Association between chronic kidney disease and the cognitive function in subjects without overt dementia
The association between cognitive function and clinical parameters of chronic kidney disease (CKD) was investigated in Japanese patients without overt dementia in a cross-sectional study. A population of 497 patients whose cognitive function had been examined using the mini-mental state examination...
Gespeichert in:
| Veröffentlicht in: | Clinical nephrology 2018-05, Vol.89 (5), p.330-335 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 335 |
|---|---|
| container_issue | 5 |
| container_start_page | 330 |
| container_title | Clinical nephrology |
| container_volume | 89 |
| creator | Ito, Hiroyuki Antoku, Shinichi Mori, Toshiko Nakagawa, Yoshitaka Mizoguchi, Katsumi Matsumoto, Suzuko Omoto, Takashi Shinozaki, Masahiro Nishio, Shinya Abe, Mariko Mifune, Mizuo Togane, Michiko |
| description | The association between cognitive function and clinical parameters of chronic kidney disease (CKD) was investigated in Japanese patients without overt dementia in a cross-sectional study.
A population of 497 patients whose cognitive function had been examined using the mini-mental state examination (MMSE) were screened for this study. After the exclusion of 306 subjects who showed overt dementia, the association between the MMSE score and clinical characteristics was investigated in 191 subjects (male: 55%, age: 69 ± 12 years).
The mean MMSE score of the study subjects was 26.7 ± 2.0. The MMSE score was negatively correlated with the patients' age and positively with the estimated glomerular filtration rate. It was significantly associated with age and proteinuria based on a multivariate analysis. The scores of "temporal orientation", "attention and calculation", and "remote memory" subitems of MMSE were significantly lower in the subjects ≥ 70 years of age than in those |
| doi_str_mv | 10.5414/CN109188 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1954432121</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1954432121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-97b18336e2c5f6a01c0bbc5267f0b3b1afb9aabc1cc8ca2bd53254fcab79c1823</originalsourceid><addsrcrecordid>eNpdkE1PAjEQQHvQCKKJv8A08eIF7bRbdvdIiF8J0YueN-3srBShxW1Xwr8XFTRxLnN58zJ5jJ2BuNIZZNeTRxAlFMUB6wslYCgyJXrsOMa5EFIUqjhiPVkKnedK99lsHGNAZ5ILnltKayLPcdYG75C_udrThtcukonEja95mhHH8Opdch_Em87j96XzPHZ2TpgiX7s0C13i4YPaxGtakk_OnLDDxiwine72gL3c3jxP7ofTp7uHyXg6RAWQhmVuoVBqRBJ1MzICUFiLWo7yRlhlwTS2NMYiIBZopK21kjpr0Ni8RCikGrDLH--qDe8dxVQtXURaLIyn0MUKSp1lSoKELXrxD52HrvXb7yoJ28lAZ-WfENsQY0tNtWrd0rSbCkT1VbzaF9-i5zthZ5dU_4L73OoTdnt-gw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2111141549</pqid></control><display><type>article</type><title>Association between chronic kidney disease and the cognitive function in subjects without overt dementia</title><source>Alma/SFX Local Collection</source><creator>Ito, Hiroyuki ; Antoku, Shinichi ; Mori, Toshiko ; Nakagawa, Yoshitaka ; Mizoguchi, Katsumi ; Matsumoto, Suzuko ; Omoto, Takashi ; Shinozaki, Masahiro ; Nishio, Shinya ; Abe, Mariko ; Mifune, Mizuo ; Togane, Michiko</creator><creatorcontrib>Ito, Hiroyuki ; Antoku, Shinichi ; Mori, Toshiko ; Nakagawa, Yoshitaka ; Mizoguchi, Katsumi ; Matsumoto, Suzuko ; Omoto, Takashi ; Shinozaki, Masahiro ; Nishio, Shinya ; Abe, Mariko ; Mifune, Mizuo ; Togane, Michiko</creatorcontrib><description>The association between cognitive function and clinical parameters of chronic kidney disease (CKD) was investigated in Japanese patients without overt dementia in a cross-sectional study.
A population of 497 patients whose cognitive function had been examined using the mini-mental state examination (MMSE) were screened for this study. After the exclusion of 306 subjects who showed overt dementia, the association between the MMSE score and clinical characteristics was investigated in 191 subjects (male: 55%, age: 69 ± 12 years).
The mean MMSE score of the study subjects was 26.7 ± 2.0. The MMSE score was negatively correlated with the patients' age and positively with the estimated glomerular filtration rate. It was significantly associated with age and proteinuria based on a multivariate analysis. The scores of "temporal orientation", "attention and calculation", and "remote memory" subitems of MMSE were significantly lower in the subjects ≥ 70 years of age than in those < 70 years of age. The scores of "temporal orientation" (4.3 ± 0.8 vs. 4.7 ± 0.6), "attention and calculation" (2.9 ± 1.6 vs. 3.9 ± 1.5), and "stage command" (2.7 ± 0.5 vs. 2.9 ± 0.3) were significantly lower in the subjects with proteinuria than in those without.
