Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark
Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium cha...
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| Veröffentlicht in: | The American journal of cardiology 2017-12, Vol.120 (12), p.2193-2200 |
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| creator | Sundbøll, Jens Adelborg, Kasper Mansfield, Kathryn E. Tomlinson, Laurie A. Schmidt, Morten |
| description | Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%. From 1999 to 2015, a notable increase was observed for angiotensin-converting enzyme inhibitors (from 29 to 105 DDD per 1,000 inhabitants/day ≈260%) and angiotensin II receptor blockers (from 13 to 73 DDD per 1,000 inhabitants/day ≈520%). For diuretics the use remained stable, with a slight decrease (from 89 to 81 DDD per 1,000 inhabitants/day ≈−10%). The use of aldosterone receptor antagonists increased until 2007 and remained unchanged at around 3.5 DDD per 1,000 inhabitants/day thereafter (average change ≈65%). The use of beta blockers doubled during the study period (from 17 to 34 DDD per 1,000 inhabitants/day ≈100%), entirely driven by increasing use of metoprolol. Similar trends were observed for calcium channel blockers (from 34 to 82 DDD per 1,000 inhabitants/day ≈140%), where amlodipine drove the overall increase. In conclusion, antihypertensive drug use has increased remarkably during the past 2 decades. |
| doi_str_mv | 10.1016/j.amjcard.2017.08.042 |
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From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%. From 1999 to 2015, a notable increase was observed for angiotensin-converting enzyme inhibitors (from 29 to 105 DDD per 1,000 inhabitants/day ≈260%) and angiotensin II receptor blockers (from 13 to 73 DDD per 1,000 inhabitants/day ≈520%). For diuretics the use remained stable, with a slight decrease (from 89 to 81 DDD per 1,000 inhabitants/day ≈−10%). The use of aldosterone receptor antagonists increased until 2007 and remained unchanged at around 3.5 DDD per 1,000 inhabitants/day thereafter (average change ≈65%). The use of beta blockers doubled during the study period (from 17 to 34 DDD per 1,000 inhabitants/day ≈100%), entirely driven by increasing use of metoprolol. Similar trends were observed for calcium channel blockers (from 34 to 82 DDD per 1,000 inhabitants/day ≈140%), where amlodipine drove the overall increase. In conclusion, antihypertensive drug use has increased remarkably during the past 2 decades.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2017.08.042</identifier><identifier>PMID: 29054274</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age groups ; Aldosterone ; Angiotensin ; Angiotensin II ; Angiotensin-converting enzyme inhibitors ; Antihypertensive Agents - therapeutic use ; Antihypertensives ; Beta blockers ; Calcium ; Calcium antagonists ; Clinical medicine ; Clinical trials ; Denmark ; Diuretics ; Drug Prescriptions - statistics & numerical data ; Drug Utilization - trends ; Drugs ; Enzyme inhibitors ; Follow-Up Studies ; Forecasting ; Gender ; Heart attacks ; Heart failure ; Humans ; Hypertension ; Hypertension - drug therapy ; Inhabitants ; Inhibitors ; Metoprolol ; Peptidyl-dipeptidase A ; Pharmacy ; Potassium ; Prescription drugs ; Registries ; Retrospective Studies ; Trends ; Women</subject><ispartof>The American journal of cardiology, 2017-12, Vol.120 (12), p.2193-2200</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. Dec 15, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-7a78134761940ace7202d5c93b0975181318a9077cd15ee5f7a0e8e9dddc305f3</citedby><cites>FETCH-LOGICAL-c440t-7a78134761940ace7202d5c93b0975181318a9077cd15ee5f7a0e8e9dddc305f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914917314637$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29054274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sundbøll, Jens</creatorcontrib><creatorcontrib>Adelborg, Kasper</creatorcontrib><creatorcontrib>Mansfield, Kathryn E.</creatorcontrib><creatorcontrib>Tomlinson, Laurie A.