A Synthetic CD8α:MyD88 Coreceptor Enhances CD8 + T-cell Responses to Weakly Immunogenic and Lowly Expressed Tumor Antigens

T cell-based immunotherapies are a promising approach for patients with advanced cancers. However, various obstacles limit T-cell efficacy, including suboptimal T-cell receptor (TCR) activation and an immunosuppressive tumor environment. Here, we developed a fusion protein by linking CD8α and MyD88...

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