Cognitive function was disturbed even in CKD patients without overt dementia. Intervention in patients with risk factors is deemed important for preventing future reductions in cognitive and renal functions in CKD patients without dementia.
.</description><identifier>ISSN: 0301-0430</identifier><identifier>DOI: 10.5414/CN109188</identifier><identifier>PMID: 29057735</identifier><language>eng</language><publisher>Germany: Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG</publisher><subject>Age ; Alzheimer's disease ; Ankle ; Blood pressure ; Body mass index ; Carotid arteries ; Cholesterol ; Cognitive ability ; Creatinine ; Dementia ; Diabetes ; High density lipoprotein ; Hypertension ; Kidney diseases ; Metabolism ; Multivariate analysis ; Stroke</subject><ispartof>Clinical nephrology, 2018-05, Vol.89 (5), p.330-335</ispartof><rights>Copyright Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-97b18336e2c5f6a01c0bbc5267f0b3b1afb9aabc1cc8ca2bd53254fcab79c1823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29057735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Antoku, Shinichi</creatorcontrib><creatorcontrib>Mori, Toshiko</creatorcontrib><creatorcontrib>Nakagawa, Yoshitaka</creatorcontrib><creatorcontrib>Mizoguchi, Katsumi</creatorcontrib><creatorcontrib>Matsumoto, Suzuko</creatorcontrib><creatorcontrib>Omoto, Takashi</creatorcontrib><creatorcontrib>Shinozaki, Masahiro</creatorcontrib><creatorcontrib>Nishio, Shinya</creatorcontrib><creatorcontrib>Abe, Mariko</creatorcontrib><creatorcontrib>Mifune, Mizuo</creatorcontrib><creatorcontrib>Togane, Michiko</creatorcontrib><title>Association between chronic kidney disease and the cognitive function in subjects without overt dementia</title><title>Clinical nephrology</title><addtitle>Clin Nephrol</addtitle><description>The association between cognitive function and clinical parameters of chronic kidney disease (CKD) was investigated in Japanese patients without overt dementia in a cross-sectional study.
A population of 497 patients whose cognitive function had been examined using the mini-mental state examination (MMSE) were screened for this study. After the exclusion of 306 subjects who showed overt dementia, the association between the MMSE score and clinical characteristics was investigated in 191 subjects (male: 55%, age: 69 ± 12 years).
The mean MMSE score of the study subjects was 26.7 ± 2.0. The MMSE score was negatively correlated with the patients' age and positively with the estimated glomerular filtration rate. It was significantly associated with age and proteinuria based on a multivariate analysis. The scores of "temporal orientation", "attention and calculation", and "remote memory" subitems of MMSE were significantly lower in the subjects ≥ 70 years of age than in those < 70 years of age. The scores of "temporal orientation" (4.3 ± 0.8 vs. 4.7 ± 0.6), "attention and calculation" (2.9 ± 1.6 vs. 3.9 ± 1.5), and "stage command" (2.7 ± 0.5 vs. 2.9 ± 0.3) were significantly lower in the subjects with proteinuria than in those without.
Cognitive function was disturbed even in CKD patients without overt dementia. Intervention in patients with risk factors is deemed important for preventing future reductions in cognitive and renal functions in CKD patients without dementia.
.</description><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Ankle</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Carotid arteries</subject><subject>Cholesterol</subject><subject>Cognitive ability</subject><subject>Creatinine</subject><subject>Dementia</subject><subject>Diabetes</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Metabolism</subject><subject>Multivariate analysis</subject><subject>Stroke</subject><issn>0301-0430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1PAjEQQHvQCKKJv8A08eIF7bRbdvdIiF8J0YueN-3srBShxW1Xwr8XFTRxLnN58zJ5jJ2BuNIZZNeTRxAlFMUB6wslYCgyJXrsOMa5EFIUqjhiPVkKnedK99lsHGNAZ5ILnltKayLPcdYG75C_udrThtcukonEja95mhHH8Opdch_Em87j96XzPHZ2TpgiX7s0C13i4YPaxGtakk_OnLDDxiwine72gL3c3jxP7ofTp7uHyXg6RAWQhmVuoVBqRBJ1MzICUFiLWo7yRlhlwTS2NMYiIBZopK21kjpr0Ni8RCikGrDLH--qDe8dxVQtXURaLIyn0MUKSp1lSoKELXrxD52HrvXb7yoJ28lAZ-WfENsQY0tNtWrd0rSbCkT1VbzaF9-i5zthZ5dU_4L73OoTdnt-gw</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Ito, Hiroyuki</creator><creator>Antoku, Shinichi</creator><creator>Mori, Toshiko</creator><creator>Nakagawa, Yoshitaka</creator><creator>Mizoguchi, Katsumi</creator><creator>Matsumoto, Suzuko</creator><creator>Omoto, Takashi</creator><creator>Shinozaki, Masahiro</creator><creator>Nishio, Shinya</creator><creator>Abe, Mariko</creator><creator>Mifune, Mizuo</creator><creator>Togane, Michiko</creator><general>Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Association between chronic kidney disease and the cognitive function in subjects without