Clinical and prognostic value of the C‐Met/HGF signaling pathway in cervical cancer
Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV‐positive...
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| Veröffentlicht in: | Journal of cellular physiology 2018-06, Vol.233 (6), p.4490-4496 |
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| creator | Boromand, Nadia Hasanzadeh, Malihe ShahidSales, Soodabeh Farazestanian, Marjaneh Gharib, Masoumeh Fiuji, Hamid Behboodi, Negin Ghobadi, Niloofar Hassanian, Seyed Mahdi Ferns, Gordon A. Avan, Amir |
| description | Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV‐positive patients had a higher serum level of HGF or c‐Met protein, compared with HPV‐negative patients. c‐Met or HGF overexpression in lesions of cervical cancer is reported to be related to a poorer prognosis, and hence this may be of value as a prognostic and predictive biomarker. Several approaches have been developed for targeting HGF and/or c‐Met. One of these is crizotinib (a dual c‐Met/ALK inhibitor). This has been approved by FDA for the treatment of lung‐cancer. Further investigations are required to evaluate and optimize the use of c‐Met inhibitors in cervical cancer or parallel targeting signalling pathway associated/activated via MET/HGF pathway. The main aim of current review was to give an overview of the potential of the c‐Met/HGF pathway as a prognostic, or predictive biomarker in cervical cancer.
Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. |
| doi_str_mv | 10.1002/jcp.26232 |
| format | Article |
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Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.26232</identifier><identifier>PMID: 29058790</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aberration ; Animals ; Biomarkers ; c-Met protein ; Cancer ; Cell Movement ; Cell Proliferation ; Cervical cancer ; Cervix ; c‐Met/HGF pathway ; Disease Progression ; Female ; Hepatocyte Growth Factor - genetics ; Hepatocyte Growth Factor - metabolism ; Host-Pathogen Interactions ; HPV ; Human papillomavirus ; Humans ; Lesions ; Lung cancer ; MET protein ; Metastases ; Neoplasm Invasiveness ; Papillomaviridae - pathogenicity ; Patients ; Proto-Oncogene Proteins c-met - genetics ; Proto-Oncogene Proteins c-met - metabolism ; Signal Transduction ; Signaling ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - virology</subject><ispartof>Journal of cellular physiology, 2018-06, Vol.233 (6), p.4490-4496</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-2b7d12c785cfb8954c71b8693d8e0878be5d6b18919c3c877cdf2a72bc21529c3</citedby><cites>FETCH-LOGICAL-c3532-2b7d12c785cfb8954c71b8693d8e0878be5d6b18919c3c877cdf2a72bc21529c3</cites><orcidid>0000-0002-4968-0962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.26232$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.26232$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29058790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boromand, Nadia</creatorcontrib><creatorcontrib>Hasanzadeh, Malihe</creatorcontrib><creatorcontrib>ShahidSales, Soodabeh</creatorcontrib><creatorcontrib>Farazestanian, Marjaneh</creatorcontrib><creatorcontrib>Gharib, Masoumeh</creatorcontrib><creatorcontrib>Fiuji, Hamid</creatorcontrib><creatorcontrib>Behboodi, Negin</creatorcontrib><creatorcontrib>Ghobadi, Niloofar</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><title>Clinical and prognostic value of the C‐Met/HGF signaling pathway in cervical cancer</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV‐positive patients had a higher serum level of HGF or c‐Met protein, compared with HPV‐negative patients. c‐Met or HGF overexpression in lesions of cervical cancer is reported to be related to a poorer prognosis, and hence this may be of value as a prognostic and predictive biomarker. Several approaches have been developed for targeting HGF and/or c‐Met. One of these is crizotinib (a dual c‐Met/ALK inhibitor). This has been approved by FDA for the treatment of lung‐cancer. Further investigations are required to evaluate and optimize the use of c‐Met inhibitors in cervical cancer or parallel targeting signalling pathway associated/activated via MET/HGF pathway. The main aim of current review was to give an overview of the potential of the c‐Met/HGF pathway as a prognostic, or predictive biomarker in cervical cancer.
Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target.</description><subject>Aberration</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>c-Met protein</subject><subject>Cancer</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>c‐Met/HGF pathway</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Hepatocyte Growth Factor - genetics</subject><subject>Hepatocyte Growth Factor - metabolism</subject><subject>Host-Pathogen Interactions</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Lesions</subject><subject>Lung cancer</subject><subject>MET protein</subject><subject>Metastases</subject><subject>Neoplasm Invasiveness</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Patients</subject><subject>Proto-Oncogene Proteins c-met - genetics</subject><subject>Proto-Oncogene Proteins c-met - metabolism</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqUw8ALIEgsMaW3nx_aIItqCimCgs-U4TusqTUKctOrGI_CMPAmmKQxITNe6Pj76_AFwidEQI0RGK1UNSUR8cgT6GHHqBVFIjkHf3WGPhwHugTNrVwghzn3_FPQIRyGjHPXBPM5NYZTMoSxSWNXloihtYxTcyLzVsMxgs9Qw_nz_eNLNaDoZQ2sWhXSPFrCSzXIrd9AUUOl6s7coWbjzOTjJZG71xWEOwHx8_xpPvdnz5CG-m3nKD33ikYSmmCjKQpUlzAVVFCcs4n7KNGKUJTpMowQzjrnyFaNUpRmRlCSK4JC43QDcdF4X_K3VthFrY5XOc1nosrUCO2dAUOAjh17_QVdlW7ufWEEQYoTRkDNH3XaUqktra52JqjZrWe8ERuK7a-G6FvuuHXt1MLbJWqe_5E-5Dhh1wNbkeve_STzGL53yC30Zh0Q</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Boromand, Nadia</creator><creator>Hasanzadeh, Malihe</creator><creator>ShahidSales, Soodabeh</creator><creator>Farazestanian, Marjaneh</creator><creator>Gharib, Masoumeh</creator><creator>Fiuji, Hamid</creator><creator>Behboodi, Negin</creator><creator>Ghobadi, Niloofar</creator><creator>Hassanian, Seyed Mahdi</creator><creator>Ferns, Gordon A.</creator><creator>Avan, Amir</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid></search><sort><creationdate>201806</creationdate><title>Clinical and prognostic value of the C‐Met/HGF signaling pathway in cervical cancer</title><author>Boromand, Nadia ; Hasanzadeh, Malihe ; ShahidSales, Soodabeh ; Farazestanian, Marjaneh ; Gharib, Masoumeh ; Fiuji, Hamid ; Behboodi, Negin ; Ghobadi, Niloofar ; Hassanian, Seyed Mahdi ; Ferns, Gordon A. ; Avan, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-2b7d12c785cfb8954c71b8693d8e0878be5d6b18919c3c877cdf2a72bc21529c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aberration</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>c-Met protein</topic><topic>Cancer</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>c‐Met/HGF pathway</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Hepatocyte Growth Factor - genetics</topic><topic>Hepatocyte Growth Factor - metabolism</topic><topic>Host-Pathogen Interactions</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Lesions</topic><topic>Lung cancer</topic><topic>MET protein</topic><topic>Metastases</topic><topic>Neoplasm Invasiveness</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Patients</topic><topic>Proto-Oncogene Proteins c-met - genetics</topic><topic>Proto-Oncogene Proteins c-met - metabolism</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boromand, Nadia</creatorcontrib><creatorcontrib>Hasanzadeh, Malihe</creatorcontrib><creatorcontrib>ShahidSales, Soodabeh</creatorcontrib><creatorcontrib>Farazestanian, Marjaneh</creatorcontrib><creatorcontrib>Gharib, Masoumeh</creatorcontrib><creatorcontrib>Fiuji, Hamid</creatorcontrib><creatorcontrib>Behboodi, Negin</creatorcontrib><creatorcontrib>Ghobadi, Niloofar</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boromand, Nadia</au><au>Hasanzadeh, Malihe</au><au>ShahidSales, Soodabeh</au><au>Farazestanian, Marjaneh</au><au>Gharib, Masoumeh</au><au>Fiuji, Hamid</au><au>Behboodi, Negin</au><au>Ghobadi, Niloofar</au><au>Hassanian, Seyed Mahdi</au><au>Ferns, Gordon A.</au><au>Avan, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and prognostic value of the C‐Met/HGF signaling pathway in cervical cancer</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>233</volume><issue>6</issue><spage>4490</spage><epage>4496</epage><pages>4490-4496</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target. Furthermore, HPV‐positive patients had a higher serum level of HGF or c‐Met protein, compared with HPV‐negative patients. c‐Met or HGF overexpression in lesions of cervical cancer is reported to be related to a poorer prognosis, and hence this may be of value as a prognostic and predictive biomarker. Several approaches have been developed for targeting HGF and/or c‐Met. One of these is crizotinib (a dual c‐Met/ALK inhibitor). This has been approved by FDA for the treatment of lung‐cancer. Further investigations are required to evaluate and optimize the use of c‐Met inhibitors in cervical cancer or parallel targeting signalling pathway associated/activated via MET/HGF pathway. The main aim of current review was to give an overview of the potential of the c‐Met/HGF pathway as a prognostic, or predictive biomarker in cervical cancer.
Aberrant activation of the HGF/c‐Met signalling pathway is reported to be associated with cell proliferation, progression, and metastasis features of several tumor types, including cervical cancer, suggesting that it may be of potential value as a novel therapeutic target.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29058790</pmid><doi>10.1002/jcp.26232</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid></addata></record> |
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| subjects | Aberration Animals Biomarkers c-Met protein Cancer Cell Movement Cell Proliferation Cervical cancer Cervix c‐Met/HGF pathway Disease Progression Female Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Host-Pathogen Interactions HPV Human papillomavirus Humans Lesions Lung cancer MET protein Metastases Neoplasm Invasiveness Papillomaviridae - pathogenicity Patients Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Signal Transduction Signaling Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology |
| title | Clinical and prognostic value of the C‐Met/HGF signaling pathway in cervical cancer |
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