Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy
Background The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter‐defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT‐RIT. Methods MADIT‐RIT randomized 1,...
Gespeichert in:
| Veröffentlicht in: | Pacing and clinical electrophysiology 2017-12, Vol.40 (12), p.1405-1411 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1411 |
|---|---|
| container_issue | 12 |
| container_start_page | 1405 |
| container_title | Pacing and clinical electrophysiology |
| container_volume | 40 |
| creator | Daimee, Usama A. Vermilye, Katherine Rosero, Spencer Schuger, Claudio D. Daubert, James P. Zareba, Wojciech McNitt, Scott Polonsky, Bronislava Moss, Arthur J. Kutyifa, Valentina |
| description | Background
The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter‐defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT‐RIT.
Methods
MADIT‐RIT randomized 1,500 patients to three ICD programming arms: conventional (Arm A), high‐rate cut‐off (Arm B: ≥200 beats/min), and delayed therapy (Arm C: 60‐second delay for ≥170 beats/min). We evaluated the association between New York Heart Association (NYHA) class III (n = 256) versus class I–II (n = 251) and inappropriate ICD therapy in Arm A patients with ICD‐only and cardiac resynchronization therapy with defibrillator (CRT‐D). We additionally assessed benefit of novel ICD programming in Arms B and C versus Arm A by NYHA classification.
Results
In Arm A, the risk of inappropriate therapy was significantly higher in those with NYHA III versus NYHA I–II for both ICD (hazard ratio [HR] = 2.55, confidence interval [CI]: 1.51–4.30, P |
| doi_str_mv | 10.1111/pace.13216 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1954064594</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1977118324</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4236-d1c2688583561f5b2ad835855a4e4e50bd64c2549e98cfb0947de264330378013</originalsourceid><addsrcrecordid>eNp9kMtKw0AUhgdRbK1ufAAZcCNidK7JxF1pqy0oitR1mCQnmpKbM0mlOx_BZ_RJnFp14cKzmcOZj5-fD6FDSs6pm4tGJ3BOOaP-FupTKYinqAy3UZ9QEXiKq7CH9qxdEEJ8IuQu6rGQSMa430fpFLRpcabzojOALSzB5O3qDOeVbhpTNybXLeDZaIzbZzC6cV-6SnFVL6H4OjvoyeiyzKunS6zx7XA8m3-8vT_M5th2sW27dLWPdjJdWDj4fgfo8WoyH029m7vr2Wh44yXClfFSmjBfKam49GkmY6ZTtyoptQABksSpLxImRQihSrKYhCJIgfmCc8IDRSgfoJNNruv00oFtozK3CRSFrqDubERDJ8cXMhQOPf6DLurOVK6do4KAUsXZmjrdUImprTWQRc5Hqc0qoiRau4_W7qMv9w4--o7s4hLSX_RHtgPoBnjNC1j9ExXdD0eTTegnm1qMfw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977118324</pqid></control><display><type>article</type><title>Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Daimee, Usama A. ; Vermilye, Katherine ; Rosero, Spencer ; Schuger, Claudio D. ; Daubert, James P. ; Zareba, Wojciech ; McNitt, Scott ; Polonsky, Bronislava ; Moss, Arthur J. ; Kutyifa, Valentina</creator><creatorcontrib>Daimee, Usama A. ; Vermilye, Katherine ; Rosero, Spencer ; Schuger, Claudio D. ; Daubert, James P. ; Zareba, Wojciech ; McNitt, Scott ; Polonsky, Bronislava ; Moss, Arthur J. ; Kutyifa, Valentina</creatorcontrib><description><![CDATA[Background
The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter‐defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT‐RIT.