overt dementia</title><author>Ito, Hiroyuki ; Antoku, Shinichi ; Mori, Toshiko ; Nakagawa, Yoshitaka ; Mizoguchi, Katsumi ; Matsumoto, Suzuko ; Omoto, Takashi ; Shinozaki, Masahiro ; Nishio, Shinya ; Abe, Mariko ; Mifune, Mizuo ; Togane, Michiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-97b18336e2c5f6a01c0bbc5267f0b3b1afb9aabc1cc8ca2bd53254fcab79c1823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Ankle</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Carotid arteries</topic><topic>Cholesterol</topic><topic>Cognitive ability</topic><topic>Creatinine</topic><topic>Dementia</topic><topic>Diabetes</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Kidney diseases</topic><topic>Metabolism</topic><topic>Multivariate analysis</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Antoku, Shinichi</creatorcontrib><creatorcontrib>Mori, Toshiko</creatorcontrib><creatorcontrib>Nakagawa, Yoshitaka</creatorcontrib><creatorcontrib>Mizoguchi, Katsumi</creatorcontrib><creatorcontrib>Matsumoto, Suzuko</creatorcontrib><creatorcontrib>Omoto, Takashi</creatorcontrib><creatorcontrib>Shinozaki, Masahiro</creatorcontrib><creatorcontrib>Nishio, Shinya</creatorcontrib><creatorcontrib>Abe, Mariko</creatorcontrib><creatorcontrib>Mifune, Mizuo</creatorcontrib><creatorcontrib>Togane, Michiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Hiroyuki</au><au>Antoku, Shinichi</au><au>Mori, Toshiko</au><au>Nakagawa, Yoshitaka</au><au>Mizoguchi, Katsumi</au><au>Matsumoto, Suzuko</au><au>Omoto, Takashi</au><au>Shinozaki, Masahiro</au><au>Nishio, Shinya</au><au>Abe, Mariko</au><au>Mifune, Mizuo</au><au>Togane, Michiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between chronic kidney disease and the cognitive function in subjects without overt dementia</atitle><jtitle>Clinical nephrology</jtitle><addtitle>Clin Nephrol</addtitle><date>2018-05</date><risdate>2018</risdate><volume>89</volume><issue>5</issue><spage>330</spage><epage>335</epage><pages>330-335</pages><issn>0301-0430</issn><abstract>The association between cognitive function and clinical parameters of chronic kidney disease (CKD) was investigated in Japanese patients without overt dementia in a cross-sectional study.
A population of 497 patients whose cognitive function had been examined using the mini-mental state examination (MMSE) were screened for this study. After the exclusion of 306 subjects who showed overt dementia, the association between the MMSE score and clinical characteristics was investigated in 191 subjects (male: 55%, age: 69 ± 12 years).
The mean MMSE score of the study subjects was 26.7 ± 2.0. The MMSE score was negatively correlated with the patients' age and positively with the estimated glomerular filtration rate. It was significantly associated with age and proteinuria based on a multivariate analysis. The scores of "temporal orientation", "attention and calculation", and "remote memory" subitems of MMSE were significantly lower in the subjects ≥ 70 years of age than in those < 70 years of age. The scores of "temporal orientation" (4.3 ± 0.8 vs. 4.7 ± 0.6), "attention and calculation" (2.9 ± 1.6 vs. 3.9 ± 1.5), and "stage command" (2.7 ± 0.5 vs. 2.9 ± 0.3) were significantly lower in the subjects with proteinuria than in those without.
Cognitive function was disturbed even in CKD patients without overt dementia. Intervention in patients with risk factors is deemed important for preventing future reductions in cognitive and renal functions in CKD patients without dementia.
.</abstract><cop>Germany</cop><pub>Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG</pub><pmid>29057735</pmid><doi>10.5414/CN109188</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-0430 |
| ispartof | Clinical nephrology, 2018-05, Vol.89 (5), p.330-335 |
| issn | 0301-0430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1954432121 |
| source | Alma/SFX Local Collection |
| subjects | Age Alzheimer's disease Ankle Blood pressure Body mass index Carotid arteries Cholesterol Cognitive ability Creatinine Dementia Diabetes High density lipoprotein Hypertension Kidney diseases Metabolism Multivariate analysis Stroke |
| title | Association between chronic kidney disease and the cognitive function in subjects without overt dementia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A13%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20chronic%20kidney%20disease%20and%20the%20cognitive%20function%20in%20subjects%20without%20overt%20dementia&rft.jtitle=Clinical%20nephrology&rft.au=Ito,%20Hiroyuki&rft.date=2018-05&rft.volume=89&rft.issue=5&rft.spage=330&rft.epage=335&rft.pages=330-335&rft.issn=0301-0430&rft_id=info:doi/10.5414/CN109188&rft_dat=%3Cproquest_cross%3E1954432121%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2111141549&rft_id=info:pmid/29057735&rfr_iscdi=true |