Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells

Summary Ribonucleotide reductase (RR) is the enzyme that catalyses the rate‐limiting step in DNA synthesis, the production of deoxynucleotides. RR activity is markedly elevated in tumour tissue and is crucial for cell division. It is therefore an excellent target for cancer chemotherapy. This study...

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Veröffentlicht in:	British journal of haematology 2006-10, Vol.135 (1), p.52-61
Hauptverfasser:	Raje, N., Kumar, S., Hideshima, T., Ishitsuka, K., Yasui, H., Chhetri, S., Vallet, S., Vonescu, E., Shiraishi, N., Kiziltepe, T., Elford, H.L., Munshi, N.C., Anderson, K.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents, Alkylating - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences Caspases - physiology Cell Cycle - drug effects Cell Survival - drug effects DNA Repair - drug effects DNA Repair - genetics DNA synthesis Dose-Response Relationship, Drug Down-Regulation - drug effects Drug Evaluation, Preclinical Drug Synergism Enzyme Inhibitors - pharmacology Gene Expression Regulation, Neoplastic - drug effects Hematologic and hematopoietic diseases Humans Hydroxamic Acids - pharmacology Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Melphalan - pharmacology Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology myeloma Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism ribonucleotide reductase inhibitors Ribonucleotide Reductases - antagonists & inhibitors Tumor Cells, Cultured
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