Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery

Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery

Abstract OBJECTIVES This study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery. METHODS This is a prospective study that enrolled 80 patients who...

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Veröffentlicht in:Interactive cardiovascular and thoracic surgery 2018-01, Vol.26 (1), p.66-70
Hauptverfasser: Lu, Rongxin, Ma, Nan, Jiang, Zhaolei, Mei, Ju
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creator Lu, Rongxin
Ma, Nan
Jiang, Zhaolei
Mei, Ju
description Abstract OBJECTIVES This study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery. METHODS This is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. POAF was detected using a telemetry strip or 12-lead electrocardiogram until the time of discharge. RESULTS Patients undergoing mitral valve surgery with preoperative sinus rhythm (n = 80; average age 63.9 ± 7.9 years) were recruited to this study. POAF was documented in 31 (38.8%) patients. Preoperative plasma ET-1 levels were higher in patients with POAF compared to those without POAF (2.23 ± 0.67 vs 1.68 ± 0.59 pg/ml; P 
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METHODS This is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. POAF was detected using a telemetry strip or 12-lead electrocardiogram until the time of discharge. RESULTS Patients undergoing mitral valve surgery with preoperative sinus rhythm (n = 80; average age 63.9 ± 7.9 years) were recruited to this study. POAF was documented in 31 (38.8%) patients. Preoperative plasma ET-1 levels were higher in patients with POAF compared to those without POAF (2.23 ± 0.67 vs 1.68 ± 0.59 pg/ml; P &lt; 0.001). The plasma concentrations of ET-1 were positively correlated with LAD (Pearson’s r = 0.421; P &lt; 0.001). Multivariate logistic regression analysis revealed that LAD (odds ratio 1.170, 95% confidence interval 1.039–1.317; P = 0.009) and preoperative plasma ET-1 levels (upper versus lower 50th percentile: odds ratio 3.713, 95% confidence interval 1.085–12.701; P = 0.037) were predictors of POAF after mitral valve surgery. CONCLUSIONS Plasma levels of ET-1 were positively correlated with LAD in patients with mitral valve disease. An elevated preoperative plasma ET-1 level can be used as a predictor of POAF after mitral valve surgery.</description><identifier>ISSN: 1569-9293</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1093/icvts/ivx250</identifier><identifier>PMID: 29049685</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Interactive cardiovascular and thoracic surgery, 2018-01, Vol.26 (1), p.66-70</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-80d9aa5e38688d49423dfd57f259e2bf060fc755fe8736d96066ac99be84ae623</citedby><cites>FETCH-LOGICAL-c361t-80d9aa5e38688d49423dfd57f259e2bf060fc755fe8736d96066ac99be84ae623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1604,27924,27925</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/icvts/ivx250$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29049685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Rongxin</creatorcontrib><creatorcontrib>Ma, Nan</creatorcontrib><creatorcontrib>Jiang, Zhaolei</creatorcontrib><creatorcontrib>Mei, Ju</creatorcontrib><title>Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery</title><title>Interactive cardiovascular and thoracic surgery</title><addtitle>Interact Cardiovasc Thorac Surg</addtitle><description>Abstract OBJECTIVES This study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery. METHODS This is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. POAF was detected using a telemetry strip or 12-lead electrocardiogram until the time of discharge. RESULTS Patients undergoing mitral valve surgery with preoperative sinus rhythm (n = 80; average age 63.9 ± 7.9 years) were recruited to this study. POAF was documented in 31 (38.8%) patients. Preoperative plasma ET-1 levels were higher