Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180

Specific cell populations leading the local invasion of cancer are called “leading cells”. However, the underlying mechanisms are unclear. Here, we identified leading cells in pancreatic cancer and determined how these cells lead and promote cancer cell invasion in the extracellular matrix (ECM). Us...

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Veröffentlicht in:	Cancer letters 2018-01, Vol.412, p.143-154
Hauptverfasser:	Koikawa, Kazuhiro, Ohuchida, Kenoki, Takesue, Shin, Ando, Yohei, Kibe, Shin, Nakayama, Hiromichi, Endo, Sho, Abe, Toshiya, Okumura, Takashi, Horioka, Kohei, Sada, Masafumi, Iwamoto, Chika, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohuchida, Riichi, Manabe, Tatsuya, Ohtsuka, Takao, Nagai, Eishi, Mizumoto, Kazuhiro, Hashizume, Makoto, Nakamura, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animal models Breast cancer Cardiac Myosins - metabolism Cell division Cell Line, Tumor Collagen Collagen - chemistry Endo180 Extracellular matrix Extracellular Matrix - chemistry Extracellular matrix remodeling Fabric analysis Fiber orientation Fibers Fibroblasts Humans Invasiveness Leading cells Medical prognosis Metastasis Myosin Myosin Light Chains - metabolism Neoplasm Invasiveness Pancreatic cancer Pancreatic Neoplasms - pathology Pancreatic stellate cells Pancreatic Stellate Cells - physiology Parallel fibers Phosphorylation Receptors, Mitogen - physiology Rodents Signal transduction Stellate cells Transplantation
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