Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2

Inhibitory PAS domain protein (IPAS) is a bifunctional protein that downregulates hypoxic gene expression and exerts proapoptotic activity by preventing prosurvival activity of Bcl‐xL and its related factors. Proapoptotic activity of IPAS is attenuated by the activation of the PINK1‐Parkin pathway,...

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Veröffentlicht in:	The FEBS journal 2017-12, Vol.284 (23), p.4115-4127
Hauptverfasser:	Kasai, Shuya, Richardson, Mary J. E., Torii, Satoru, Yasumoto, Ken‐ichi, Shima, Hiroki, Igarashi, Kazuhiko, Itoh, Ken, Sogawa, Kazuhiro, Murayama, Kazutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Bcl-x protein Caspase Caspase 3 - metabolism Caspase-3 Cell death Clustering Degeneration Enzyme Activation - drug effects Enzyme Activation - radiation effects Gene expression HEK293 Cells Humans Hypoxia Imidazoles - pharmacology Inhibitors inhibitory PAS domain protein Irradiation Kinases MAP kinase Mass spectrometry Mass spectroscopy Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - radiation effects mitochondrial clustering Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism MK2 Movement disorders Mutation Neurodegenerative diseases p38 Mitogen-Activated Protein Kinases - metabolism Parkin protein Parkinson's disease PC12 Cells Pheochromocytoma cells Phosphorylation Protein kinase Proteins PTEN-induced putative kinase Pyridines - pharmacology Rats RNA Interference Serine - genetics Serine - metabolism siRNA Transcription Factors - genetics Transcription Factors - metabolism Ultraviolet radiation Ultraviolet Rays
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