in patients with POAF compared to those without POAF (2.23 ± 0.67 vs 1.68 ± 0.59 pg/ml; P &lt; 0.001). The plasma concentrations of ET-1 were positively correlated with LAD (Pearson’s r = 0.421; P &lt; 0.001). Multivariate logistic regression analysis revealed that LAD (odds ratio 1.170, 95% confidence interval 1.039–1.317; P = 0.009) and preoperative plasma ET-1 levels (upper versus lower 50th percentile: odds ratio 3.713, 95% confidence interval 1.085–12.701; P = 0.037) were predictors of POAF after mitral valve surgery. CONCLUSIONS Plasma levels of ET-1 were positively correlated with LAD in patients with mitral valve disease. An elevated preoperative plasma ET-1 level can be used as a predictor of POAF after mitral valve surgery.</description><issn>1569-9293</issn><issn>1569-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kbtOxDAQRS0EguXRUSN3UBCwk9hrl2jFS1qJBurIscdglMTBdhb2O_hhsgQoaWauNGeuRnMROqbkghJZXDq9SvHSrT5yRrbQjDIuM5kLtv2nZbGH9mN8JYRKUpBdtJdLUkou2Ax9XnfGpxdoXJdR7CJWMXrtVAKD3116wcY1KqnkfIe9xSOJG7AJqxTc0GLVGaxVh2sYJXadgR7G0iXcBzBOJx82axtaNdi6OrimmdyUTRBw61IYJyvVrADHITxDWB-iHauaCEc__QA93Vw_Lu6y5cPt_eJqmemC05QJYqRSDArBhTClLPPCWMPmNmcS8toSTqyeM2ZBzAtuJCecKy1lDaJUwPPiAJ1Nvn3wbwPEVLUuahgP7MAPsaKSlYSXVNARPZ9QHXyMAWzVB9eqsK4oqTYxVN8xVFMMI37y4zzULZg_-PfvI3A6AX7o_7f6AsI1lbU</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Lu, Rongxin</creator><creator>Ma, Nan</creator><creator>Jiang, Zhaolei</creator><creator>Mei, Ju</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery</title><author>Lu, Rongxin ; Ma, Nan ; Jiang, Zhaolei ; Mei, Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-80d9aa5e38688d49423dfd57f259e2bf060fc755fe8736d96066ac99be84ae623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Rongxin</creatorcontrib><creatorcontrib>Ma, Nan</creatorcontrib><creatorcontrib>Jiang, Zhaolei</creatorcontrib><creatorcontrib>Mei, Ju</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Interactive cardiovascular and thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lu, Rongxin</au><au>Ma, Nan</au><au>Jiang, Zhaolei</au><au>Mei, Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery</atitle><jtitle>Interactive cardiovascular and thoracic surgery</jtitle><addtitle>Interact Cardiovasc Thorac Surg</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>26</volume><issue>1</issue><spage>66</spage><epage>70</epage><pages>66-70</pages><issn>1569-9293</issn><eissn>1569-9285</eissn><abstract>Abstract OBJECTIVES This study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery. METHODS This is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. POAF was detected using a telemetry strip or 12-lead electrocardiogram until the time of discharge. RESULTS Patients undergoing mitral valve surgery with preoperative sinus rhythm (n = 80; average age 63.9 ± 7.9 years) were recruited to this study. POAF was documented in 31 (38.8%) patients. Preoperative plasma ET-1 levels were higher in patients with POAF compared to those without POAF (2.23 ± 0.67 vs 1.68 ± 0.59 pg/ml; P &lt; 0.001). The plasma concentrations of ET-1 were positively correlated with LAD (Pearson’s r = 0.421; P &lt; 0.001). Multivariate logistic regression analysis revealed that LAD (odds ratio 1.170, 95% confidence interval 1.039–1.317; P = 0.009) and preoperative plasma ET-1 levels (upper versus lower 50th percentile: odds ratio 3.713, 95% confidence interval 1.085–12.701; P = 0.037) were predictors of POAF after mitral valve surgery. CONCLUSIONS Plasma levels of ET-1 were positively correlated with LAD in patients with mitral valve disease. An elevated preoperative plasma ET-1 level can be used as a predictor of POAF after mitral valve surgery.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29049685</pmid><doi>10.1093/icvts/ivx250</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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title Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery
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