</creatorcontrib><creatorcontrib>Schmidt, Morten</creatorcontrib><title>Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%. From 1999 to 2015, a notable increase was observed for angiotensin-converting enzyme inhibitors (from 29 to 105 DDD per 1,000 inhabitants/day ≈260%) and angiotensin II receptor blockers (from 13 to 73 DDD per 1,000 inhabitants/day ≈520%). For diuretics the use remained stable, with a slight decrease (from 89 to 81 DDD per 1,000 inhabitants/day ≈−10%). The use of aldosterone receptor antagonists increased until 2007 and remained unchanged at around 3.5 DDD per 1,000 inhabitants/day thereafter (average change ≈65%). The use of beta blockers doubled during the study period (from 17 to 34 DDD per 1,000 inhabitants/day ≈100%), entirely driven by increasing use of metoprolol. Similar trends were observed for calcium channel blockers (from 34 to 82 DDD per 1,000 inhabitants/day ≈140%), where amlodipine drove the overall increase. In conclusion, antihypertensive drug use has increased remarkably during the past 2 decades.</description><subject>Age groups</subject><subject>Aldosterone</subject><subject>Angiotensin</subject><subject>Angiotensin II</subject><subject>Angiotensin-converting enzyme inhibitors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Beta blockers</subject><subject>Calcium</subject><subject>Calcium antagonists</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Denmark</subject><subject>Diuretics</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Drug Utilization - trends</subject><subject>Drugs</subject><subject>Enzyme inhibitors</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Gender</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Inhabitants</subject><subject>Inhibitors</subject><subject>Metoprolol</subject><subject>Peptidyl-dipeptidase A</subject><subject>Pharmacy</subject><subject>Potassium</subject><subject>Prescription drugs</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Trends</subject><subject>Women</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1vEzEQQC0EomnhJ4BW4tLLLjNeO7ZPqGopRargQHvgZLn2BLwk3mDvBvXf4yiBAxdOo9G8-XqMvULoEHD5dujcZvAuh44Dqg50B4I_YQvUyrRosH_KFgDAW4PCnLDTUoaaIsrlc3bCDUjBlViwmy-0ozQRpfYrudx8clMc068YqLnLlEJpYmou0hS_P24pT5RK3FFzledvzX2hffGK0sblHy_Ys5VbF3p5jGfs_vr93eVNe_v5w8fLi9vWCwFTq5zS2Au1RCPAeVIceJDe9A9glMRaQ-0MKOUDSiK5Ug5Ikwkh-B7kqj9j54e52zz-nKlMdhOLp_XaJRrnYtFIAUpzriv65h90GOec6nWVWkohNBemUvJA-TyWkmlltznWjx4tgt2rtoM9qrZ71Ra0rapr3-vj9PlhQ-Fv1x-3FXh3AKjq2EXKtvhIyVOImfxkwxj_s-I3hrKQNA</recordid><startdate>20171215</startdate><enddate>20171215</enddate><creator>Sundbøll, Jens</creator><creator>Adelborg, Kasper</creator><creator>Mansfield, Kathryn E.</creator><creator>Tomlinson, Laurie A.</creator><creator>Schmidt, Morten</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171215</creationdate><title>Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark</title><author>Sundbøll, Jens ; 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From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%. From 1999 to 2015, a notable increase was observed for angiotensin-converting enzyme inhibitors (from 29 to 105 DDD per 1,000 inhabitants/day ≈260%) and angiotensin II receptor blockers (from 13 to 73 DDD per 1,000 inhabitants/day ≈520%). For diuretics the use remained stable, with a slight decrease (from 89 to 81 DDD per 1,000 inhabitants/day ≈−10%). The use of aldosterone receptor antagonists increased until 2007 and remained unchanged at around 3.5 DDD per 1,000 inhabitants/day thereafter (average change ≈65%). The use of beta blockers doubled during the study period (from 17 to 34 DDD per 1,000 inhabitants/day ≈100%), entirely driven by increasing use of metoprolol. Similar trends were observed for calcium channel blockers (from 34 to 82 DDD per 1,000 inhabitants/day ≈140%), where amlodipine drove the overall increase. In conclusion, antihypertensive drug use has increased remarkably during the past 2 decades.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29054274</pmid><doi>10.1016/j.amjcard.2017.08.042</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Aldosterone Angiotensin Angiotensin II Angiotensin-converting enzyme inhibitors Antihypertensive Agents - therapeutic use Antihypertensives Beta blockers Calcium Calcium antagonists Clinical medicine Clinical trials Denmark Diuretics Drug Prescriptions - statistics & numerical data Drug Utilization - trends Drugs Enzyme inhibitors Follow-Up Studies Forecasting Gender Heart attacks Heart failure Humans Hypertension Hypertension - drug therapy Inhabitants Inhibitors Metoprolol Peptidyl-dipeptidase A Pharmacy Potassium Prescription drugs Registries Retrospective Studies Trends Women |
| title | Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark |
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