A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers

Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of sev...

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Veröffentlicht in:Biosensors & bioelectronics 2018-03, Vol.101, p.96-102
Hauptverfasser: Kim, Hanbi, Lee, Jong Uk, Song, Sojin, Kim, Soohyun, Sim, Sang Jun
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creator Kim, Hanbi
Lee, Jong Uk
Song, Sojin
Kim, Soohyun
Sim, Sang Jun
description Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of several lesions to improve accuracy. Amyloid beta 1–40, 1–42 and τ (tau) protein are milestones in AD pathology and can be used as main screening and diagnostic target markers. Here, we suggest a highly selective biosensor for detection of AD core biomarkers on one platform through distinct localized surface plasmon resonance (LSPR) depending on gold nanoparticles shapes, called a shape-code biosensor. This plasmonic sensor consists of only gold nanoparticles and antibody, but does not need additory methods for precise separation from multifarious samples and identification of markers. Under physiological condition, we determined a detection limit of 34.9fM for amyloid beta (Aβ) 1–40, 26fM for Aβ 1–42 and 23.6fM for τ protein corresponding to the ~ 1, ~ 2.23 and ~ 3.12nm of Rayleigh scattering peak shift on shape-code plasmon system for each biomarker in mimicked blood. This is the first highly sensitive shape-code biosensor to detect AD biomarkers which can be used to diagnose AD easily in the future. •A shape-code biosensor is developed for multi-analysis of Alzheimer’s disease.•Colorimetric characterization of shape-code AuNPs enables the multiplexed analysis.•We detected femto molar range of hallmarks of Alzheimer’s disease in mimicked blood.•This platform is diagnosable for diseases with great sensitive and multi-analysis.
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subjects Alzheimer Disease - diagnosis
Alzheimer's disease (AD)
Amyloid beta-Peptides - analysis
Biomarkers - analysis
Equipment Design
Gold - chemistry
Gold nanoparticles (AuNPs)
Humans
Limit of Detection
Localized surface plasmon resonance (LSPR)
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Multiplex detection
Peptide Fragments - analysis
Plasmonic biosensors
Shape-code
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
title A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers
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