Methods
MADIT‐RIT randomized 1,500 patients to three ICD programming arms: conventional (Arm A), high‐rate cut‐off (Arm B: ≥200 beats/min), and delayed therapy (Arm C: 60‐second delay for ≥170 beats/min). We evaluated the association between New York Heart Association (NYHA) class III (n = 256) versus class I–II (n = 251) and inappropriate ICD therapy in Arm A patients with ICD‐only and cardiac resynchronization therapy with defibrillator (CRT‐D). We additionally assessed benefit of novel ICD programming in Arms B and C versus Arm A by NYHA classification.
Results
In Arm A, the risk of inappropriate therapy was significantly higher in those with NYHA III versus NYHA I–II for both ICD (hazard ratio [HR] = 2.55, confidence interval [CI]: 1.51–4.30, P < 0.001) and CRT‐D patients (HR = 3.73, CI: 1.14–12.23, P = 0.030). This was consistent for inappropriate ATP and inappropriate ICD therapy < 200 beats/min, but not for inappropriate shocks. Novel ICD programming significantly reduced inappropriate therapy in patients with both NYHA III (Arm B vs Arm A: HR = 0.08, P < 0.001; Arm C vs Arm A: HR = 0.17, P < 0.001) and NYHA I–II (Arm B vs Arm A: HR = 0.25, P < 0.001; Arm C vs Arm A: HR = 0.28, P < 0.001).
Conclusion
Patients with more severe HF are at increased risk for inappropriate ICD therapy, particularly ATP due to arrhythmias < 200 beats/min. Novel programming with high‐rate cut‐off or delayed detection reduces inappropriate ICD therapies in both mild and moderate HF.]]></description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/pace.13216</identifier><identifier>PMID: 29052236</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Cardiac Resynchronization Therapy ; Cardiovascular diseases ; Defibrillators ; Defibrillators, Implantable ; Female ; Heart diseases ; Heart failure ; Heart Failure - therapy ; HF severity ; Humans ; inappropriate ICD therapy ; Male ; Medical Overuse ; Middle Aged ; novel ICD programming ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Pacing and clinical electrophysiology, 2017-12, Vol.40 (12), p.1405-1411</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4236-d1c2688583561f5b2ad835855a4e4e50bd64c2549e98cfb0947de264330378013</citedby><cites>FETCH-LOGICAL-c4236-d1c2688583561f5b2ad835855a4e4e50bd64c2549e98cfb0947de264330378013</cites><orcidid>0000-0002-2839-5564</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpace.13216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpace.13216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29052236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daimee, Usama A.</creatorcontrib><creatorcontrib>Vermilye, Katherine</creatorcontrib><creatorcontrib>Rosero, Spencer</creatorcontrib><creatorcontrib>Schuger, Claudio D.</creatorcontrib><creatorcontrib>Daubert, James P.</creatorcontrib><creatorcontrib>Zareba, Wojciech</creatorcontrib><creatorcontrib>McNitt, Scott</creatorcontrib><creatorcontrib>Polonsky, Bronislava</creatorcontrib><creatorcontrib>Moss, Arthur J.</creatorcontrib><creatorcontrib>Kutyifa, Valentina</creatorcontrib><title>Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description><![CDATA[Background
The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter‐defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT‐RIT.
Methods
MADIT‐RIT randomized 1,500 patients to three ICD programming arms: conventional (Arm A), high‐rate cut‐off (Arm B: ≥200 beats/min), and delayed therapy (Arm C: 60‐second delay for ≥170 beats/min). We evaluated the association between New York Heart Association (NYHA) class III (n = 256) versus class I–II (n = 251) and inappropriate ICD therapy in Arm A patients with ICD‐only and cardiac resynchronization therapy with defibrillator (CRT‐D). We additionally assessed benefit of novel ICD programming in Arms B and C versus Arm A by NYHA classification.
