Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

Cardiovascular mortality risk remains high among patients with type 2 diabetes. Oxidative stress indicated by high urinary excretion of the biomarker for RNA oxidation, 8-oxo-7,8-dihydroguanosine (8-oxoGuo), is associated with an increased risk of death in newly diagnosed and treated patients. We as...

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Veröffentlicht in:	Diabetes care 2017-12, Vol.40 (12), p.1771-1778
Hauptverfasser:	Kjær, Laura K, Cejvanovic, Vanja, Henriksen, Trine, Petersen, Kasper M, Hansen, Torben, Pedersen, Oluf, Christensen, Cramer K, Torp-Pedersen, Christian, Gerds, Thomas A, Brandslund, Ivan, Mandrup-Poulsen, Thomas, Poulsen, Henrik E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Biomarkers - urine Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Cardiovascular Diseases - urine Cohort analysis Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - mortality Diabetes Mellitus, Type 2 - urine Excretion Fatalities Female Guanosine - analogs & derivatives Guanosine - urine Health risks Humans Kaplan-Meier Estimate Male Middle Aged Mortality Oxidation Oxidation-Reduction Oxidative Stress Patients Proportional Hazards Models Prospective Studies Research design Ribonucleic acid Risk RNA RNA - metabolism
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