Cabaleiro, Teresa, Román, Manuel, Ochoa, Dolores, Talegón, María, Ovejero-Benito, María C, Abad-Santos, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Antidepressants ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Blood pressure Chlorophenylpiperazine Clinical trials CYP2D6 protein Cytochrome P450 Drug dosages Enzymes Female Gender differences Genotype Genotype & phenotype Glycoproteins Healthy Volunteers Humans Laboratories Liquid chromatography Male Mass spectroscopy Metabolites Pharmacodynamics Pharmacogenetics Pharmacogenetics - methods Pharmacokinetics Poisoning Polymorphism, Single Nucleotide - genetics polymorphisms Population safety Serotonin trazodone Trazodone - pharmacokinetics Trazodone - pharmacology Young Adult
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