Results
In Arm A, the risk of inappropriate therapy was significantly higher in those with NYHA III versus NYHA I–II for both ICD (hazard ratio [HR] = 2.55, confidence interval [CI]: 1.51–4.30, P < 0.001) and CRT‐D patients (HR = 3.73, CI: 1.14–12.23, P = 0.030). This was consistent for inappropriate ATP and inappropriate ICD therapy < 200 beats/min, but not for inappropriate shocks. Novel ICD programming significantly reduced inappropriate therapy in patients with both NYHA III (Arm B vs Arm A: HR = 0.08, P < 0.001; Arm C vs Arm A: HR = 0.17, P < 0.001) and NYHA I–II (Arm B vs Arm A: HR = 0.25, P < 0.001; Arm C vs Arm A: HR = 0.28, P < 0.001).
Conclusion
Patients with more severe HF are at increased risk for inappropriate ICD therapy, particularly ATP due to arrhythmias < 200 beats/min. Novel programming with high‐rate cut‐off or delayed detection reduces inappropriate ICD therapies in both mild and moderate HF.]]></description><subject>Cardiac Resynchronization Therapy</subject><subject>Cardiovascular diseases</subject><subject>Defibrillators</subject><subject>Defibrillators, Implantable</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart Failure - therapy</subject><subject>HF severity</subject><subject>Humans</subject><subject>inappropriate ICD therapy</subject><subject>Male</subject><subject>Medical Overuse</subject><subject>Middle Aged</subject><subject>novel ICD programming</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRbK1ufAAZcCNidK7JxF1pqy0oitR1mCQnmpKbM0mlOx_BZ_RJnFp14cKzmcOZj5-fD6FDSs6pm4tGJ3BOOaP-FupTKYinqAy3UZ9QEXiKq7CH9qxdEEJ8IuQu6rGQSMa430fpFLRpcabzojOALSzB5O3qDOeVbhpTNybXLeDZaIzbZzC6cV-6SnFVL6H4OjvoyeiyzKunS6zx7XA8m3-8vT_M5th2sW27dLWPdjJdWDj4fgfo8WoyH029m7vr2Wh44yXClfFSmjBfKam49GkmY6ZTtyoptQABksSpLxImRQihSrKYhCJIgfmCc8IDRSgfoJNNruv00oFtozK3CRSFrqDubERDJ8cXMhQOPf6DLurOVK6do4KAUsXZmjrdUImprTWQRc5Hqc0qoiRau4_W7qMv9w4--o7s4hLSX_RHtgPoBnjNC1j9ExXdD0eTTegnm1qMfw</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Daimee, Usama A.</creator><creator>Vermilye, Katherine</creator><creator>Rosero, Spencer</creator><creator>Schuger, Claudio D.</creator><creator>Daubert, James P.</creator><creator>Zareba, Wojciech</creator><creator>McNitt, Scott</creator><creator>Polonsky, Bronislava</creator><creator>Moss, Arthur J.</creator><creator>Kutyifa, Valentina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2839-5564</orcidid></search><sort><creationdate>201712</creationdate><title>Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy</title><author>Daimee, Usama A. ; Vermilye, Katherine ; Rosero, Spencer ; Schuger, Claudio D. ; Daubert, James P. ; Zareba, Wojciech ; McNitt, Scott ; Polonsky, Bronislava ; Moss, Arthur J. ; Kutyifa, Valentina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4236-d1c2688583561f5b2ad835855a4e4e50bd64c2549e98cfb0947de264330378013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cardiac Resynchronization Therapy</topic><topic>Cardiovascular diseases</topic><topic>Defibrillators</topic><topic>Defibrillators, Implantable</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart Failure - therapy</topic><topic>HF severity</topic><topic>Humans</topic><topic>inappropriate ICD therapy</topic><topic>Male</topic><topic>Medical Overuse</topic><topic>Middle Aged</topic><topic>novel ICD programming</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daimee, Usama A.</creatorcontrib><creatorcontrib>Vermilye, Katherine</creatorcontrib><creatorcontrib>Rosero, Spencer</creatorcontrib><creatorcontrib>Schuger, Claudio D.</creatorcontrib><creatorcontrib>Daubert, James P.</creatorcontrib><creatorcontrib>Zareba, Wojciech</creatorcontrib><creatorcontrib>McNitt, Scott</creatorcontrib><creatorcontrib>Polonsky, Bronislava</creatorcontrib><creatorcontrib>Moss, Arthur J.</creatorcontrib><creatorcontrib>Kutyifa, Valentina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daimee, Usama A.</au><au>Vermilye, Katherine</au><au>Rosero, Spencer</au><au>Schuger, Claudio D.</au><au>Daubert, James P.</au><au>Zareba, Wojciech</au><au>McNitt, Scott</au><au>Polonsky, Bronislava</au><au>Moss, Arthur J.</au><au>Kutyifa, Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>40</volume><issue>12</issue><spage>1405</spage><epage>1411</epage><pages>1405-1411</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract><![CDATA[Background
The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter‐defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT‐RIT.
