A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers
Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of sev...
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Veröffentlicht in: | Biosensors & bioelectronics 2018-03, Vol.101, p.96-102 |
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description | Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of several lesions to improve accuracy. Amyloid beta 1–40, 1–42 and τ (tau) protein are milestones in AD pathology and can be used as main screening and diagnostic target markers. Here, we suggest a highly selective biosensor for detection of AD core biomarkers on one platform through distinct localized surface plasmon resonance (LSPR) depending on gold nanoparticles shapes, called a shape-code biosensor. This plasmonic sensor consists of only gold nanoparticles and antibody, but does not need additory methods for precise separation from multifarious samples and identification of markers. Under physiological condition, we determined a detection limit of 34.9fM for amyloid beta (Aβ) 1–40, 26fM for Aβ 1–42 and 23.6fM for τ protein corresponding to the ~ 1, ~ 2.23 and ~ 3.12nm of Rayleigh scattering peak shift on shape-code plasmon system for each biomarker in mimicked blood. This is the first highly sensitive shape-code biosensor to detect AD biomarkers which can be used to diagnose AD easily in the future.
•A shape-code biosensor is developed for multi-analysis of Alzheimer’s disease.•Colorimetric characterization of shape-code AuNPs enables the multiplexed analysis.•We detected femto molar range of hallmarks of Alzheimer’s disease in mimicked blood.•This platform is diagnosable for diseases with great sensitive and multi-analysis. |
doi_str_mv | 10.1016/j.bios.2017.10.018 |
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•A shape-code biosensor is developed for multi-analysis of Alzheimer’s disease.•Colorimetric characterization of shape-code AuNPs enables the multiplexed analysis.•We detected femto molar range of hallmarks of Alzheimer’s disease in mimicked blood.•This platform is diagnosable for diseases with great sensitive and multi-analysis.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2017.10.018</identifier><identifier>PMID: 29054022</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Alzheimer Disease - diagnosis ; Alzheimer's disease (AD) ; Amyloid beta-Peptides - analysis ; Biomarkers - analysis ; Equipment Design ; Gold - chemistry ; Gold nanoparticles (AuNPs) ; Humans ; Limit of Detection ; Localized surface plasmon resonance (LSPR) ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Multiplex detection ; Peptide Fragments - analysis ; Plasmonic biosensors ; Shape-code ; Surface Plasmon Resonance - instrumentation ; Surface Plasmon Resonance - methods</subject><ispartof>Biosensors & bioelectronics, 2018-03, Vol.101, p.96-102</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-d4f123398cb0a2b2488eff8bd4bf563fa7137e3ff6c9d6424844e797aff9d1463</citedby><cites>FETCH-LOGICAL-c422t-d4f123398cb0a2b2488eff8bd4bf563fa7137e3ff6c9d6424844e797aff9d1463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bios.2017.10.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29054022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hanbi</creatorcontrib><creatorcontrib>Lee, Jong Uk</creatorcontrib><creatorcontrib>Song, Sojin</creatorcontrib><creatorcontrib>Kim, Soohyun</creatorcontrib><creatorcontrib>Sim, Sang Jun</creatorcontrib><title>A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of several lesions to improve accuracy. Amyloid beta 1–40, 1–42 and τ (tau) protein are milestones in AD pathology and can be used as main screening and diagnostic target markers. Here, we suggest a highly selective biosensor for detection of AD core biomarkers on one platform through distinct localized surface plasmon resonance (LSPR) depending on gold nanoparticles shapes, called a shape-code biosensor. This plasmonic sensor consists of only gold nanoparticles and antibody, but does not need additory methods for precise separation from multifarious samples and identification of markers. Under physiological condition, we determined a detection limit of 34.9fM for amyloid beta (Aβ) 1–40, 26fM for Aβ 1–42 and 23.6fM for τ protein corresponding to the ~ 1, ~ 2.23 and ~ 3.12nm of Rayleigh scattering peak shift on shape-code plasmon system for each biomarker in mimicked blood. This is the first highly sensitive shape-code biosensor to detect AD biomarkers which can be used to diagnose AD easily in the future.
