Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk

Alcohol metabolizing enzymes, such as the alcohol dehydrogenases and the aldehyde dehydrogenases, regulate the levels of acetaldehyde in the blood and play an important role in the development and maintenance of alcohol addiction. Recent genome‐wide systematic searches found associations between a s...

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Veröffentlicht in:	Addiction biology 2019-01, Vol.24 (1), p.110-120
Hauptverfasser:	Bach, Patrick, Zois, Evangelos, Vollstädt‐Klein, Sabine, Kirsch, Martina, Hoffmann, Sabine, Jorde, Anne, Frank, Josef, Charlet, Katrin, Treutlein, Jens, Beck, Anne, Heinz, Andreas, Walter, Henrik, Rietschel, Marcella, Kiefer, Falk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Addictions Addictive behaviors ADH gene polymorphism Adult Alcohol Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol Drinking - genetics Alcohol use alcoholism Alcoholism - genetics Alleles Brain - diagnostic imaging Brain - pathology Craving Dehydrogenases Drinking behavior Drug addiction Drug dependence Enzymes Female Gene polymorphism Genetic diversity Genomes Genotype & phenotype Gray Matter - diagnostic imaging Gray Matter - pathology gray matter volume Humans Magnetic resonance imaging Male Middle Aged MRI Neuroimaging Organ Size - genetics Polymorphism Polymorphism, Single Nucleotide Proportional Hazards Models Recurrence relapse rs1789891 Single-nucleotide polymorphism Substantia grisea Temporal Lobe - diagnostic imaging Temporal Lobe - pathology
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