Methods
MADIT‐RIT randomized 1,500 patients to three ICD programming arms: conventional (Arm A), high‐rate cut‐off (Arm B: ≥200 beats/min), and delayed therapy (Arm C: 60‐second delay for ≥170 beats/min). We evaluated the association between New York Heart Association (NYHA) class III (n = 256) versus class I–II (n = 251) and inappropriate ICD therapy in Arm A patients with ICD‐only and cardiac resynchronization therapy with defibrillator (CRT‐D). We additionally assessed benefit of novel ICD programming in Arms B and C versus Arm A by NYHA classification.
Results
In Arm A, the risk of inappropriate therapy was significantly higher in those with NYHA III versus NYHA I–II for both ICD (hazard ratio [HR] = 2.55, confidence interval [CI]: 1.51–4.30, P < 0.001) and CRT‐D patients (HR = 3.73, CI: 1.14–12.23, P = 0.030). This was consistent for inappropriate ATP and inappropriate ICD therapy < 200 beats/min, but not for inappropriate shocks. Novel ICD programming significantly reduced inappropriate therapy in patients with both NYHA III (Arm B vs Arm A: HR = 0.08, P < 0.001; Arm C vs Arm A: HR = 0.17, P < 0.001) and NYHA I–II (Arm B vs Arm A: HR = 0.25, P < 0.001; Arm C vs Arm A: HR = 0.28, P < 0.001).
Conclusion
Patients with more severe HF are at increased risk for inappropriate ICD therapy, particularly ATP due to arrhythmias < 200 beats/min. Novel programming with high‐rate cut‐off or delayed detection reduces inappropriate ICD therapies in both mild and moderate HF.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29052236</pmid><doi>10.1111/pace.13216</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2839-5564</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-8389 |
| ispartof | Pacing and clinical electrophysiology, 2017-12, Vol.40 (12), p.1405-1411 |
| issn | 0147-8389 1540-8159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1954064594 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cardiac Resynchronization Therapy Cardiovascular diseases Defibrillators Defibrillators, Implantable Female Heart diseases Heart failure Heart Failure - therapy HF severity Humans inappropriate ICD therapy Male Medical Overuse Middle Aged novel ICD programming Randomized Controlled Trials as Topic Retrospective Studies Severity of Illness Index |
| title | Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT‐RIT substudy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T02%3A11%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heart%20failure%20severity,%20inappropriate%20ICD%20therapy,%20and%20novel%20ICD%20programming:%20a%20MADIT%E2%80%90RIT%20substudy&rft.jtitle=Pacing%20and%20clinical%20electrophysiology&rft.au=Daimee,%20Usama%20A.&rft.date=2017-12&rft.volume=40&rft.issue=12&rft.spage=1405&rft.epage=1411&rft.pages=1405-1411&rft.issn=0147-8389&rft.eissn=1540-8159&rft_id=info:doi/10.1111/pace.13216&rft_dat=%3Cproquest_cross%3E1977118324%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1977118324&rft_id=info:pmid/29052236&rfr_iscdi=true |