•A shape-code biosensor is developed for multi-analysis of Alzheimer’s disease.•Colorimetric characterization of shape-code AuNPs enables the multiplexed analysis.•We detected femto molar range of hallmarks of Alzheimer’s disease in mimicked blood.•This platform is diagnosable for diseases with great sensitive and multi-analysis.</description><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease (AD)</subject><subject>Amyloid beta-Peptides - analysis</subject><subject>Biomarkers - analysis</subject><subject>Equipment Design</subject><subject>Gold - chemistry</subject><subject>Gold nanoparticles (AuNPs)</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Localized surface plasmon resonance (LSPR)</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Multiplex detection</subject><subject>Peptide Fragments - analysis</subject><subject>Plasmonic biosensors</subject><subject>Shape-code</subject><subject>Surface Plasmon Resonance - instrumentation</subject><subject>Surface Plasmon Resonance - methods</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxa2KqizbfoEeUG70ksX_EicSlxWiUAmJC73Wcuyx1ksSp55sRfn0dbSUI4fRSOP3nvx-hHxldMMoqy_3my5E3HDKVD5sKGs-kBVrlCglF9UJWdG2qsuqrsUpOUPcU0oVa-kncspbWknK-Yr82ha4MxOUNjooRjPGqTc4xDHYYkmHEWMqfJ7h0M9h6uG5cDCDnUMci-iLbf-ygzBAusDCBQSDsBgHk54g4Wfy0Zse4cvrXpOf328er-_K-4fbH9fb-9JKzufSSc-4EG1jO2p4x2XTgPdN52Tnq1p4o5hQILyvbetqmd-lBNUq433rmKzFmnw75k4p_j4AznoIaKHvzQjxgJq1ua9qVMWzlB-lNkXEBF5PKeTv_tWM6oWr3uuluV64LrfMNZvOX_MP3QDuzfIfZBZcHQWQW_4JkDTaAKMFF1KGpV0M7-X_AxlTirk</recordid><startdate>20180315</startdate><enddate>20180315</enddate><creator>Kim, Hanbi</creator><creator>Lee, Jong Uk</creator><creator>Song, Sojin</creator><creator>Kim, Soohyun</creator><creator>Sim, Sang Jun</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180315</creationdate><title>A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers</title><author>Kim, Hanbi ; Lee, Jong Uk ; Song, Sojin ; Kim, Soohyun ; Sim, Sang Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-d4f123398cb0a2b2488eff8bd4bf563fa7137e3ff6c9d6424844e797aff9d1463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease (AD)</topic><topic>Amyloid beta-Peptides - analysis</topic><topic>Biomarkers - analysis</topic><topic>Equipment Design</topic><topic>Gold - chemistry</topic><topic>Gold nanoparticles (AuNPs)</topic><topic>Humans</topic><topic>Limit of Detection</topic><topic>Localized surface plasmon resonance (LSPR)</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Multiplex detection</topic><topic>Peptide Fragments - analysis</topic><topic>Plasmonic biosensors</topic><topic>Shape-code</topic><topic>Surface Plasmon Resonance - instrumentation</topic><topic>Surface Plasmon Resonance - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hanbi</creatorcontrib><creatorcontrib>Lee, Jong Uk</creatorcontrib><creatorcontrib>Song, Sojin</creatorcontrib><creatorcontrib>Kim, Soohyun</creatorcontrib><creatorcontrib>Sim, Sang Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hanbi</au><au>Lee, Jong Uk</au><au>Song, Sojin</au><au>Kim, Soohyun</au><au>Sim, Sang Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2018-03-15</date><risdate>2018</risdate><volume>101</volume><spage>96</spage><epage>102</epage><pages>96-102</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of several lesions to improve accuracy. Amyloid beta 1–40, 1–42 and τ (tau) protein are milestones in AD pathology and can be used as main screening and diagnostic target markers. Here, we suggest a highly selective biosensor for detection of AD core biomarkers on one platform through distinct localized surface plasmon resonance (LSPR) depending on gold nanoparticles shapes, called a shape-code biosensor. This plasmonic sensor consists of only gold nanoparticles and antibody, but does not need additory methods for precise separation from multifarious samples and identification of markers. Under physiological condition, we determined a detection limit of 34.9fM for amyloid beta (Aβ) 1–40, 26fM for Aβ 1–42 and 23.6fM for τ protein corresponding to the ~ 1, ~ 2.23 and ~ 3.12nm of Rayleigh scattering peak shift on shape-code plasmon system for each biomarker in mimicked blood. This is the first highly sensitive shape-code biosensor to detect AD biomarkers which can be used to diagnose AD easily in the future.
•A shape-code biosensor is developed for multi-analysis of Alzheimer’s disease.•Colorimetric characterization of shape-code AuNPs enables the multiplexed analysis.•We detected femto molar range of hallmarks of Alzheimer’s disease in mimicked blood.•This platform is diagnosable for diseases with great sensitive and multi-analysis.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>29054022</pmid><doi>10.1016/j.bios.2017.10.018</doi><tpages>7</tpages></addata></record> |
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subjects | Alzheimer Disease - diagnosis Alzheimer's disease (AD) Amyloid beta-Peptides - analysis Biomarkers - analysis Equipment Design Gold - chemistry Gold nanoparticles (AuNPs) Humans Limit of Detection Localized surface plasmon resonance (LSPR) Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Multiplex detection Peptide Fragments - analysis Plasmonic biosensors Shape-code Surface Plasmon Resonance - instrumentation Surface Plasmon Resonance - methods |
title | A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers |
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